日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Update on mGlu4 modulator patents: 2017 to present

mGlu4调节剂专利最新进展:2017年至今

Rahman, Fahad Imtiaz; Webster, Thomas M; Hopkins, Corey R

End-to-End Backbone Cyclization Enhances Passive Permeability of bRo5 Oligomeric Depsipeptides with Nonlinear Size Dependence

端到端主链环化增强了具有非线性尺寸依赖性的bRo5寡聚缩肽的被动渗透性

Thorpe, Madelaine P; Hopkins, Corey R; Johnston, Jeffrey N

Discovery of VU0467319: an M(1) Positive Allosteric Modulator Candidate That Advanced into Clinical Trials

VU0467319 的发现:一种进入临床试验的 M(1) 正向变构调节剂候选药物

Poslunsey, Michael S; Wood, Michael R; Han, Changho; Stauffer, Shaun R; Panarese, Joseph D; Melancon, Bruce J; Engers, Julie L; Dickerson, Jonathan W; Peng, Weimin; Noetzel, Meredith J; Cho, Hyekyung P; Rodriguez, Alice L; Hopkins, Corey R; Morrison, Ryan; Crouch, Rachel D; Bridges, Thomas M; Blobaum, Anna L; Boutaud, Olivier; Daniels, J Scott; Kates, Michael J; Castelhano, Arlindo; Rook, Jerri M; Niswender, Colleen M; Jones, Carrie K; Conn, P Jeffrey; Lindsley, Craig W

Synthesis and Biological Characterization of 4,4-Difluoro-3-(phenoxymethyl)piperidine Scaffold as Dopamine 4 Receptor (D(4)R) Antagonist in vitro Tool compounds

4,4-二氟-3-(苯氧甲基)哌啶骨架作为多巴胺4受体(D(4)R)体外拮抗剂的合成及生物学表征 工具化合物

Saeedi, Saeedeh; Nahid, Sumaiya; Vadukoot, Anish K; Hopkins, Corey R

Further Structure-Activity Relationship of G Protein-Gated Inwardly Rectifying Potassium Channels 1/2 Activators: Synthesis and Biological Characterization of In Vitro Tool Compounds

G蛋白门控内向整流钾通道1/2激活剂的进一步构效关系研究:体外工具化合物的合成与生物学表征

Nahid, Sumaiya; Rahman, Fahad Imtiaz; Du, Yu; Spitznagel, Brittany D; Singh, Sandeep K; Chhonker, Yashpal S; Murry, Daryl J; Weaver, C David; Hopkins, Corey R

The backbone constitution drives passive permeability independent of side chains in depsipeptide and peptide macrocycles inspired by ent-verticilide

受ent-verticilide启发,缩肽和肽大环化合物的骨架结构驱动了与侧链无关的被动渗透性,这种渗透性在缩肽和肽大环化合物中均有体现。

Thorpe, Madelaine P; Smith, Abigail N; Blackwell, Daniel J; Hopkins, Corey R; Knollmann, Bjorn C; Akers, Wendell S; Johnston, Jeffrey N

In Vivo Pharmacokinetic and Pharmacodynamic Properties of the Antiarrhythmic Molecule ent-Verticilide

抗心律失常分子ent-维替西利德的体内药代动力学和药效学特性

Blackwell, Daniel J; Smith, Abigail N; Do, Tri; Gochman, Aaron; Schmeckpeper, Jeffrey; Hopkins, Corey R; Akers, Wendell S; Johnston, Jeffrey N; Knollmann, Bjorn C

Discovery, synthesis and biological evaluation of a series of N-(phenylcarbamothioyl)-2-napthamides as inhibitors of Claudin-1

发现、合成并评价一系列N-(苯基氨基硫代甲酰基)-2-萘酰胺类化合物作为Claudin-1抑制剂的生物学特性

Mashinson, Viktoriya; Webster, Thomas M; Vadukoot, Anish K; Tolentino, Kirsten T; Simeon, Princess; Fatima, Iram; Dhawan, Punita; Hopkins, Corey R

From dopamine 4 to sigma 1: Synthesis, SAR and biological characterization of a piperidine scaffold of σ1 modulators

从多巴胺 4 到 σ1:哌啶骨架 σ1 调节剂的合成、构效关系和生物学表征

Tolentino, Kirsten T; Mashinson, Viktoriya; Sharma, Manish K; Chhonker, Yashpal S; Murry, Daryl J; Hopkins, Corey R

Structure-Activity Relationships for the N-Me- Versus N-H-Amide Modification to Macrocyclic ent-Verticilide Antiarrhythmics

大环ent-维替西利德抗心律失常药物的N-甲基-与NH-酰胺修饰的构效关系

Smith, Abigail N; Thorpe, Madelaine P; Blackwell, Daniel J; Batiste, Suzanne M; Hopkins, Corey R; Schley, Nathan D; Knollmann, Bjorn C; Johnston, Jeffrey N