日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Immunotherapy of cytomegalovirus infection by low-dose adoptive transfer of antiviral CD8 T cells relies on substantial post-transfer expansion of central memory cells but not effector-memory cells

低剂量过继转移抗病毒CD8 T细胞治疗巨细胞病毒感染的免疫疗法依赖于转移后中央记忆细胞的大量扩增,而非效应记忆细胞的扩增。

Holtappels, Rafaela; Becker, Sara; Hamdan, Sara; Freitag, Kirsten; Podlech, Jürgen; Lemmermann, Niels A; Reddehase, Matthias J

Cytomegalovirus immune evasion sets the functional avidity threshold for protection by CD8 T cells

巨细胞病毒的免疫逃逸决定了CD8 T细胞保护作用的功能性亲和力阈值。

Hamdan, Sara; Reddehase, Matthias J; Holtappels, Rafaela

Memory CD8 T Cells Protect against Cytomegalovirus Disease by Formation of Nodular Inflammatory Foci Preventing Intra-Tissue Virus Spread

记忆性CD8 T细胞通过形成结节性炎症灶来抵抗巨细胞病毒感染,从而阻止病毒在组织内扩散。

Holtappels, Rafaela; Podlech, Jürgen; Freitag, Kirsten; Lemmermann, Niels A; Reddehase, Matthias J

Therapeutic Vaccination of Hematopoietic Cell Transplantation Recipients Improves Protective CD8 T-Cell Immunotherapy of Cytomegalovirus Infection

造血干细胞移植受者接受治疗性疫苗接种可增强巨细胞病毒感染的保护性CD8 T细胞免疫疗法

Gergely, Kerstin M; Podlech, Jürgen; Becker, Sara; Freitag, Kirsten; Krauter, Steffi; Büscher, Nicole; Holtappels, Rafaela; Plachter, Bodo; Reddehase, Matthias J; Lemmermann, Niels A W

Immunodominant Cytomegalovirus Epitopes Suppress Subdominant Epitopes in the Generation of High-Avidity CD8 T Cells

免疫优势巨细胞病毒表位抑制亚优势表位,从而促进高亲和力CD8 T细胞的生成

Freitag, Kirsten; Hamdan, Sara; Reddehase, Matthias J; Holtappels, Rafaela

Insufficient Antigen Presentation Due to Viral Immune Evasion Explains Lethal Cytomegalovirus Organ Disease After Allogeneic Hematopoietic Cell Transplantation.

病毒免疫逃逸导致抗原呈递不足,从而解释了同种异体造血细胞移植后致命的巨细胞病毒器官疾病

Holtappels Rafaela, Schader Sina I, Oettel Oliver, Podlech Jürgen, Seckert Christof K, Reddehase Matthias J, Lemmermann Niels A W

Exogenous TNFR2 activation protects from acute GvHD via host T reg cell expansion

外源性TNFR2激活通过宿主Treg细胞扩增来预防急性移植物抗宿主病(GvHD)。

Chopra, Martin; Biehl, Marlene; Steinfatt, Tim; Brandl, Andreas; Kums, Juliane; Amich, Jorge; Vaeth, Martin; Kuen, Janina; Holtappels, Rafaela; Podlech, Jürgen; Mottok, Anja; Kraus, Sabrina; Jordán-Garrote, Ana-Laura; Bäuerlein, Carina A; Brede, Christian; Ribechini, Eliana; Fick, Andrea; Seher, Axel; Polz, Johannes; Ottmüller, Katja J; Baker, Jeanette; Nishikii, Hidekazu; Ritz, Miriam; Mattenheimer, Katharina; Schwinn, Stefanie; Winter, Thorsten; Schäfer, Viktoria; Krappmann, Sven; Einsele, Hermann; Müller, Thomas D; Reddehase, Matthias J; Lutz, Manfred B; Männel, Daniela N; Berberich-Siebelt, Friederike; Wajant, Harald; Beilhack, Andreas

Reconstitution of CD8 T Cells Protective against Cytomegalovirus in a Mouse Model of Hematopoietic Cell Transplantation: Dynamics and Inessentiality of Epitope Immunodominance

在造血细胞移植小鼠模型中重建对巨细胞病毒具有保护作用的CD8 T细胞:表位免疫优势的动态和非必要性

Holtappels, Rafaela; Lemmermann, Niels A W; Podlech, Jürgen; Ebert, Stefan; Reddehase, Matthias J

TCR-ligand koff rate correlates with the protective capacity of antigen-specific CD8+ T cells for adoptive transfer

TCR配体解离速率与抗原特异性CD8+ T细胞过继转移的保护能力相关

Nauerth, Magdalena; Weißbrich, Bianca; Knall, Robert; Franz, Tobias; Dössinger, Georg; Bet, Jeannette; Paszkiewicz, Paulina J; Pfeifer, Lukas; Bunse, Mario; Uckert, Wolfgang; Holtappels, Rafaela; Gillert-Marien, Dorothea; Neuenhahn, Michael; Krackhardt, Angela; Reddehase, Matthias J; Riddell, Stanley R; Busch, Dirk H

Two antigenic peptides from genes m123 and m164 of murine cytomegalovirus quantitatively dominate CD8 T-cell memory in the H-2d haplotype

来自鼠巨细胞病毒m123和m164基因的两种抗原肽在H-2d单倍型中对CD8 T细胞记忆起着数量上的优势作用。

Holtappels, Rafaela; Thomas, Doris; Podlech, Jürgen; Reddehase, Matthias J