日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Predicting onset of symptomatic Alzheimer's disease with plasma p-tau217 clocks

利用血浆p-tau217时钟预测症状性阿尔茨海默病的发病

Petersen, Kellen K; Milà-Alomà, Marta; Li, Yan; Du, Lianlian; Xiong, Chengjie; Tosun, Duygu; Saef, Benjamin; Saad, Ziad S; Du-Cuny, Lei; Coomaraswamy, Janaky; Mordashova, Yulia; Rubel, Carrie E; Meyers, Emily A; Shaw, Leslie M; Dage, Jeffrey L; Ashton, Nicholas J; Zetterberg, Henrik; Ferber, Kyle; Triana-Baltzer, Gallen; Baratta, Michael; Rosenbaugh, Erin G; Cruchaga, Carlos; McDade, Eric; Holtzman, David M; Morris, John C; Sabandal, J Martin; Bateman, Randall J; Bannon, Anthony W; Potter, William Z; Schindler, Suzanne E

Large-scale CSF and plasma proteomics reveal immune, synaptic, and extracellular matrix disruptions across neurodegenerative diseases

大规模脑脊液和血浆蛋白质组学分析揭示了神经退行性疾病中免疫、突触和细胞外基质的紊乱。

Ali, Muhammad; Timsina, Jigyasha; Xu, Ying; Chen, Yike; Gong, Katherine; Western, Daniel; Heo, Gyujin; Liu, Menghan; Budde, John; Pottier, Cyril; Schindler, Suzanne E; Morris, John C; Holtzman, David M; Puerta, Raquel; Cano, Amanda; Boada, Merce; Fernandez, Maria V; Ruiz, Agustin; Aguilar, Miquel; Alvarez, Ignacio; Pastor, Pau; Perlmutter, Joel S; Campbell, Meghan C; Kotzbauer, Paul T; Oh, Hamilton Se-Hwee; Wilson, Edward N; Guen, Yann Le; Tarawneh, Rawan; Wyss-Coray, Tony; Sung, Yun Ju; Ibanez, Laura; Cruchaga, Carlos

APOE-stratified Proteomic and Metabolomic Analysis Reveals Mitochondrial Dysfunction Inflammation and Lipid Dysregulation in Alzheimer's Disease

基于APOE分层的蛋白质组学和代谢组学分析揭示了阿尔茨海默病中的线粒体功能障碍、炎症和脂质代谢紊乱

Li, Fuhai; Chen, Yike; Western, Daniel; Ali, Muhammad; Liu, Menghan; Gong, Katherine; Xu, Ying; Lowery, Joseph; Holtzman, David M; Robins, Chloe; Eicher, John D; Huang, Yen-Ning; Liu, ShiWei; Park, Tamina; Saykin, Andrew J; Nho, Kwangsik; Moqri, Mahdi; Mohs, Richard C; Farinas, Amelia; Moran-Losada, Patricia; Oh, Hamilton Se-Hwee; Wyss-Coray, Tony; Cruchaga, Carlos

GPND-AI NULISA: A 15-Protein AI classifier for diagnosis and co-pathology profiling across neurodegenerative diseases

GPND-AI NULISA:一种用于神经退行性疾病诊断和共病理分析的15种蛋白质人工智能分类器

Xu, Ying; Denkinger, Marisa N; Liu, Menghan; Gong, Katherine; Chen, Yike; Western, Daniel; Timsina, Jigyasha; Cheng, Yuchen; Xie, Yunchang; Mu, Rui; Budde, John; Beach, Thomas G; Serrano, Geidy E; Reiman, Eric M; Singh, Alpana; Alfradique-Dunham, Isabel; Benzinger, Tammie L S; Schindler, Suzanne E; Morris, John C; Holtzman, David M; Perlumtter, Joel S; Snider, B Joy; Campbell, Meghan C; Kotzbauer, Paul T; Ashton, Nicholas J; Cruchaga, Carlos

Analyses of plasma multi-omic data across ancestries identify novel pathways implicated in Alzheimer's disease

对不同种族人群血浆多组学数据的分析揭示了与阿尔茨海默病相关的新通路

Yang, Chengran; Timsina, Jigyasha; Liu, Menghan; Budde, John; Kohlfeld, Pat; Brock, William; Morris, John C; Holtzman, David M; Sung, Yun Ju; Cruchaga, Carlos

Inducible deletion of DGAT1 and 2 from microglia exacerbates neurodegeneration and endolysosomal lipid accumulation in male PS19 mice.

诱导性删除小胶质细胞中的 DGAT1 和 2 会加剧雄性 PS19 小鼠的神经退行性变和内溶酶体脂质积累。

Tabor G Travis, Litvinchuk Alexandra, Chen Yun, Allison Austin, Sun Elizabeth W, van Lengerich Bettina, Davis Sonnet S, West Elizabeth, Schlachetzki Johannes C M, Zeng Carisa, Hu Hao, Lin Peter B, Sharma Prabal, Chen Xiaoying, Parhizkar Samira, Song Sihui, Bao Xin, Senthil Lakshita, Iyer Abhirami K, You Shih Feng, Serrano Javier Remolina, Manis Melissa, Franke Emily, Cashikar Anil G, Yuede Carla M, Suh Jung H, Karch Celeste M, Folick Andrew, Koliwad Suneil K, Farese Robert V Jr, Walther Tobias, Huang Eric J, Artyomov Maxim, Glass Christopher K, Di Paolo Gilbert, Ulrich Jason D, Holtzman David M

Context matters: Conflicting roles of interferon-γ signaling in CNS diseases

背景很重要:干扰素-γ信号在中枢神经系统疾病中的矛盾作用

Nulman, Jonathan; Ulrich, Jason D; Holtzman, David M

Lipidome and proteome of astrocyte and microglia ApoE lipoprotein reveal differences based on cell type and ApoE isoform.

星形胶质细胞和小胶质细胞 ApoE 脂蛋白的脂质组和蛋白质组揭示了基于细胞类型和 ApoE 同型异构体的差异。

Strickland Michael R, Wang Zhen, Golden Lesley R, Wang Hu, Lu Ping, Ren Yingxue, Tabor G Travis, Zhao Na, Ulrich Jason D, Han Xianlin, Peng Junmin, Holtzman David M

CSF turnover reshapes biomarker interpretation in neurodegeneration studies

脑脊液周转重塑神经退行性疾病研究中生物标志物的解读

García-González, Pablo; Puerta, Raquel; Dehairs, Jonas; Yang, Chengran; Wang, Ciyang; Timsina, Jigyasha; de Rojas, Itziar; Olivé, Claudia; Valenzuela, Alejandro; Bayón-Buján, Paula; Rovira, Marta; Montrreal, Laura; Capdevila, Maria; Muñoz-Morales, Álvaro; Calm, Berta; Valero, Sergi; Alegret, Montse; Marquié, Marta; Morris, John C; Schindler, Suzanne E; Holtzman, David M; Sanz, Pilar; Tárraga, Lluís; Khan, Asif; Sáez, Maria E; Smets, Bart; Orellana, Adelina; Montalbán, Xavier; Boada, Mercè; Cano, Amanda; Liu, Menghan; Ali, Muhammad; Cruchaga, Carlos; Swinnen, Johannes V; Fernández, Victoria; Cabrera-Socorro, Alfredo; Ruiz, Agustín

Multi-modal choroid plexus pathology in aging and Alzheimer's disease

衰老和阿尔茨海默病中的多模式脉络丛病变

Xu, Huixin; Lotfy, Peter; Englert, Benjamin; Oberhauser, Jane; Byer, Lillian I J; Wihlman, Jasmin; Colangelo, Kia; Okar, Serhat V; Thommana, Ashley; Puttonen, Henri; Mäyränpää, Mikko I; Tuimala, Jarno; Pedrosa, Rute; Kumar, Darshan; Haberberger, James Francis; Atkins, Micaiah Emmy; Alimukhamedov, Shon; Pragana, Aja; Benson, Jordan; Gabrielle, Mary Elizabeth; Dong, Anna; Laforet, Violeta Durán; Lin, Peter Bor-Chian; Keene, C Dirk; Latimer, Caitlin S; Prater, Katherine E; Holtzman, David M; Isakova, Alina; Wyss-Coray, Tony; Schafer, Dorothy P; Reich, Daniel S; Lehtimäki, Terho; Karhunen, Pekka J; Kok, Eloise H; Jansson, Deidre; Yang, Andrew C; Myllykangas, Liisa; Ordovas-Montanes, Jose; Lehtinen, Maria K