日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Discontinuation of First-Line Disease-Modifying Therapy in Patients With Stable Multiple Sclerosis: The DOT-MS Randomized Clinical Trial

稳定期多发性硬化症患者停止一线疾病修饰疗法：DOT-MS随机临床试验

期刊:Jama Neurology
影响因子:21.3
doi:10.1001/jamaneurol.2024.4164
Coerver, Eline M E; Fung, Wing Hee; de Beukelaar, Janet; Bouvy, Willem H; Canta, Leo R; Gerlach, Oliver H H; Hoitsma, Elske; Hoogervorst, Erwin L J; de Jong, Brigit A; Kalkers, Nynke F; van Kempen, Zoé L E; Lövenich, Harry; van Munster, Caspar E P; van Oosten, Bob W; Smolders, Joost; Vennegoor, Anke; Zeinstra, Esther M P E; Barrantes-Cepas, Mar; Kooij, Gijs; Schoonheim, Menno M; Lissenberg-Witte, Birgit I; Teunissen, Charlotte E; Moraal, Bastiaan; Barkhof, Frederik; Uitdehaag, Bernard M J; Mostert, Jop; Killestein, Joep; Strijbis, Eva M M
神经科学
多发性硬化症
发表日期：2025
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Low natalizumab trough concentrations are associated with reduced seroconversion of the John Cunningham virus in natalizumab-treated patients with multiple sclerosis

在接受纳他珠单抗治疗的多发性硬化症患者中，纳他珠单抗谷浓度低与约翰·坎宁安病毒血清转化率降低相关。

期刊:Journal of Neurology Neurosurgery and Psychiatry
影响因子:7.5
doi:10.1136/jnnp-2024-335761
Gelissen, Liza M Y; Toorop, Alyssa A; Schipper, Pien M; Hoitsma, Elske; Zeinstra, Esther M P E; van Rooij, Luuk C; van Munster, Caspar E P; Vennegoor, Anke; Mostert, Jop; Wokke, Beatrijs; Kalkers, Nynke F; Hoogervorst, Erwin L J; van Eijk, Jeroen; Roosendaal, Christiaan M; Kragt, Jolijn J; Eurelings, Marijke; van Genugten, Jessie; Nielsen, Jessica; Sinnige, L G F; Kloosterziel, Mark E; Arnoldus, Edo P J; Bouvy, Willem H; Strijbis, Eva M; Oosten, Bob van; De Jong, Brigit A; Uitdehaag, Bernard M J; Lissenberg-Witte, Birgit I; Loeff, Floris C; Rispens, Theo; Killestein, Joep; van Kempen, Zoé L E
微生物学
神经科学
多发性硬化症
发表日期：2025
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Reliability of serum neurofilament light and glial fibrillary acidic protein for detecting disease activity upon discontinuation of first-line disease-modifying therapy in stable multiple sclerosis (DOT-MS)

血清神经丝轻链和胶质纤维酸性蛋白在稳定期多发性硬化症患者停用一线疾病修饰疗法后检测疾病活动的可靠性（DOT-MS）

期刊:Journal of Neurology
影响因子:4.6
doi:10.1007/s00415-025-13231-9
Fung, W H; Wessels, M H J; Coerver, E M E; de Beukelaar, J; Bouvy, W H; Canta, L R; Gerlach, O H H; Hoitsma, E; Hoogervorst, E L J; de Jong, B A; Kalkers, N F; van Kempen, Z L E; Lövenich, H; van Munster, C E P; van Oosten, B W; Smolders, J; Vennegoor, A; Zeinstra, E M P E; Barrantes-Cepas, M; Kooij, G; Schoonheim, M M; Lissenberg-Witte, B I; Moraal, B; Barkhof, F; Uitdehaag, B M J; Mostert, J; Teunissen, C E; Killestein, J; Strijbis, E M M
神经科学
多发性硬化症
发表日期：2025
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APE1 active site residue Asn174 stabilizes the AP site and is essential for catalysis

APE1活性位点残基Asn174稳定AP位点，对催化至关重要。

期刊:Journal of Biological Chemistry
影响因子:3.9
doi:10.1016/j.jbc.2025.110655
DeHart, Kaitlin M; Hoitsma, Nicole M; Thompson, Spencer H; Borin, Veniamin A; Agarwal, Pratul K; Freudenthal, Bret D
发表日期：2025
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APE1 active site residue Asn174 stabilizes the AP-site and is essential for catalysis

APE1活性位点残基Asn174稳定AP位点，对催化至关重要。

期刊:
影响因子:
doi:10.1101/2025.01.14.633034
DeHart, Kaitlin M; Hoitsma, Nicole M; Thompson, Spencer H; Borin, Veniamin A; Agarwal, Pratul K; Freudenthal, Bret D
发表日期：2025
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Characterization of Medusavirus encoded histones reveals nucleosome-like structures and a unique linker histone

美杜莎病毒编码组蛋白的表征揭示了核小体样结构和独特的连接组蛋白

期刊:Nature Communications
影响因子:14.7
doi:10.1038/s41467-024-53364-5
Chelsea M Toner #, Nicole M Hoitsma #, Sashi Weerawarana, Karolin Luger
免疫
微生物学
发表日期：2024
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Serum neurofilament light and glial fibrillary acidic protein levels are not associated with wearing-off symptoms in natalizumab-treated multiple sclerosis patients

血清神经丝轻链和胶质纤维酸性蛋白水平与接受那他珠单抗治疗的多发性硬化症患者的疗效减退症状无关

期刊:Multiple Sclerosis Journal
影响因子:5
doi:10.1177/13524585241293940
Toorop, Alyssa A; Wessels, Mark Hj; Boonkamp, Lynn; Gelissen, Liza My; Hoitsma, E; Zeinstra, Esther Mpe; van Rooij, Luuk C; van Munster, Caspar Ep; Vennegoor, Anke; Mostert, Jop P; Wokke, Beatrijs Ha; Kalkers, Nynke F; Hoogervorst, Erwin Lj; van Eijk, Jeroen Jj; Roosendaal, Christiaan M; Kragt, Jolijn J; Eurelings, Marijke; van Genugten, Jessie; Nielsen, Jessica; Sinnige, Lgf; Kloosterziel, Mark E; Arnoldus, Edo Pj; van Dijk, Gert W; Bouvy, Willem H; Strijbis, Eva Mm; van Oosten, Bob W; de Jong, Brigit A; Uitdehaag, Bernard Mj; Rispens, Theo; Killestein, Joep; van Kempen, Zoé LE; Teunissen, Charlotte E
神经科学
多发性硬化症
发表日期：2024
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The feasibility and usability of a personal health record for patients with multiple sclerosis: a 2-year evaluation study

个人健康记录在多发性硬化症患者中的可行性和可用性：一项为期2年的评估研究

期刊:Frontiers in Human Neuroscience
影响因子:2.7
doi:10.3389/fnhum.2024.1379780
van den Berg, Liselot N; Aardoom, Jiska J; Kiveron, Léone E; Botterweg, Robert D; van den Akker-van Marle, M Elske; Chavannes, Niels H; Hoitsma, Elske
神经科学
多发性硬化症
发表日期：2024
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Mechanistic insight into AP-endonuclease 1 cleavage of abasic sites at stalled replication fork mimics.

对 AP 核酸内切酶 1 切割停滞复制叉模拟物中无碱基位点的机制的深入了解

期刊:Nucleic Acids Research
影响因子:13.1
doi:10.1093/nar/gkad481
Hoitsma Nicole M, Norris Jessica, Khoang Thu H, Kaushik Vikas, Chadda Rahul, Antony Edwin, Hedglin Mark, Freudenthal Bret D
其它
发表日期：2023
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Structural basis for APE1 processing DNA damage in the nucleosome

APE1在核小体中处理DNA损伤的结构基础

期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-022-33057-7
Weaver, Tyler M; Hoitsma, Nicole M; Spencer, Jonah J; Gakhar, Lokesh; Schnicker, Nicholas J; Freudenthal, Bret D
毒理研究
发表日期：2022
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