Homanics Gregg E相关文献与解析，生知库 | 链接生命科学的每一步

Guizzetti, Marina; Mangieri, Regina A; Ezerskiy, Lubov A; Hashimoto, Joel G; Bajo, Michal; Farris, Sean P; Homanics, Gregg E; Lasek, Amy W; Mayfield, R Dayne; Messing, Robert O; Roberto, Marisa

胶质细胞

细胞生物学

发表日期：2026

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An increased copy number of glycine decarboxylase (GLDC) associated with psychosis reduces extracellular glycine and impairs NMDA receptor function

精神病患者体内甘氨酸脱羧酶 (GLDC) 拷贝数增加，导致细胞外甘氨酸水平降低，并损害 NMDA 受体功能。

期刊:Molecular Psychiatry

影响因子:10.1

doi:10.1038/s41380-024-02711-5

Kambali, Maltesh; Li, Yan; Unichenko, Petr; Feria Pliego, Jessica A; Yadav, Rachita; Liu, Jing; McGuinness, Patrick; Cobb, Johanna G; Wang, Muxiao; Nagarajan, Rajasekar; Lyu, Jinrui; Vongsouthi, Vanessa; Jackson, Colin J; Engin, Elif; Coyle, Joseph T; Shin, Jaeweon; Hodgson, Nathaniel W; Hensch, Takao K; Talkowski, Michael E; Homanics, Gregg E; Bolshakov, Vadim Y; Henneberger, Christian; Rudolph, Uwe

Newly Identified TPI Deficiency Treatments Function for Novel Disease-Causing Allele, TPI1(R5G).

新发现的 TPI 缺乏症治疗方法针对新的致病等位基因 TPI1(R5G)。

期刊:Genes

影响因子:2.8

doi:10.3390/genes16101205

Figura Joseph R, Roberts Presley, Sawka Riley, Chambers Maci, Claudio Marcelo, Vollmer Laura L, Vogt Andreas, Homanics Gregg E, van Beers Eduard, Donge Mylene, Scalais Emmanuel, Sorlin Arthur, Jou Ariana J, VanDemark Andrew P, Palladino Michael J

发表日期：2025

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Discovery and validation of small molecule stabilizers of mutant triose phosphate isomerase (TPI) as potential lead candidates for TPI deficiency

发现并验证突变型磷酸丙糖异构酶 (TPI) 小分子稳定剂作为 TPI 缺乏症的潜在先导化合物

期刊:SLAS Discovery

影响因子:2.7

doi:10.1016/j.slasd.2025.100278

Vollmer, Laura L; Roberts, Presley; Eicher, Samantha L; Wołosowicz, Marta; Patel, Priyal; Figura, Joseph R; Donahue, Ella R; Berkowitz, Josh; Gavlock, Dillon; Wipf, Peter; LaPorte, Matt; Mullett, Steven J; Shillington, Amelle; Homanics, Gregg E; Palladino, Michael J; Vogt, Andreas

发表日期：2025

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Changes in ethanol effects in knock-in mice expressing ethanol insensitive alpha1 and alpha2 glycine receptor subunits

表达乙醇不敏感的α1和α2甘氨酸受体亚基的敲入小鼠中乙醇效应的变化

期刊:Life Sciences

影响因子:5.1

doi:10.1016/j.lfs.2024.122673

San Martin, Loreto S; Armijo-Weingart, Lorena; Gallegos, Scarlet; Araya, Anibal; Homanics, Gregg E; Aguayo, Luis G

信号转导

发表日期：2024

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Inter- and transgenerational heritability of preconception chronic stress or alcohol exposure: Translational outcomes in brain and behavior

孕前慢性应激或酒精暴露的代际和跨代遗传性：大脑和行为的转化结果

期刊:Neurobiology of Stress

影响因子:3.6

doi:10.1016/j.ynstr.2023.100603

Rice, Rachel C; Gil, Daniela V; Baratta, Annalisa M; Frawley, Remy R; Hill, Shirley Y; Farris, Sean P; Homanics, Gregg E

神经科学

发表日期：2024

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A Kalirin missense mutation enhances dendritic RhoA signaling and leads to regression of cortical dendritic arbors across development.

Kalirin 错义突变增强了树突 RhoA 信号传导，导致发育过程中皮质树突分支退化

期刊:Proceedings of the National Academy of Sciences of the United States of America

影响因子:9.1

doi:10.1073/pnas.2022546118

Grubisha Melanie J, Sun Tao, Eisenman Leanna, Erickson Susan L, Chou Shinnyi, Helmer Cassandra D, Trudgen Melody T, Ding Ying, Homanics Gregg E, Penzes Peter, Wills Zachary P, Sweet Robert A

The escalation in ethanol consumption following chronic intermittent ethanol exposure is blunted in mice expressing ethanol-resistant GluN1 or GluN2A NMDA receptor subunits

在表达耐乙醇的GluN1或GluN2A NMDA受体亚基的小鼠中，慢性间歇性乙醇暴露后乙醇摄入量的增加被抑制。

期刊:Psychopharmacology

影响因子:3.3

doi:10.1007/s00213-020-05680-z

Zamudio, Paula A; Gioia, Dominic A; Lopez, Marcelo; Homanics, Gregg E; Woodward, John J

信号转导

发表日期：2021

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Gabra2 is a genetic modifier of Dravet syndrome in mice

Gabra2是小鼠Dravet综合征的遗传修饰因子。

期刊:Mammalian Genome

影响因子:2.7

doi:10.1007/s00335-021-09877-1

Hawkins, Nicole A; Nomura, Toshihiro; Duarte, Samantha; Barse, Levi; Williams, Robert W; Homanics, Gregg E; Mulligan, Megan K; Contractor, Anis; Kearney, Jennifer A

发表日期：2021

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A quantitative trait variant in Gabra2 underlies increased methamphetamine stimulant sensitivity

Gabra2基因中的一个数量性状变异与甲基苯丙胺兴奋剂敏感性增加有关。

期刊:Genes Brain and Behavior

影响因子:2.3

doi:10.1111/gbb.12774

Goldberg, Lisa R; Yao, Emily J; Kelliher, Julia C; Reed, Eric R; Wu Cox, Jiayi; Parks, Cory; Kirkpatrick, Stacey L; Beierle, Jacob A; Chen, Melanie M; Johnson, William E; Homanics, Gregg E; Williams, Robert W; Bryant, Camron D; Mulligan, Megan K

发表日期：2021

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Astrocytes and Alcohol Throughout the Lifespan

星形胶质细胞与酒精在整个生命周期中的关系

An increased copy number of glycine decarboxylase (GLDC) associated with psychosis reduces extracellular glycine and impairs NMDA receptor function

精神病患者体内甘氨酸脱羧酶 (GLDC) 拷贝数增加，导致细胞外甘氨酸水平降低，并损害 NMDA 受体功能。

Newly Identified TPI Deficiency Treatments Function for Novel Disease-Causing Allele, TPI1(R5G).

新发现的 TPI 缺乏症治疗方法针对新的致病等位基因 TPI1(R5G)。

Discovery and validation of small molecule stabilizers of mutant triose phosphate isomerase (TPI) as potential lead candidates for TPI deficiency

发现并验证突变型磷酸丙糖异构酶 (TPI) 小分子稳定剂作为 TPI 缺乏症的潜在先导化合物

Changes in ethanol effects in knock-in mice expressing ethanol insensitive alpha1 and alpha2 glycine receptor subunits

表达乙醇不敏感的α1和α2甘氨酸受体亚基的敲入小鼠中乙醇效应的变化

Inter- and transgenerational heritability of preconception chronic stress or alcohol exposure: Translational outcomes in brain and behavior

孕前慢性应激或酒精暴露的代际和跨代遗传性：大脑和行为的转化结果

A Kalirin missense mutation enhances dendritic RhoA signaling and leads to regression of cortical dendritic arbors across development.

Kalirin 错义突变增强了树突 RhoA 信号传导，导致发育过程中皮质树突分支退化

The escalation in ethanol consumption following chronic intermittent ethanol exposure is blunted in mice expressing ethanol-resistant GluN1 or GluN2A NMDA receptor subunits

在表达耐乙醇的GluN1或GluN2A NMDA受体亚基的小鼠中，慢性间歇性乙醇暴露后乙醇摄入量的增加被抑制。

Gabra2 is a genetic modifier of Dravet syndrome in mice

Gabra2是小鼠Dravet综合征的遗传修饰因子。

A quantitative trait variant in Gabra2 underlies increased methamphetamine stimulant sensitivity

Gabra2基因中的一个数量性状变异与甲基苯丙胺兴奋剂敏感性增加有关。