日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

HDAC2 targeting stabilizes the CoREST complex in renal tubular cells and protects against renal ischemia/reperfusion injury

靶向 HDAC2 可稳定肾小管细胞中的 CoREST 复合物,并保护肾脏免受缺血/再灌注损伤。

Aufhauser, David D Jr; Hernandez, Paul; Concors, Seth J; O'Brien, Ciaran; Wang, Zhonglin; Murken, Douglas R; Samanta, Arabinda; Beier, Ulf H; Krumeich, Lauren; Bhatti, Tricia R; Wang, Yanfeng; Ge, Guanghui; Wang, Liqing; Cheraghlou, Shayan; Wagner, Florence F; Holson, Edward B; Kalin, Jay H; Cole, Philip A; Hancock, Wayne W; Levine, Matthew H

Isoform-selective inhibitor of histone deacetylase 3 (HDAC3) limits pancreatic islet infiltration and protects female nonobese diabetic mice from diabetes.

组蛋白去乙酰化酶 3 (HDAC3) 的亚型选择性抑制剂可限制胰岛浸润,并保护雌性非肥胖糖尿病小鼠免受糖尿病的侵害

Dirice Ercument, Ng Raymond W S, Martinez Rachael, Hu Jiang, Wagner Florence F, Holson Edward B, Wagner Bridget K, Kulkarni Rohit N

Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate

运动通过酮体β-羟基丁酸的作用促进脑源性神经营养因子(BDNF)的表达。

Sleiman, Sama F; Henry, Jeffrey; Al-Haddad, Rami; El Hayek, Lauretta; Abou Haidar, Edwina; Stringer, Thomas; Ulja, Devyani; Karuppagounder, Saravanan S; Holson, Edward B; Ratan, Rajiv R; Ninan, Ipe; Chao, Moses V

Hydroxamate-based histone deacetylase inhibitors can protect neurons from oxidative stress via a histone deacetylase-independent catalase-like mechanism

基于羟肟酸的组蛋白去乙酰化酶抑制剂可通过一种不依赖于组蛋白去乙酰化酶的类过氧化氢酶机制保护神经元免受氧化应激损伤。

Olson, David E; Sleiman, Sama F; Bourassa, Megan W; Wagner, Florence F; Gale, Jennifer P; Zhang, Yan-Ling; Ratan, Rajiv R; Holson, Edward B

An unbiased approach to identify endogenous substrates of "histone" deacetylase 8

一种鉴定“组蛋白”去乙酰化酶 8 内源性底物的无偏方法

Olson, David E; Udeshi, Namrata D; Wolfson, Noah A; Pitcairn, Carol Ann; Sullivan, Eric D; Jaffe, Jacob D; Svinkina, Tanya; Natoli, Ted; Lu, Xiaodong; Paulk, Joshiawa; McCarren, Patrick; Wagner, Florence F; Barker, Doug; Howe, Eleanor; Lazzaro, Fanny; Gale, Jennifer P; Zhang, Yan-Ling; Subramanian, Aravind; Fierke, Carol A; Carr, Steven A; Holson, Edward B

Selective HDAC inhibition for the disruption of latent HIV-1 infection.

选择性 HDAC 抑制剂用于破坏潜伏性 HIV-1 感染

Barton Kirston M, Archin Nancie M, Keedy Kara S, Espeseth Amy S, Zhang Yan-ling, Gale Jennifer, Wagner Florence F, Holson Edward B, Margolis David M

Small molecule inhibitors of zinc-dependent histone deacetylases

锌依赖性组蛋白去乙酰化酶的小分子抑制剂

Wagner, Florence F; Weїwer, Michel; Lewis, Michael C; Holson, Edward B

FDG-PET imaging reveals local brain glucose utilization is altered by class I histone deacetylase inhibitors

FDG-PET成像显示,I类组蛋白去乙酰化酶抑制剂会改变局部脑葡萄糖的利用率。

Schroeder, Frederick A; Chonde, Daniel B; Riley, Misha M; Moseley, Christian K; Granda, Michael L; Wilson, Colin M; Wagner, Florence F; Zhang, Yan-Ling; Gale, Jennifer; Holson, Edward B; Haggarty, Stephen J; Hooker, Jacob M

Synthesis and profiling of a diverse collection of azetidine-based scaffolds for the development of CNS-focused lead-like libraries

合成和分析多种基于氮杂环丁烷的骨架化合物,用于开发针对中枢神经系统的先导化合物库

Lowe, Jason T; Lee, Maurice D 4th; Akella, Lakshmi B; Davoine, Emeline; Donckele, Etienne J; Durak, Landon; Duvall, Jeremy R; Gerard, Baudouin; Holson, Edward B; Joliton, Adrien; Kesavan, Sarathy; Lemercier, Berenice C; Liu, Haibo; Marié, Jean-Charles; Mulrooney, Carol A; Muncipinto, Giovanni; Welzel-O'Shea, Morgan; Panko, Laura M; Rowley, Ann; Suh, Byung-Chul; Thomas, Meryl; Wagner, Florence F; Wei, Jingqiang; Foley, Michael A; Marcaurelle, Lisa A

Inhibition of histone deacetylase 3 protects beta cells from cytokine-induced apoptosis

抑制组蛋白去乙酰化酶3可保护β细胞免受细胞因子诱导的细胞凋亡

Chou, Danny Hung-Chieh; Holson, Edward B; Wagner, Florence F; Tang, Alicia J; Maglathlin, Rebecca L; Lewis, Timothy A; Schreiber, Stuart L; Wagner, Bridget K