日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Accelerating Leigh syndrome drug discovery through deep learning screening in brain organoids

利用脑类器官深度学习筛选加速莱氏综合征药物研发

Menacho, Carmen; Okawa, Satoshi; Álvarez-Merz, Iris; Wittich, Annika; Muñoz-Oreja, Mikel; Lisowski, Pawel; Martín, Mario López; Pentimalli, Tancredi Massimo; Zakin, Shiri; Thevandavakkam, Mathuravani; Jerred, Caleb; Lickfett, Selene; Petersilie, Laura; Rybak-Wolf, Agnieszka; Seibt, Annette; Herebian, Diran; Inak, Gizem; Brodesser, Susanne; Zaliani, Andrea; Mlody, Barbara; Donnelly, Justin; Woleben, Kasey; Soriano, Francesc Xavier; Fernandez-Checa, Jose C; Ventura, Natascia; Cambridge, Sidney; Mayatepek, Ertan; Spinazzola, Antonella; Schuelke, Markus; Rajewsky, Nikolaus; Rossi, Andrea; Peralvarez-Marin, Alex; Distelmaier, Felix; Perlstein, Ethan; Holt, Ian J; Puighermanal, Emma; Pless, Ole; Rose, Christine R; Del Sol, Antonio; Prigione, Alessandro

Mitochondrial DNA replication is regulated by endoplasmic reticulum-mitochondrial contact sites, the mitochondrial calcium uniporter, and manganese

线粒体DNA复制受内质网-线粒体接触位点、线粒体钙单向转运蛋白和锰的调控。

Lopez de Arbina, Amaia; Zamudio-Ochoa, Angelica; Muñoz-Oreja, Mikel; Perez-Rodriguez, Diego; Mosqueira-Martín, Laura; Lasalandra, Rebecca; Villar-Fernandez, Marina; Fernandez-Pelayo, Uxoa; Rodriguez-Gomez, Laura; Lee, Seungtae; Gil-Bea, Francisco; Osinalde, Nerea; Vallejo-Illaramendi, Ainara; Temiakov, Dmitry; Spinazzola, Antonella; Holt, Ian J

Timekeepers of the gut: host circadian rhythms and microbial modulators

肠道的计时员:宿主昼夜节律和微生物调节剂

Yuan, Xinjie; Cai, Bowei; Hamamura, Yuki; Schnittger, Arp; Yang, Chao; Schreiber, Alison M; Hallquist, Michael N; Lopez de Arbina, Amaia; Zamudio-Ochoa, Angelica; Muñoz-Oreja, Mikel; Perez-Rodriguez, Diego; Mosqueira-Martín, Laura; Lasalandra, Rebecca; Villar-Fernandez, Marina; Fernandez-Pelayo, Uxoa; Rodriguez-Gomez, Laura; Lee, Seungtae; Gil-Bea, Francisco; Osinalde, Nerea; Vallejo-Illaramendi, Ainara; Temiakov, Dmitry; Spinazzola, Antonella; Holt, Ian J; Liu, Qiang; Tu, Shaohua; Zhao, Chunmei; Ji, Nan; Luo, Fang; Cao, Jing; Ding, Deguang; Ming, Xiuhua; Liu, Chuang; Xu, Yangyang; Zhou, Huan; Ran, Yili; Jiang, Yi; Li, Ruoqing; Ma, Xianda; Yu, Qiyi; Kuang, Zheng

Metabolic Malfunction Mars Muscle Mitochondria

代谢功能障碍影响肌肉线粒体

Primiano, Guido; Holt, Ian

Defects of Nutrient Signaling and Autophagy in Neurodegeneration

神经退行性疾病中营养信号传导和自噬的缺陷

Ondaro, Jon; Hernandez-Eguiazu, Haizea; Garciandia-Arcelus, Maddi; Loera-Valencia, Raúl; Rodriguez-Gómez, Laura; Jiménez-Zúñiga, Andrés; Goikolea, Julen; Rodriguez-Rodriguez, Patricia; Ruiz-Martinez, Javier; Moreno, Fermín; Lopez de Munain, Adolfo; Holt, Ian James; Gil-Bea, Francisco Javier; Gereñu, Gorka

2 deoxy-D-glucose augments the mitochondrial respiratory chain in heart

2-脱氧-D-葡萄糖增强心脏线粒体呼吸链

Aiestaran-Zelaia, Irati; Sánchez-Guisado, María Jesús; Villar-Fernandez, Marina; Azkargorta, Mikel; Fadon-Padilla, Lucia; Fernandez-Pelayo, Uxoa; Perez-Rodriguez, Diego; Ramos-Cabrer, Pedro; Spinazzola, Antonella; Elortza, Félix; Ruíz-Cabello, Jésus; Holt, Ian J

Role of Bradykinin Type 2 Receptors in Human Sweat Secretion: Translational Evidence Does Not Support a Functional Relationship

缓激肽2型受体在人类汗液分泌中的作用:转化证据不支持其功能关系

Wilson, Thad E; Narra, Seetharam; Metzler-Wilson, Kristen; Schneider, Artur; Bullens, Kelsey A; Holt, Ian S

Recurrent De Novo NAHR Reciprocal Duplications in the ATAD3 Gene Cluster Cause a Neurogenetic Trait with Perturbed Cholesterol and Mitochondrial Metabolism

ATAD3基因簇中反复发生的从头NAHR相互重复导致一种神经遗传特征,该特征与胆固醇和线粒体代谢紊乱有关。

Gunning, Adam C; Strucinska, Klaudia; Muñoz Oreja, Mikel; Parrish, Andrew; Caswell, Richard; Stals, Karen L; Durigon, Romina; Durlacher-Betzer, Karina; Cunningham, Mitchell H; Grochowski, Christopher M; Baptista, Julia; Tysoe, Carolyn; Baple, Emma; Lahiri, Nayana; Homfray, Tessa; Scurr, Ingrid; Armstrong, Catherine; Dean, John; Fernandez Pelayo, Uxoa; Jones, Aleck W E; Taylor, Robert W; Misra, Vinod K; Yoon, Wan Hee; Wright, Caroline F; Lupski, James R; Spinazzola, Antonella; Harel, Tamar; Holt, Ian J; Ellard, Sian

MRPS25 mutations impair mitochondrial translation and cause encephalomyopathy

MRPS25基因突变会损害线粒体翻译并导致脑肌病。

Bugiardini, Enrico; Mitchell, Alice L; Rosa, Ilaria Dalla; Horning-Do, Hue-Tran; Pitmann, Alan M; Poole, Olivia V; Holton, Janice L; Shah, Sachit; Woodward, Cathy; Hargreaves, Iain; Quinlivan, Rosaline; Amunts, Alexey; Wiesner, Rudolf J; Houlden, Henry; Holt, Ian J; Hanna, Michael G; Pitceathly, Robert D S; Spinazzola, Antonella

Adolescent Intermittent Ethanol Increases the Sensitivity to the Reinforcing Properties of Ethanol and the Expression of Select Cholinergic and Dopaminergic Genes within the Posterior Ventral Tegmental Area

青少年间歇性摄入乙醇会增加对乙醇强化作用的敏感性,并增加后腹侧被盖区内特定胆碱能和多巴胺能基因的表达。

Hauser, Sheketha R; Knight, Christopher P; Truitt, William A; Waeiss, Robert Aaron; Holt, Ian S; Carvajal, Gustavo B; Bell, Richard L; Rodd, Zachary A