Hong Wen-Bin相关文献与解析，生知库 | 链接生命科学的每一步

Disruption of heme homeostasis by nuclear receptor Nur77 induces pyroptosis through granzyme B-dependent GSDMC cleavage

核受体Nur77破坏血红素稳态，通过颗粒酶B依赖的GSDMC裂解诱导细胞焦亡。

期刊:Signal Transduction and Targeted Therapy

Wu, Liu-Zheng; Huang, Ya-Ying; Hu, Hai-Jing; Hong, Wen-Bin; Yan, Han; Ai, Yuan-Li; Mi, Xiang-Yu; Feng, De-Yi; Guo, Jian-Yi; Ding, Yang; Liu, Zai-Jun; Zhou, Bo; Xiao, Li; Lin, Tianwei; Li, Fu-Nan; Chen, Xue-Qin; Chen, Hang-Zi; Wu, Qiao

cGAS activation converges with intracellular acidification to promote STING aggregation and pyroptosis in tumor models.

cGAS 激活与细胞内酸化共同促进肿瘤模型中的 STING 聚集和细胞焦亡

期刊:Journal of Clinical Investigation

影响因子:13.6

doi:10.1172/JCI188872

Xiao Li, Ai Yuan-Li, Mi Xiang-Yu, Liang Han, Zhi Xiang, Wu Liu-Zheng, Chen Qi-Tao, Gou Tong, Chen Chao, Zhou Bo, Hong Wen-Bin, Yao Lu-Ming, Chen Jun-Jie, Deng Xianming, Li Fu-Nan, Wu Qiao, Chen Hang-Zi

Activation of AKT via a dual mechanism enhances the susceptibility of melanoma cells to glucose deprivation.

AKT 通过双重机制激活，增强黑色素瘤细胞对葡萄糖缺乏的敏感性

期刊:Cell Death & Disease

影响因子:9.6

doi:10.1038/s41419-025-07906-4

Yang Guang-Xi, Peng De-Liang, Chen Lin, Qian Yu, He Le, Chen Xiao-Yan, Hong Wen-Bin, Wu Cai-Ming, Chen Hang-Zi

Blocking PPARγ interaction facilitates Nur77 interdiction of fatty acid uptake and suppresses breast cancer progression

阻断PPARγ相互作用可促进Nur77对脂肪酸摄取的抑制，从而抑制乳腺癌进展。

期刊:Proceedings of the National Academy of Sciences of the United States of America

影响因子:9.1

doi:10.1073/pnas.2002997117

Yang, Peng-Bo; Hou, Pei-Pei; Liu, Fu-Yuan; Hong, Wen-Bin; Chen, Hang-Zi; Sun, Xiao-Yu; Li, Peng; Zhang, Yi; Ju, Cui-Yu; Luo, Li-Juan; Wu, Sheng-Fu; Zhou, Jia-Xin; Wang, Zhi-Jing; He, Jian-Ping; Li, Li; Zhao, Tong-Jin; Deng, Xianming; Lin, Tianwei; Wu, Qiao

ITM2B Truncation Promotes Migrasome Formation to Accelerate Renal Cell Carcinoma Growth.

ITM2B 截断促进迁移体形成，从而加速肾细胞癌的生长。

Disruption of heme homeostasis by nuclear receptor Nur77 induces pyroptosis through granzyme B-dependent GSDMC cleavage

核受体Nur77破坏血红素稳态，通过颗粒酶B依赖的GSDMC裂解诱导细胞焦亡。

cGAS activation converges with intracellular acidification to promote STING aggregation and pyroptosis in tumor models.

cGAS 激活与细胞内酸化共同促进肿瘤模型中的 STING 聚集和细胞焦亡

Activation of AKT via a dual mechanism enhances the susceptibility of melanoma cells to glucose deprivation.

AKT 通过双重机制激活，增强黑色素瘤细胞对葡萄糖缺乏的敏感性

Blocking PPARγ interaction facilitates Nur77 interdiction of fatty acid uptake and suppresses breast cancer progression

阻断PPARγ相互作用可促进Nur77对脂肪酸摄取的抑制，从而抑制乳腺癌进展。