日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Randomized clinical efficacy and safety study of peltopepimut-S plus cemiplimab compared to cemiplimab alone in patients with recurrent/metastatic HPV16-positive head and neck cancer

一项随机临床疗效和安全性研究,比较了peltopepimut-S联合cemiplimab与单用cemiplimab治疗复发/转移性HPV16阳性头颈癌患者的疗效和安全性。

Even, Caroline; Harrington, Kevin J; Massarelli, Erminia; Laban, Simon; Fayette, Jérôme; Oliva, Marc; Klein Hesselink, Marielle; Visscher, Sonja; Fury, Matthew G; Wiekmeijer, Anna-Sophia; Licitra, Lisa; Melichar, Bohuslav; Devriese, Lot A; Braña, Irene; Jankowska, Petra; Posner, Marshall; Glisson, Bonnie; Kong, Anthony; Hooftman, Leon; Melief, Cornelis J M MD,; Ferrarotto, Renata

Itaconate drives mtRNA-mediated type I interferon production through inhibition of succinate dehydrogenase.

衣康酸通过抑制琥珀酸脱氢酶来驱动 mtRNA 介导的 I 型干扰素的产生

O'Carroll Shane M, Peace Christian G, Toller-Kawahisa Juliana E, Min Yukun, Hooftman Alexander, Charki Sara, Kehoe Louise, O'Sullivan Maureen J, Zoller Aline, Mcgettrick Anne F, Zotta Alessia, Day Emily A, Simarro Maria, Armstrong Neali, Annes Justin P, O'Neill Luke A J

Macrophage fumarate hydratase restrains mtRNA-mediated interferon production

巨噬细胞富马酸水合酶抑制线粒体RNA介导的干扰素产生

Alexander Hooftman # ,Christian G Peace # ,Dylan G Ryan # ,Emily A Day ,Ming Yang ,Anne F McGettrick ,Maureen Yin ,Erica N Montano ,Lihong Huo ,Juliana E Toller-Kawahisa ,Vincent Zecchini ,Tristram A J Ryan ,Alfonso Bolado-Carrancio ,Alva M Casey ,Hiran A Prag ,Ana S H Costa ,Gabriela De Los Santos ,Mariko Ishimori ,Daniel J Wallace ,Swamy Venuturupalli ,Efterpi Nikitopoulou ,Norma Frizzell ,Cecilia Johansson ,Alexander Von Kriegsheim ,Michael P Murphy ,Caroline Jefferies ,Christian Frezza ,Luke A J O'Neill

Dimethyl fumarate and 4-octyl itaconate are anticoagulants that suppress Tissue Factor in macrophages via inhibition of Type I Interferon

富马酸二甲酯和 4-辛基衣康酸酯是抗凝剂,通过抑制 I 型干扰素来抑制巨噬细胞中的组织因子

Tristram A J Ryan, Alexander Hooftman, Aisling M Rehill, Matt D Johansen, Eóin C O' Brien, Juliana E Toller-Kawahisa, Mieszko M Wilk, Emily A Day, Hauke J Weiss, Pourya Sarvari, Emilio G Vozza, Fabian Schramm, Christian G Peace, Alessia Zotta, Stefan Miemczyk, Christina Nalkurthi, Nicole G Hansbro, 

Basic Mechanisms of Immunometabolites in Shaping the Immune Response

免疫代谢物在塑造免疫反应中的基本机制

Ryan, Dylan Gerard; Peace, Christian Graham; Hooftman, Alexander

What Can We Learn From In-Depth Analysis of Human Errors Resulting in Diagnostic Errors in the Emergency Department: An Analysis of Serious Adverse Event Reports

从对急诊科诊断错误中人为因素造成的错误进行深入分析中,我们能学到什么:一项针对严重不良事件报告的分析

Baartmans, Mees C; Hooftman, Jacky; Zwaan, Laura; van Schoten, Steffie M; Erwich, Jan Jaap H M; Wagner, Cordula

Advancing Diagnostic Safety Research: Results of a Systematic Research Priority Setting Exercise

推进诊断安全研究:系统性研究优先事项设定练习的结果

Zwaan, Laura; El-Kareh, Robert; Meyer, Ashley N D; Hooftman, Jacky; Singh, Hardeep

The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation

免疫调节代谢物衣康酸修饰NLRP3并抑制炎症小体活化

Alexander Hooftman ,Stefano Angiari ,Svenja Hester ,Sarah E Corcoran ,Marah C Runtsch ,Chris Ling ,Melanie C Ruzek ,Peter F Slivka ,Anne F McGettrick ,Kathy Banahan ,Mark M Hughes ,Alan D Irvine ,Roman Fischer ,Luke A J O'Neill

Caspase-11 promotes allergic airway inflammation

Caspase-11促进过敏性呼吸道炎症

Zbigniew Zasłona, Ewelina Flis, Mieszko M Wilk, Richard G Carroll, Eva M Palsson-McDermott, Mark M Hughes, Ciana Diskin, Kathy Banahan, Dylan G Ryan, Alexander Hooftman, Alicja Misiak, Jay Kearney, Gunter Lochnit, Wilhelm Bertrams, Timm Greulich, Bernd Schmeck, Oliver J McElvaney, Kingston H G Mills

The pentose phosphate pathway of cellulolytic clostridia relies on 6-phosphofructokinase instead of transaldolase

纤维素分解梭菌的戊糖磷酸途径依赖于 6-磷酸果糖激酶而非转醛醇酶

Jeroen G Koendjbiharie, Shuen Hon, Martin Pabst, Robert Hooftman, David M Stevenson, Jingxuan Cui, Daniel Amador-Noguez, Lee R Lynd, Daniel G Olson, Richard van Kranenburg