日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

STX4 Is Indispensable for Mitochondrial Homeostasis in Skeletal Muscle

STX4对于骨骼肌线粒体稳态至关重要

Hoolachan, Joseph M; Balakrishnan, Rekha; McCown, Erika M; Merz, Karla E; Zhou, Chunxue; Bloom-Saldana, Elizabeth; Fueger, Patrick T; Hamilton, Angelica; Kiperman, Tali; Ma, Ke; Oh, Eunjin; Jiang, Lei; Pirrotte, Patrick; Shirihai, Orian; Thurmond, Debbie C

TAS1R3 Regulates GTPase Signaling in Human Skeletal Muscle Cells for Glucose Uptake

TAS1R3 调控人骨骼肌细胞中的 GTPase 信号通路以促进葡萄糖摄取

Hoolachan, Joseph M; Balakrishnan, Rekha; Merz, Karla E; Thurmond, Debbie C; Veluthakal, Rajakrishnan

Mifepristone alone and in combination with scAAV9-SMN1 gene therapy improves disease phenotypes in Smn(2B/-) spinal muscular atrophy mice

米非司酮单独使用或与scAAV9-SMN1基因疗法联合使用,均可改善Smn(2B/-)脊髓性肌萎缩症小鼠的疾病表型。

Sutton, Emma R; McCallion, Eve; Hoolachan, Joseph M; Çetin, Özge; Pacheco-Torres, Paloma; Rashid, Saman; Bouhmidi, Sihame; Haynes, Katie; Churchill, Lauren; Scaife, Taylor; Chaytow, Helena; Huang, Yu-Ting; Duguez, Stephanie; Schneider, Bernard L; Gillingwater, Thomas H; Dimitriadi, Maria; Bowerman, Melissa

Exercise, disease state and sex influence the beneficial effects of Fn14-depletion on survival and muscle pathology in the SOD1G93A amyotrophic lateral sclerosis (ALS) mouse model

运动、疾病状态和性别会影响 Fn14 耗竭对 SOD1G93A 肌萎缩侧索硬化症 (ALS) 小鼠模型的生存和肌肉病理的有益影响

Gareth Hazell, Eve McCallion, Nina Ahlskog, Emma R Sutton, Magnus Okoh, Emad I H Shaqoura, Joseph M Hoolachan, Taylor Scaife, Sara Iqbal, Amarjit Bhomra, Anna J Kordala, Frederique Scamps, Cedric Raoul, Matthew J A Wood, Melissa Bowerman

Mitochondrial Dysfunction, Oxidative Stress, and Inter-Organ Miscommunications in T2D Progression

线粒体功能障碍、氧化应激和器官间通讯障碍在2型糖尿病进展中的作用

Veluthakal, Rajakrishnan; Esparza, Diana; Hoolachan, Joseph M; Balakrishnan, Rekha; Ahn, Miwon; Oh, Eunjin; Jayasena, Chathurani S; Thurmond, Debbie C

A transcriptomics-based drug repositioning approach to identify drugs with similar activities for the treatment of muscle pathologies in spinal muscular atrophy (SMA) models

基于转录组学的药物重新定位方法,用于识别具有类似活性的药物,用于治疗脊髓性肌萎缩 (SMA) 模型中的肌肉病变

Joseph M Hoolachan, Eve McCallion, Emma R Sutton, Özge Çetin, Paloma Pacheco-Torres, Maria Dimitriadi, Suat Sari, Gavin J Miller, Magnus Okoh, Lisa M Walter, Peter Claus, Matthew J A Wood, Daniel P Tonge, Melissa Bowerman

Toward Ameliorating Insulin Resistance: Targeting a Novel PAK1 Signaling Pathway Required for Skeletal Muscle Mitochondrial Function

改善胰岛素抵抗:针对骨骼肌线粒体功能所需的新型 PAK1 信号通路

Rekha Balakrishnan, Pablo A Garcia, Rajakrishnan Veluthakal, Janice M Huss, Joseph M Hoolachan, Debbie C Thurmond

Combining multiomics and drug perturbation profiles to identify muscle-specific treatments for spinal muscular atrophy

结合多组学和药物扰动谱来确定脊髓性肌萎缩症的肌肉特异性治疗方法

Katharina E Meijboom, Viola Volpato, Jimena Monzón-Sandoval, Joseph M Hoolachan, Suzan M Hammond, Frank Abendroth, Olivier G de Jong, Gareth Hazell, Nina Ahlskog, Matthew Ja Wood, Caleb Webber, Melissa Bowerman