日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A monofunctional-like mutant of DNA glycosylase NTHL1 changes the dynamics of DNA repair during acute oxidative stress

DNA糖基化酶NTHL1的单功能样突变体改变了急性氧化应激期间DNA修复的动态过程。

Haslam, James; Rudolfova, Natalie; Zhou, Kaixin; Homan, Evert; Jemth, Ann-Sofie; Michel, Maurice; Helleday, Thomas; Mortusewicz, Oliver

Nucleobase catalysts for the enzymatic activation of 8-oxoguanine DNA glycosylase 1

核碱基催化剂用于8-氧鸟嘌呤DNA糖基化酶1的酶促活化

Hank, Emily C; D'Arcy-Evans, Nicholas D; Scaletti, Emma Rose; Benítez-Buelga, Carlos; Wallner, Olov; Ortis, Florian; Zhou, Kaixin; Meng, Liuzhen; Del Prado, Alicia; Calvo, Patricia; Almlöf, Ingrid; Wiita, Elisée; Nierlin, Karen; Košenina, Sara; Krämer, Andreas; Eddershaw, Alice; Kehler, Mario; Long, Maeve; Jemth, Ann-Sofie; Dawson, Holly; Stewart, Josephine; Dickey, Adam; Astorga, Mikhael E; Varga, Marek; Homan, Evert J; Scobie, Martin; Knapp, Stefan; Sastre, Leandro; Stenmark, Pål; de Vega, Miguel; Helleday, Thomas; Michel, Maurice

Virtual fragment screening for DNA repair inhibitors in vast chemical space.

在广阔的化学空间中对DNA修复抑制剂进行虚拟片段筛选

Luttens Andreas, Vo Duc Duy, Scaletti Emma R, Wiita Elisée, Almlöf Ingrid, Wallner Olov, Davies Jonathan, Košenina Sara, Meng Liuzhen, Long Maeve, Mortusewicz Oliver, Masuyer Geoffrey, Ballante Flavio, Michel Maurice, Homan Evert, Scobie Martin, Kalderén Christina, Warpman Berglund Ulrika, Tarnovskiy Andrii V, Radchenko Dmytro S, Moroz Yurii S, Kihlberg Jan, Stenmark Pål, Helleday Thomas, Carlsson Jens

Giving an Enzyme Scissors: Serotonin Derivatives as Potent Organocatalytic Switches for DNA Repair Enzyme OGG1

赋予酶剪刀:血清素衍生物作为DNA修复酶OGG1的强效有机催化开关

Varga, Marek; Ortis, Florian; Del Prado, Alicia; Eddershaw, Alice; Scaletti Hutchinson, Emma; Hank, Emily C; Zhou, Kaixin; Rudolfová, Natálie; Dodaro, Alessia; Wiita, Elisée; Almlöf, Ingrid; Karsten, Stella; Mamonov, Kirill; Ahmed, Sara H; Bentley, Kirsty; Wallner, Olov; Homan, Evert J; Scobie, Martin; Helleday, Thomas; Prejanò, Mario; Stenmark, Pål; de Vega, Miguel; Watson, Allan J B; Michel, Maurice

Organocatalytic Switches of DNA Glycosylase OGG1 Catalyze a Highly Efficient AP-Lyase Function

DNA糖基化酶OGG1的有机催化开关可催化高效的AP裂解酶功能

Kehler, Mario; Zhou, Kaixin; Kemas, Aurino M; Del Prado, Alicia; Hutchinson, Emma Scaletti; Nairn, Elinor Hesslefors; Varga, Marek; Plattner, Yvonne; Zhong, Yi; Purewal-Sidhu, Oryn; Haslam, James; Wiita, Elisée; Gildie, Heather; Singerova, Karolina; Szaruga, Zuzanna; Almlöf, Ingrid; Hormann, Femke M; Liu, Kang-Cheng; Wallner, Olov; Ortis, Florian; Homan, Evert J; Gileadi, Opher; Rudd, Sean G; Stenmark, Pål; de Vega, Miguel; Helleday, Thomas; D'Arcy-Evans, Nicholas D; Lauschke, Volker M; Michel, Maurice

Target 2035 - an update on private sector contributions

2035年目标——私营部门贡献的最新情况

Ackloo, Suzanne; Antolin, Albert A; Bartolome, Jose Manuel; Beck, Hartmut; Bullock, Alex; Betz, Ulrich A K; Böttcher, Jark; Brown, Peter J; Chaturvedi, Menorca; Crisp, Alisa; Daniels, Danette; Dreher, Jan; Edfeldt, Kristina; Edwards, Aled M; Egner, Ursula; Elkins, Jon; Fischer, Christian; Glendorf, Tine; Goldberg, Steven; Hartung, Ingo V; Hillisch, Alexander; Homan, Evert; Knapp, Stefan; Köster, Markus; Krämer, Oliver; Llaveria, Josep; Lessel, Uta; Lindemann, Sven; Linderoth, Lars; Matsui, Hisanori; Michel, Maurice; Montel, Florian; Mueller-Fahrnow, Anke; Müller, Susanne; Owen, Dafydd R; Saikatendu, Kumar Singh; Santhakumar, Vijayaratnam; Sanderson, Wendy; Scholten, Cora; Schapira, Matthieu; Sharma, Sujata; Shireman, Brock; Sundström, Michael; Todd, Matthew H; Tredup, Claudia; Venable, Jennifer; Willson, Timothy M; Arrowsmith, Cheryl H

Target 2035 - update on the quest for a probe for every protein

2035年目标——为每种蛋白质寻找探针的最新进展

Müller, Susanne; Ackloo, Suzanne; Al Chawaf, Arij; Al-Lazikani, Bissan; Antolin, Albert; Baell, Jonathan B; Beck, Hartmut; Beedie, Shaunna; Betz, Ulrich A K; Bezerra, Gustavo Arruda; Brennan, Paul E; Brown, David; Brown, Peter J; Bullock, Alex N; Carter, Adrian J; Chaikuad, Apirat; Chaineau, Mathilde; Ciulli, Alessio; Collins, Ian; Dreher, Jan; Drewry, David; Edfeldt, Kristina; Edwards, Aled M; Egner, Ursula; Frye, Stephen V; Fuchs, Stephen M; Hall, Matthew D; Hartung, Ingo V; Hillisch, Alexander; Hitchcock, Stephen H; Homan, Evert; Kannan, Natarajan; Kiefer, James R; Knapp, Stefan; Kostic, Milka; Kubicek, Stefan; Leach, Andrew R; Lindemann, Sven; Marsden, Brian D; Matsui, Hisanori; Meier, Jordan L; Merk, Daniel; Michel, Maurice; Morgan, Maxwell R; Mueller-Fahrnow, Anke; Owen, Dafydd R; Perry, Benjamin G; Rosenberg, Saul H; Saikatendu, Kumar Singh; Schapira, Matthieu; Scholten, Cora; Sharma, Sujata; Simeonov, Anton; Sundström, Michael; Superti-Furga, Giulio; Todd, Matthew H; Tredup, Claudia; Vedadi, Masoud; von Delft, Frank; Willson, Timothy M; Winter, Georg E; Workman, Paul; Arrowsmith, Cheryl H

The First Structure of Human MTHFD2L and Its Implications for the Development of Isoform-Selective Inhibitors.

人类 MTHFD2L 的第一个结构及其对亚型选择性抑制剂开发的意义

Scaletti Emma R, Gustafsson Westergren Robert, Andersson Yasmin, Wiita Elisee, Henriksson Martin, Homan Evert J, Jemth Ann-Sofie, Helleday Thomas, Stenmark PÃ¥l

Crystal structures of NUDT15 variants enabled by a potent inhibitor reveal the structural basis for thiopurine sensitivity

利用强效抑制剂解析的NUDT15变体晶体结构揭示了硫嘌呤敏感性的结构基础。

Rehling, Daniel; Zhang, Si Min; Jemth, Ann-Sofie; Koolmeister, Tobias; Throup, Adam; Wallner, Olov; Scaletti, Emma; Moriyama, Takaya; Nishii, Rina; Davies, Jonathan; Desroses, Matthieu; Rudd, Sean G; Scobie, Martin; Homan, Evert; Berglund, Ulrika Warpman; Yang, Jun J; Helleday, Thomas; Stenmark, Pål

In silico Druggability Assessment of the NUDIX Hydrolase Protein Family as a Workflow for Target Prioritization

利用计算机模拟方法对NUDIX水解酶蛋白家族进行成药性评估,作为靶点优先级排序的工作流程

Michel, Maurice; Homan, Evert J; Wiita, Elisée; Pedersen, Kia; Almlöf, Ingrid; Gustavsson, Anna-Lena; Lundbäck, Thomas; Helleday, Thomas; Warpman Berglund, Ulrika