Epitope and Fc-Mediated Cross-linking, but Not High Affinity, Are Critical for Antitumor Activity of CD137 Agonist Antibody with Reduced Liver Toxicity
表位和 Fc 介导的交联(而非高亲和力)对于降低肝毒性的 CD137 激动剂抗体的抗肿瘤活性至关重要
期刊:Molecular Cancer Therapeutics
影响因子:5.3
doi:10.1158/1535-7163.MCT-19-0608
Sun K Ho, Zhenghai Xu, Archana Thakur, Melvin Fox, Siu Sze Tan, Enrico DiGiammarino, Li Zhou, Mien Sho, Belinda Cairns, Vivian Zhao, Mengli Xiong, Josue Samayoa, Charles M Forsyth, David B Powers, Debra T Chao, Diane Hollenbaugh, Hamsell M Alvarez, Yoshiko Akamatsu