日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A Randomized, Double-Blinded, Placebo-Controlled QTc Study to Evaluate BIA 28-6156 Effect on Cardiac Repolarization in Healthy Volunteers

一项随机、双盲、安慰剂对照的QTc研究,旨在评估BIA 28-6156对健康志愿者心脏复极化的影响

Peixoto, Isa; Hilt, Dana; Carvalho, Teresa; Reis, João; Gama, Helena; Holenz, Joerg

Opicapone as adjunct to levodopa in treated Parkinson's disease without motor complications: A randomized clinical trial

奥匹卡朋作为左旋多巴辅助药物治疗无运动并发症的帕金森病:一项随机临床试验

Ferreira, Joaquim J; Rascol, Olivier; Stocchi, Fabrizio; Antonini, Angelo; Moreira, Joana; Castilla-Fernández, Guillermo; Rocha, José-Francisco; Holenz, Joerg; Poewe, Werner

Early start of opicapone in Parkinson's disease: evidence from a pooled analysis of phase 3 trials for sustained benefit in patients with recent onset of motor fluctuations

帕金森病早期应用奥匹卡朋:来自3期临床试验汇总分析的证据显示,对于近期出现运动波动症状的患者,该疗法可带来持续获益

Ferreira, Joaquim J; Stocchi, Fabrizio; Antonini, Angelo; Rascol, Olivier; Ebersbach, Georg; Kulisevsky, Jaime; Fonseca, Miguel M; Ramos, Daniel; Rocha, José Francisco; Brigas, Helena C; Holenz, Joerg; Poewe, Werner

The small molecule CLP257 does not modify activity of the K+-Cl- co-transporter KCC2 but does potentiate GABAA receptor activity

小分子 CLP257 不会改变 K+-Cl- 共转运体 KCC2 的活性,但会增强 GABAA 受体活性

Ross A Cardarelli, Karen Jones, Lucie I Pisella, Heike J Wobst, Lisa J McWilliams, Paul M Sharpe, Matthew P Burnham, David J Baker, Ilona Chudotvorova, Justine Guyot, Liliya Silayeva, Danielle H Morrow, Niek Dekker, Stephen Zicha, Paul A Davies, Jörg Holenz, Mark E Duggan, John Dunlop, Robert J Math

Chronic 5-HT6 receptor modulation by E-6837 induces hypophagia and sustained weight loss in diet-induced obese rats

E-6837对5-HT6受体的慢性调节可导致饮食诱导肥胖大鼠食欲减退和持续性体重下降。

Fisas, Angels; Codony, Xavier; Romero, Gonzalo; Dordal, Alberto; Giraldo, Jesus; Mercé, Ramon; Holenz, Jörg; Vrang, N; Sørensen, R V; Heal, David; Buschmann, Helmut; Pauwels, Petrus Johan

Naphthylisoquinoline alkaloids against malaria: evaluation of the curative potentials of dioncophylline C and dioncopeltine A against Plasmodium berghei in vivo

萘基异喹啉生物碱抗疟疾:体内评价二氢萘酚碱C和二氢萘酚碱A对伯氏疟原虫的治疗潜力

François, G; Timperman, G; Eling, W; Assi, L A; Holenz, J; Bringmann, G