Hosios相关文献与解析，生知库 | 链接生命科学的每一步

Jung-Kuei Chen, Karl A Merrick, Yi Wen Kong, Anita Izrael-Tomasevic, George Eng, Erika D Handly, Jesse C Patterson, Ian G Cannell, Lucia Suarez-Lopez, Aaron M Hosios, Anh Dinh, Donald S Kirkpatrick, Kebing Yu, Christopher M Rose, Jonathan M Hernandez, Haeun Hwangbo, Adam C Palmer, Matthew G Vander H

肿瘤

肠癌

Human

H2AX

发表日期：2024

文献求助收藏

An RNA Damage Response Network Mediates the Lethality of 5-FU in Clinically Relevant Tumor Types

RNA 损伤反应网络介导 5-FU 在临床相关肿瘤类型中的致死率

期刊:

影响因子:

doi:10.1101/2023.04.28.538590

Cancer cells depend on environmental lipids for proliferation when electron acceptors are limited

当电子受体有限时，癌细胞依赖环境脂质进行增殖

期刊:Nature Metabolism

影响因子:18.9

doi:10.1038/s42255-022-00588-8

Zhaoqi Li #, Brian W Ji #, Purushottam D Dixit #, Konstantine Tchourine, Evan C Lien, Aaron M Hosios, Keene L Abbott, Justine C Rutter, Anna M Westermark, Elizabeth F Gorodetsky, Lucas B Sullivan, Matthew G Vander Heiden, Dennis Vitkup

mTORC1 regulates a lysosome-dependent adaptive shift in intracellular lipid species

mTORC1 调节细胞内脂质物种溶酶体依赖性适应性转变

期刊:Nature Metabolism

影响因子:18.9

doi:10.1038/s42255-022-00706-6

Aaron M Hosios, Meghan E Wilkinson, Molly C McNamara, Krystle C Kalafut, Margaret E Torrence, John M Asara, Brendan D Manning

The non-essential TSC complex component TBC1D7 restricts tissue mTORC1 signaling and brain and neuron growth

非必需的 TSC 复合物成分 TBC1D7 会限制组织 mTORC1 信号传导以及大脑和神经元的生长

期刊:Cell Reports

影响因子:7.5

doi:10.1016/j.celrep.2022.110824

Sandra Schrötter, Christopher J Yuskaitis, Michael R MacArthur, Sarah J Mitchell, Aaron M Hosios, Maria Osipovich, Margaret E Torrence, James R Mitchell, Gerta Hoxhaj, Mustafa Sahin, Brendan D Manning

Reciprocal effects of mTOR inhibitors on pro-survival proteins dictate therapeutic responses in tuberous sclerosis complex

mTOR抑制剂对促生存蛋白的相互影响决定了结节性硬化症的治疗反应。

期刊:iScience

影响因子:4.6

doi:10.1016/j.isci.2022.105458

Molly C McNamara ,Aaron M Hosios ,Margaret E Torrence ,Ting Zhao ,Cameron Fraser ,Meghan Wilkinson ,David J Kwiatkowski ,Elizabeth P Henske ,Chin-Lee Wu ,Kristopher A Sarosiek ,Alexander J Valvezan ,Brendan D Manning

mTOR

发表日期：2022

文献求助收藏

The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals

mTORC1 介导的 ATF4 激活促进生长信号下游的蛋白质和谷胱甘肽合成

期刊:Elife

影响因子:6.4

doi:10.7554/eLife.63326

Margaret E Torrence, Michael R MacArthur, Aaron M Hosios, Alexander J Valvezan, John M Asara, James R Mitchell, Brendan D Manning

Differential substrate use in EGF- and oncogenic KRAS-stimulated human mammary epithelial cells

EGF 和致癌 KRAS 刺激的人类乳腺上皮细胞中的差异底物使用

期刊:FEBS Journal

影响因子:5.5

doi:10.1111/febs.15858

Mark A Keibler, Wentao Dong, Keegan D Korthauer, Aaron M Hosios, Sun Jin Moon, Lucas B Sullivan, Nian Liu, Keene L Abbott, Orlando D Arevalo, Kailing Ho, Jennifer Lee, Aasavari S Phanse, Joanne K Kelleher, Othon Iliopoulos, Jonathan L Coloff, Matthew G Vander Heiden, Gregory Stephanopoulos

Cancer-associated mutations in human pyruvate kinase M2 impair enzyme activity

人类丙酮酸激酶 M2 的癌症相关突变会损害酶活性

期刊:FEBS Letters

影响因子:3

doi:10.1002/1873-3468.13648

Vivian M Liu, Andrea J Howell, Aaron M Hosios, Zhaoqi Li, William J Israelsen, Matthew G Vander Heiden

Reactive metabolite production is a targetable liability of glycolytic metabolism in lung cancer

反应性代谢物的产生是肺癌糖酵解代谢的一个可靶向的负担

期刊:Nature Communications

影响因子:14.7

doi:10.1038/s41467-019-13419-4

Alba Luengo, Keene L Abbott, Shawn M Davidson, Aaron M Hosios, Brandon Faubert, Sze Ham Chan, Elizaveta Freinkman, Lauren G Zacharias, Thomas P Mathews, Clary B Clish, Ralph J DeBerardinis, Caroline A Lewis, Matthew G Vander Heiden

An RNA damage response network mediates the lethality of 5-FU in colorectal cancer

RNA 损伤反应网络介导 5-FU 在结直肠癌中的致死率

An RNA Damage Response Network Mediates the Lethality of 5-FU in Clinically Relevant Tumor Types

RNA 损伤反应网络介导 5-FU 在临床相关肿瘤类型中的致死率

Cancer cells depend on environmental lipids for proliferation when electron acceptors are limited

当电子受体有限时，癌细胞依赖环境脂质进行增殖

mTORC1 regulates a lysosome-dependent adaptive shift in intracellular lipid species

mTORC1 调节细胞内脂质物种溶酶体依赖性适应性转变

The non-essential TSC complex component TBC1D7 restricts tissue mTORC1 signaling and brain and neuron growth

非必需的 TSC 复合物成分 TBC1D7 会限制组织 mTORC1 信号传导以及大脑和神经元的生长

Reciprocal effects of mTOR inhibitors on pro-survival proteins dictate therapeutic responses in tuberous sclerosis complex

mTOR抑制剂对促生存蛋白的相互影响决定了结节性硬化症的治疗反应。

The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals

mTORC1 介导的 ATF4 激活促进生长信号下游的蛋白质和谷胱甘肽合成

Differential substrate use in EGF- and oncogenic KRAS-stimulated human mammary epithelial cells

EGF 和致癌 KRAS 刺激的人类乳腺上皮细胞中的差异底物使用

Cancer-associated mutations in human pyruvate kinase M2 impair enzyme activity

人类丙酮酸激酶 M2 的癌症相关突变会损害酶活性

Reactive metabolite production is a targetable liability of glycolytic metabolism in lung cancer

反应性代谢物的产生是肺癌糖酵解代谢的一个可靶向的负担