日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Accurate predictions of disordered protein ensembles with STARLING

利用STARLING对无序蛋白质集合进行精确预测

Novak, Borna; Lotthammer, Jeffrey M; Emenecker, Ryan J; Holehouse, Alex S

Sequence and chemical specificity define the functional landscape of intrinsically disordered regions

序列和化学特异性决定了固有无序区域的功能特征

Langstein-Skora, Iris; Schmid, Andrea; Huth, Frauke; Shabani, Drin; Spechtenhauser, Lorenz; Likhodeeva, Mariia; Kunert, Franziska; Metzner, Felix J; Emenecker, Ryan J; Richardson, Mary O; Aftab, Wasim; Götz, Maximilian J; Payer, Sarah K; Pietrantoni, Niccoló; Valka, Valentina; Ravichandran, Sakthi K; Bartke, Till; Hopfner, Karl-Peter; Gerland, Ulrich; Korber, Philipp; Holehouse, Alex S

The filamentous ultrastructure of the PopZ condensate is required for its cellular function

PopZ凝聚体的丝状超微结构对其细胞功能至关重要。

Scholl, Daniel; Boyd, Tumara; Latham, Andrew P; Salazar, Alexandra; Khan, Asma M A M; Boeynaems, Steven; Holehouse, Alex S; Lander, Gabriel C; Sali, Andrej; Park, Donghyun; Deniz, Ashok A; Lasker, Keren

Scaling laws for function diversity and specialization across socioeconomic and biological complex systems

社会经济和生物复杂系统中功能多样性和专业化的尺度规律

Yang, Vicky Chuqiao; Holehouse, James; Youn, Hyejin; Arroyo, José Ignacio; Redner, Sidney; West, Geoffrey B; Kempes, Christopher P

A Dataset Showing a Century of Evolution in the Complexity of the United States Legal Code

一份展现美国法律复杂性百年演变的数据集

Jeong, Dawoon; Holehouse, James; Yoon, Jisung; Kempes, Christopher P; West, Geoffrey B; Youn, Hyejin

Sequence-based prediction of intermolecular interactions driven by disordered regions

基于序列的无序区域驱动的分子间相互作用预测

Ginell, Garrett M; Emenecker, Ryan J; Lotthammer, Jeffrey M; Keeley, Alex T; Plassmeyer, Stephen P; Razo, Nicholas; Usher, Emery T; Pelham, Jaqueline F; Holehouse, Alex S

Molecular determinants of condensate composition

凝聚态物质组成的分子决定因素

Holehouse, Alex S; Alberti, Simon

Multiomic Characterization of Pre- and Post-Neoadjuvant Chemotherapy-Treated Ovarian Cancer Reveals Mediators of Tumorigenesis and Chemotherapy Response

新辅助化疗前后卵巢癌的多组学特征分析揭示了肿瘤发生和化疗反应的介质

Valentine, Mark C; Mullen, Mary M; Kotnik, Emilee N; Powell, Matthew A; Thaker, Premal H; McCourt, Carolyn K; Kuroki, Lindsay M; Hagemann, Andrea R; Arend, Rebecca C; Holehouse, Alex S; Mitra, Robi; Mutch, David G; Fuh, Katherine C

Widespread variation in molecular interactions and regulatory properties among transcription factor isoforms.

转录因子亚型之间分子相互作用和调控特性存在广泛差异

Lambourne Luke, Mattioli Kaia, Santoso Clarissa, Sheynkman Gloria, Inukai Sachi, Kaundal Babita, Berenson Anna, Spirohn-Fitzgerald Kerstin, Bhattacharjee Anukana, Rothman Elisabeth, Shrestha Shaleen, Laval Florent, Carroll Brent S, Plassmeyer Stephen P, Emenecker Ryan J, Yang Zhipeng, Bisht Deepa, Sewell Jared A, Li Guangyuan, Prasad Anisa, Phanor Sabrina, Lane Ryan, Moyer Devlin C, Hunt Toby, Balcha Dawit, Gebbia Marinella, Twizere Jean-Claude, Hao Tong, Holehouse Alex S, Frankish Adam, Riback Josh A, Salomonis Nathan, Calderwood Michael A, Hill David E, Sahni Nidhi, Vidal Marc, Bulyk Martha L, Fuxman Bass Juan I

The dimerization domain of SARS-CoV-2 nucleocapsid protein is partially disordered and forms a dynamic high-affinity dimer

SARS-CoV-2核衣壳蛋白的二聚化结构域部分无序,并形成动态的高亲和力二聚体。

Cubuk, Jasmine; Incicco, J Jeremías; Hall, Kathleen B; Holehouse, Alex S; Stuchell-Brereton, Melissa D; Soranno, Andrea