日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

D-peptide-magnetic nanoparticles fragment tau fibrils and rescue behavioral deficits in a mouse model of Alzheimer's disease

肽磁性纳米粒子碎裂 tau 纤维并挽救阿尔茨海默病小鼠模型中的行为缺陷

Ke Hou, Hope Pan, Hedieh Shahpasand-Kroner, Carolyn Hu, Romany Abskharon, Paul Seidler, Marisa Mekkittikul, Melinda Balbirnie, Carter Lantz, Michael R Sawaya, Joshua L Dolinsky, Mychica Jones, Xiaohong Zuo, Joseph A Loo, Sally Frautschy, Greg Cole, David S Eisenberg

Low complexity domains of the nucleocapsid protein of SARS-CoV-2 form amyloid fibrils

SARS-CoV-2 核衣壳蛋白的低复杂度结构域形成淀粉样蛋白原纤维

Einav Tayeb-Fligelman, Jeannette T Bowler, Christen E Tai, Michael R Sawaya, Yi Xiao Jiang, Gustavo Garcia Jr, Sarah L Griner, Xinyi Cheng, Lukasz Salwinski, Liisa Lutter, Paul M Seidler, Jiahui Lu, Gregory M Rosenberg, Ke Hou, Romany Abskharon, Hope Pan, Chih-Te Zee, David R Boyer, Yan Li, Daniel H

Small molecules disaggregate alpha-synuclein and prevent seeding from patient brain-derived fibrils

小分子分解α-突触核蛋白并阻止患者脑源性纤维的播种

Kevin A Murray, Carolyn J Hu, Hope Pan, Jiahui Lu, Romany Abskharon, Jeannette T Bowler, Gregory M Rosenberg, Christopher K Williams, Gazmend Elezi, Melinda Balbirnie, Kym F Faull, Harry V Vinters, Paul M Seidler, David S Eisenberg

Structure-based design of nanobodies that inhibit seeding of Alzheimer's patient-extracted tau fibrils

基于结构的设计纳米抗体可抑制阿尔茨海默病患者提取的 tau 纤维的播种

Romany Abskharon #, Hope Pan #, Michael R Sawaya, Paul M Seidler, Eileen J Olivares, Yu Chen, Kevin A Murray, Jeffrey Zhang, Carter Lantz, Megan Bentzel, David R Boyer, Duilio Cascio, Binh A Nguyen, Ke Hou, Xinyi Cheng, Els Pardon, Christopher K Williams, Alissa L Nana, Harry V Vinters, Salvatore Sp

Identifying amyloid-related diseases by mapping mutations in low-complexity protein domains to pathologies

通过将低复杂度蛋白质结构域中的突变映射到病理来识别淀粉样蛋白相关疾病

Kevin A Murray, Michael P Hughes, Carolyn J Hu, Michael R Sawaya, Lukasz Salwinski, Hope Pan, Samuel W French, Paul M Seidler, David S Eisenberg

Minocycline alleviates depression-like symptoms by rescuing decrease in neurogenesis in dorsal hippocampus via blocking microglia activation/phagocytosis

米诺环素通过阻断小胶质细胞活化/吞噬作用来挽救背海马神经发生的减少,从而缓解抑郁样症状

Ben Bassett, Selvaraj Subramaniyam, Yang Fan, Seth Varney, Hope Pan, Ana M D Carneiro, Chang Y Chung

Anti-inflammaging effects of human alpha-1 antitrypsin

人类 α-1 抗胰蛋白酶的抗炎作用

Ye Yuan, Benedetto DiCiaccio, Ying Li, Ahmed S Elshikha, Denis Titov, Brian Brenner, Lee Seifer, Hope Pan, Nurdina Karic, Mohammad A Akbar, Yuanqing Lu, Sihong Song, Lei Zhou

The Gain-of-Function Integrin β3 Pro33 Variant Alters the Serotonin System in the Mouse Brain

获得功能整合素 β3 Pro33 变体改变小鼠大脑中的血清素系统

Michael R Dohn, Christopher G Kooker, Lisa Bastarache, Tammy Jessen, Capria Rinaldi, Seth Varney, Matthew D Mazalouskas, Hope Pan, Kendra H Oliver, Digna R Velez Edwards, James S Sutcliffe, Joshua C Denny, Ana M D Carneiro