Horton J D相关文献与解析，生知库 | 链接生命科学的每一步

SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation.

SREBP 裂解激活蛋白 (SCAP) 是胆固醇缺乏和胰岛素升高引起的肝脏脂质合成增加所必需的

期刊:Genes & Development

影响因子:7.7

doi:10.1101/gad.891301

Matsuda M, Korn B S, Hammer R E, Moon Y A, Komuro R, Horton J D, Goldstein J L, Brown M S, Shimomura I

免疫/内分泌

发表日期：2001

文献求助收藏

Disruption of LDL receptor gene in transgenic SREBP-1a mice unmasks hyperlipidemia resulting from production of lipid-rich VLDL

转基因SREBP-1a小鼠中LDL受体基因的破坏会揭示由富含脂质的VLDL生成引起的血脂异常。

期刊:Journal of Clinical Investigation

影响因子:13.6

doi:10.1172/JCI6246

Horton, J D; Shimano, H; Hamilton, R L; Brown, M S; Goldstein, J L

Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes

胰岛素选择性地增加链脲佐菌素诱导糖尿病大鼠肝脏中SREBP-1c mRNA的表达。

期刊:Proceedings of the National Academy of Sciences of the United States of America

影响因子:9.1

doi:10.1073/pnas.96.24.13656

Shimomura, I; Bashmakov, Y; Ikemoto, S; Horton, J D; Brown, M S; Goldstein, J L

Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2

在过量表达甾醇调节元件结合蛋白-2的转基因小鼠的肝脏和脂肪组织中，胆固醇合成优先于脂肪酸合成被激活。

期刊:Journal of Clinical Investigation

影响因子:13.6

doi:10.1172/JCI2961

Horton, J D; Shimomura, I; Brown, M S; Hammer, R E; Goldstein, J L; Shimano, H

代谢

发表日期：1998

文献求助收藏

Blunted feedback suppression of SREBP processing by dietary cholesterol in transgenic mice expressing sterol-resistant SCAP(D443N)

转基因小鼠表达抗甾醇SCAP(D443N)后，膳食胆固醇对SREBP加工的反馈抑制作用减弱

期刊:Journal of Clinical Investigation

影响因子:13.6

doi:10.1172/JCI5341

Korn, B S; Shimomura, I; Bashmakov, Y; Hammer, R E; Horton, J D; Goldstein, J L; Brown, M S

Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice

禁食和再喂食小鼠肝脏中甾醇调节元件结合蛋白的调控

期刊:Proceedings of the National Academy of Sciences of the United States of America

影响因子:9.1

doi:10.1073/pnas.95.11.5987

Horton, J D; Bashmakov, Y; Shimomura, I; Shimano, H

信号转导

发表日期：1998

文献求助收藏

Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells

在转基因小鼠肝脏和培养细胞中，甾醇调节元件结合蛋白的异构体1c活性低于异构体1a。

期刊:Journal of Clinical Investigation

影响因子:13.6

doi:10.1172/JCI119248

Shimano, H; Horton, J D; Shimomura, I; Hammer, R E; Brown, M S; Goldstein, J L

细胞生物学

发表日期：1997

文献求助收藏

Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells

在人和小鼠的器官和培养细胞中，甾醇调节元件结合蛋白-1 mRNA 的外显子 1a 和 1c 存在差异表达。

期刊:Journal of Clinical Investigation

影响因子:13.6

doi:10.1172/JCI119247

Shimomura, I; Shimano, H; Horton, J D; Goldstein, J L; Brown, M S

细胞生物学

发表日期：1997

文献求助收藏

Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene

在SREBP-1基因靶向破坏的纯合子小鼠肝脏中，SREBP-2水平升高，胆固醇合成增加。

期刊:Journal of Clinical Investigation

影响因子:13.6

doi:10.1172/JCI119746

Shimano, H; Shimomura, I; Hammer, R E; Herz, J; Goldstein, J L; Brown, M S; Horton, J D

Decreased lipid synthesis in livers of mice with disrupted Site-1 protease gene.

Site-1蛋白酶基因缺失的小鼠肝脏中脂质合成减少

SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation.

SREBP 裂解激活蛋白 (SCAP) 是胆固醇缺乏和胰岛素升高引起的肝脏脂质合成增加所必需的

Disruption of LDL receptor gene in transgenic SREBP-1a mice unmasks hyperlipidemia resulting from production of lipid-rich VLDL

转基因SREBP-1a小鼠中LDL受体基因的破坏会揭示由富含脂质的VLDL生成引起的血脂异常。

Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes

胰岛素选择性地增加链脲佐菌素诱导糖尿病大鼠肝脏中SREBP-1c mRNA的表达。

Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2

在过量表达甾醇调节元件结合蛋白-2的转基因小鼠的肝脏和脂肪组织中，胆固醇合成优先于脂肪酸合成被激活。

Blunted feedback suppression of SREBP processing by dietary cholesterol in transgenic mice expressing sterol-resistant SCAP(D443N)

转基因小鼠表达抗甾醇SCAP(D443N)后，膳食胆固醇对SREBP加工的反馈抑制作用减弱

Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice

禁食和再喂食小鼠肝脏中甾醇调节元件结合蛋白的调控

Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells

在转基因小鼠肝脏和培养细胞中，甾醇调节元件结合蛋白的异构体1c活性低于异构体1a。

Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells

在人和小鼠的器官和培养细胞中，甾醇调节元件结合蛋白-1 mRNA 的外显子 1a 和 1c 存在差异表达。

Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene

在SREBP-1基因靶向破坏的纯合子小鼠肝脏中，SREBP-2水平升高，胆固醇合成增加。