日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Tunable Biased Signaling of the Angiotensin II Type 1 Receptor for Inotropy via C-Terminal Peptide Engineering and Allosteric Site Targeting

通过C端肽工程和变构位点靶向调控血管紧张素II 1型受体的正性肌力信号传导

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.5c01259
Hadjadj, Margot; Hassanzadeh, Malihe; Martel, Justin; Roy, Marie-Frédérique; Giguère, Hugo; Murza, Alexandre; Holleran, Brian J; Namkung, Yoon; Froehlich, Ulrike; Leduc, Richard; Auger-Messier, Mannix; Laporte, Stéphane A; Boudreault, Pierre-Luc
信号转导
发表日期：2026
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Trifluoromethylthio and Trifluoromethyl Functionalization of Endomorphin-1 Enhances its Hydrophobicity and Plasma Stability while Preserving its Affinity for the μ-Opioid Receptor

内啡肽-1的三氟甲基硫代和三氟甲基功能化增强了其疏水性和血浆稳定性，同时保持了其对μ-阿片受体的亲和力。

期刊:Journal of Organic Chemistry
影响因子:3.6
doi:10.1021/acs.joc.6c00321
Gregorc, Jure; De Neve, Jolien; Guitot, Karine; Holleran, Brian J; Lensen, Nathalie; Gendron, Louis; Brigaud, Thierry; Iskra, Jernej; Ballet, Steven; Chaume, Grégory
信号转导
发表日期：2026
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Class A and B GPCRs trigger rapid Gα(s) translocation to late and slow recycling endosomes

A类和B类GPCR触发Gα(s)快速易位至晚期和慢速循环内体。

期刊:Communications Biology
影响因子:5.1
doi:10.1038/s42003-025-09117-1
Laniel, Andréanne; Holleran, Brian; Labonté, Émy; Grondin, Sarah-Janne; Boudreault, Pierre-Luc; Lavoie, Christine
GPCR/Calcium/cAMP
发表日期：2025
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Design, Synthesis, and In Vitro Characterization of Proteolytically-Stable Opioid-Neurotensin Hybrid Peptidomimetics

蛋白水解稳定的阿片-神经降压素杂合肽模拟物的设计、合成和体外表征

期刊:ACS Pharmacology and Translational Science
影响因子:3.7
doi:10.1021/acsptsci.4c00236
De Neve, Jolien; Breault, Émile; Previti, Santo; Vangeloven, Esaü; Loranger, Bobbi; Chartier, Magali; Brouillette, Rebecca; Lanoie, Annik; Holleran, Brian J; Longpré, Jean-Michel; Gendron, Louis; Tourwé, Dirk; Sarret, Philippe; Ballet, Steven
发表日期：2024
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Monitoring TRPC7 Conformational Changes by BRET Following GPCR Activation

利用BRET监测GPCR激活后TRPC7构象变化

期刊:International Journal of Molecular Sciences
影响因子:4.9
doi:10.3390/ijms23052502
Pétigny, Cécile; Dumont, Audrey-Ann; Giguère, Hugo; Collette, Audrey; Holleran, Brian J; Iftinca, Mircea; Altier, Christophe; Besserer-Offroy, Élie; Auger-Messier, Mannix; Leduc, Richard
GPCR/Calcium/cAMP
RET
发表日期：2022
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Evaluation of the pharmacokinetic drug-drug interaction potential of iohexol, a renal filtration marker

评估肾脏滤过标志物碘海醇的药代动力学药物相互作用潜力

期刊:Cancer Chemotherapy and Pharmacology
影响因子:2.7
doi:10.1007/s00280-020-04145-6
Anand Joshi, Jianxia Guo, Julianne L Holleran, Brian Kiesel, Sarah Taylor, Susan Christner, Robert A Parise, Brian M Miller, S Percy Ivy, Edward Chu, Raman Venkataramanan, Jan H Beumer
发表日期：2020
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GRK2 knockdown in mice exacerbates kidney injury and alters renal mechanisms of blood pressure regulation

小鼠GRK2基因敲除会加剧肾损伤并改变肾脏血压调节机制。

期刊:Scientific Reports
影响因子:3.9
doi:10.1038/s41598-018-29876-8
Tutunea-Fatan, Elena; Abd-Elrahman, Khaled S; Thibodeau, Jean-Francois; Holterman, Chet E; Holleran, Brian J; Leduc, Richard; Kennedy, Christopher R J; Gros, Robert; Ferguson, Stephen S G
毒理研究
肾损伤
发表日期：2018
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Gα(s) protein binds ubiquitin to regulate epidermal growth factor receptor endosomal sorting

Gα(s)蛋白结合泛素以调节表皮生长因子受体内体分选

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.1708215114
Li, Xuezhi; Létourneau, Danny; Holleran, Brian; Leduc, Richard; Lavigne, Pierre; Lavoie, Christine
信号转导
发表日期：2017
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Identification of Distinct Conformations of the Angiotensin-II Type 1 Receptor Associated with the Gq/11 Protein Pathway and the β-Arrestin Pathway Using Molecular Dynamics Simulations.

利用分子动力学模拟鉴定与 Gq/11 蛋白通路和 β-阻遏蛋白通路相关的血管紧张素 II 1 型受体的不同构象

期刊:Journal of Biological Chemistry
影响因子:3.9
doi:10.1074/jbc.M114.627356
Cabana Jérôme, Holleran Brian, Leduc Richard, Escher Emanuel, Guillemette Gaétan, Lavigne Pierre
信号转导
血管生成
发表日期：2015
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The second transmembrane domain of the human type 1 angiotensin II receptor participates in the formation of the ligand binding pocket and undergoes integral pivoting movement during the process of receptor activation

人I型血管紧张素II受体的第二个跨膜结构域参与配体结合口袋的形成，并在受体激活过程中发生整体枢轴运动。

期刊:Journal of Biological Chemistry
影响因子:3.9
doi:10.1074/jbc.M808113200
Domazet, Ivana; Holleran, Brian J; Martin, Stéphane S; Lavigne, Pierre; Leduc, Richard; Escher, Emanuel; Guillemette, Gaétan
信号转导
发表日期：2009
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