日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Engineered coagulation factor VIII with enhanced secretion and coagulation potential for hemophilia A gene therapy

用于血友病A基因治疗的具有增强分泌和凝血潜能的工程化凝血因子VIII

Kashiwakura, Yuji; Nakajima, Yuto; Horinaka, Kio; Lopes, Tiago J S; Furuta, Yuma; Yamaguchi, Yuki; Baatartsogt, Nemekhbayar; Hayakawa, Morisada; Katakai, Yuko; Uchiyama, Susumu; Nureki, Osamu; Nogami, Keiji; Ohmori, Tsukasa

Engineering a compact high-fidelity Staphylococcus aureus Cas9 variant with broader targeting range and mechanistic insights into its activation

构建一种结构紧凑、高保真度的金黄色葡萄球菌Cas9变体,使其具有更广泛的靶向范围,并深入了解其激活机制。

Omura, Satoshi N; Nakagawa, Ryoya; Kajimoto, Shohei; Okazaki, Sae; Ishiguro, Soh; Mori, Hideto; Onishi, Kosuke; Kashiwakura, Yuji; Hiramoto, Takafumi; Horinaka, Kio; Tanaka, Mamoru; Hirano, Hisato; Jividen, Kasey; Yamashita, Keitaro; Tsai, Shengdar Q; Yachie, Nozomu; Ohmori, Tsukasa; Nishimasu, Hiroshi; Nureki, Osamu

AXL-SHC1 signaling axis mediates adaptive resistance to HER2-targeted tyrosine kinase inhibitors in HER2-aberrant lung and gastric cancers

AXL-SHC1信号轴介导HER2异常肺癌和胃癌对HER2靶向酪氨酸激酶抑制剂的适应性耐药

Ishida, Masaki; Yamada, Tadaaki; Katayama, Yuki; Kawachi, Hayato; Sawada, Ryo; Nakamura, Ryota; Hirai, Soichi; Matsui, Yohei; Morimoto, Kenji; Onoi, Keisuke; Nakamura-Sasada, Aosa; Horinaka, Mano; Sakai, Toshiyuki; Sakakida, Tomoki; Doi, Toshifumi; Yasumoto, Kazuo; Goto, Yasuhiro; Furuya, Naoki; Taniguchi, Hirokazu; Ogino, Hirokazu; Takayuki, Nakano; Chihara, Yusuke; Fukuda, Koji; Taniguchi, Hiroaki; Uehara, Hisanori; Yano, Seiji; Tokuda, Shinsaku; Takayama, Koichi

Usefulness of Blood Flow Measurement Device Using Bioelectrical Impedance Plethysmography in Lower-Extremity Artery Disease

生物电阻抗容积描记法血流测量装置在下肢动脉疾病中的应用价值

Horinaka, Shigeo; Sakuma, Masashi; Yonezawa, Yutaka; Watahiki, Manami; Higano, Chika; Toyoda, Shigeru; Yamamoto, Tomoyuki

Association Between Cardio-Ankle Vascular Index and Heart Failure Outcomes: Insights From a Prospective Multicenter Cohort

心踝血管指数与心力衰竭预后之间的关联:一项前瞻性多中心队列研究的启示

Miyoshi, Toru; Shirai, Kohji; Horinaka, Shigeo; Higaki, Jitsuo; Yamamura, Shigeo; Saiki, Atsuhito; Takahashi, Mao; Okura, Takafumi; Kotani, Kazuhiko; Kubozono, Takuro; Yoshioka, Ryo; Kihara, Hajime; Hasegawa, Koji; Satoh-Asahara, Noriko; Yamaguchi, Osamu; Ito, Hiroshi

Epithelial-mesenchymal transition status is a remarkable biomarker for the combination treatment with avutometinib and defactinib in KRAS-mutated non-small cell lung cancer.

上皮间质转化状态是KRAS突变型非小细胞肺癌中avutometinib和defactinib联合治疗的一个显著生物标志物

Yoshimura Akihiro, Horinaka Mano, Yaoi Takeshi, Ono Hisako, Itoh Kyoko, Yamada Tadaaki, Takayama Koichi, Sakai Toshiyuki

Effects of Combined Therapeutic Targeting of AXL and ATR on Pleural Mesothelioma Cells.

联合靶向 AXL 和 ATR 对胸膜间皮瘤细胞的影响

Hirai Soichi, Yamada Tadaaki, Katayama Yuki, Ishida Masaki, Kawachi Hayato, Matsui Yohei, Nakamura Ryota, Morimoto Kenji, Horinaka Mano, Sakai Toshiyuki, Sekido Yoshitaka, Tokuda Shinsaku, Takayama Koichi

Initial AXL and MCL-1 inhibition contributes to abolishing lazertinib tolerance in EGFR-mutant lung cancer cells

初始 AXL 和 MCL-1 抑制有助于消除 EGFR 突变肺癌细胞对拉泽替尼的耐受性

Yohei Matsui, Tadaaki Yamada, Yuki Katayama, Soichi Hirai, Ryo Sawada, Yusuke Tachibana, Masaki Ishida, Hayato Kawachi, Ryota Nakamura, Naoya Nishioka, Kenji Morimoto, Masahiro Iwasaku, Mano Horinaka, Toshiyuki Sakai, Shinsaku Tokuda, Koichi Takayama

Retrospective Longitudinal Observational Study on the Long-Term Effects of Sodium-Glucose Cotransporter-2 Inhibitors on the Development of Metabolic Dysfunction-Associated Steatotic Liver Disease in Type 2 Diabetic Japanese Patients

回顾性纵向观察研究:钠-葡萄糖协同转运蛋白-2抑制剂对2型糖尿病日本患者代谢功能障碍相关脂肪肝疾病发展的影响

Katsuyama, Hisayuki; Horinaka, Seiichi; Hakoshima, Mariko; Adachi, Hiroki; Yanai, Hidekatsu

The Novel HDAC Inhibitor OBP-801 Promotes MHC Class I Presentation Through LMP2 Upregulation, Enhancing the PD-1-Targeting Therapy in Clear Cell Renal Cell Carcinoma

新型 HDAC 抑制剂 OBP-801 通过上调 LMP2 促进 MHC I 类呈递,增强透明细胞肾细胞癌的 PD-1 靶向治疗

Tsukasa Narukawa, Shusuke Yasuda, Mano Horinaka, Keiko Taniguchi, Takahiro Tsujikawa, Mie Morita, Osamu Ukimura, Toshiyuki Sakai