日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Streptococcus pneumoniae HtrA is a dynamic and monomeric virulence factor capable of forming larger oligomeric complexes

肺炎链球菌HtrA是一种动态的单体毒力因子,能够形成更大的寡聚复合物。

Lee, Eunjeong; Redzic, Jasmina S; Gordon, Blaine; Saviola, Anthony J; Tran, Norman; Maroney, Sean P; Ashby, Nathanael L; Shaw, Steven; Fulte, Sam; McCarty, Arianna; Holyoak, Todd; Meyer, Nancy; Hansen, Kirk C; Clark, Sarah E; Eisenmesser, Elan

Identifying and controlling inactive and active conformations of a serine protease

识别和控制丝氨酸蛋白酶的非活性和活性构象

Lee, Eunjeong; Tran, Norman; Redzic, Jasmina S; Singh, Harmanpreet; Alamillo, Lorena; Holyoak, Todd; Hamelberg, Donald; Eisenmesser, Elan Zohar

Structure of the Thomasclavelia ramosa immunoglobulin A protease reveals a modular and minimizable architecture distinct from other immunoglobulin A proteases

Thomasclavelia ramosa 免疫球蛋白 A 蛋白酶的结构揭示了一种模块化且可最小化的结构,这与其他免疫球蛋白 A 蛋白酶截然不同。

Tran, Norman; Frenette, Aaron; Holyoak, Todd

The neglected PCK1/glucagon (inter)action in nutrient homeostasis beyond gluconeogenesis: Disease pathogenesis and treatment

被忽视的PCK1/胰高血糖素(相互作用)在糖异生以外的营养稳态中的作用:疾病发病机制和治疗

Bertinat, Romina; Holyoak, Todd; Gatica, Rodrigo; Jara, Nery; González-Chavarría, Iván; Westermeier, Francisco

Structural mechanisms for cold-adapted activity of phosphoenolpyruvate carboxykinase

磷酸烯醇式丙酮酸羧激酶冷适应活性的结构机制

McLeod, Matthew J; Yazdani, Shauhin; Barwell, Sarah A E; Holyoak, Todd

The structure of the Gemella haemolysans M26 IgA1 protease trypsin-like domain

吉氏溶血菌M26 IgA1蛋白酶胰蛋白酶样结构域的结构

Tran, Norman; Redzic, Jasmina S; Eisenmesser, Elan Z; Holyoak, Todd

A structural perspective on the temperature-dependent activity of enzymes

从结构角度探讨酶的温度依赖性活性

McLeod, Matthew J; Barwell, Sarah A E; Holyoak, Todd; Thorne, Robert Edward

A metal-dependent conformational change provides a structural basis for the inhibition of CTP synthase by gemcitabine-5'-triphosphate

金属依赖性构象变化为吉西他滨-5'-三磷酸抑制CTP合酶提供了结构基础。

McLeod, Matthew J; Tran, Norman; McCluskey, Gregory D; Gillis, Tom D; Bearne, Stephen L; Holyoak, Todd

PYK-SubstitutionOME: an integrated database containing allosteric coupling, ligand affinity and mutational, structural, pathological, bioinformatic and computational information about pyruvate kinase isozymes

PYK-SubstitutionOME:一个整合了丙酮酸激酶同工酶的变构偶联、配体亲和力以及突变、结构、病理、生物信息学和计算信息的数据库

Swint-Kruse, Liskin; Dougherty, Larissa L; Page, Braelyn; Wu, Tiffany; O'Neil, Pierce T; Prasannan, Charulata B; Timmons, Cody; Tang, Qingling; Parente, Daniel J; Sreenivasan, Shwetha; Holyoak, Todd; Fenton, Aron W

Millisecond mix-and-quench crystallography (MMQX) enables time-resolved studies of PEPCK with remote data collection

毫秒级混合淬灭晶体学(MMQX)能够利用远程数据采集技术对PEPCK进行时间分辨研究。

Clinger, Jonathan A; Moreau, David W; McLeod, Matthew J; Holyoak, Todd; Thorne, Robert E