Circ-ITCH promotes the ubiquitination degradation of HOXC10 to facilitate osteogenic differentiation in disuse osteoporosis through stabilizing BRCA1 mRNA via IGF2BP2-mediated m(6)A modification.
Circ-ITCH 通过 IGF2BP2 介导的 m(6)A 修饰稳定 BRCA1 mRNA，从而促进 HOXC10 的泛素化降解，进而促进废用性骨质疏松症中的成骨分化
期刊:Journal of Translational Medicine
影响因子:7.5
doi:10.1186/s12967-024-06050-5
Zhong Da, Li Xi, Yin Zhen, Chen Peng, Li Yusheng, Tian Jian, Wang Long, Liu Hua, Yin Ke, Zhu Lemei, Kong Lingyu, Chen Kunli, Li Yaochun, Hong Chungu, Wang Chenggong
