日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Development of Fc-Fused Cocaine Hydrolase for Cocaine Addiction Treatment: Catalytic and Pharmacokinetic Properties

用于可卡因成瘾治疗的 Fc 融合可卡因水解酶的开发:催化和药代动力学特性

Xiabin Chen, Jing Deng, Wenpeng Cui, Shurong Hou, Jinling Zhang, Xirong Zheng, Xin Ding, Huimei Wei, Ziyuan Zhou, Kyungbo Kim, Chang-Guo Zhan, Fang Zheng

Erythropoietin employs cell longevity pathways of SIRT1 to foster endothelial vascular integrity during oxidant stress.

红细胞生成素利用 SIRT1 的细胞寿命通路在氧化应激期间促进内皮血管完整性

Hou Jinling, Wang Shaohui, Shang Yan Chen, Chong Zhao Zhong, Maiese Kenneth

EPO relies upon novel signaling of Wnt1 that requires Akt1, FoxO3a, GSK-3β, and β-catenin to foster vascular integrity during experimental diabetes.

EPO 依赖于 Wnt1 的新型信号传导,该信号传导需要 Akt1、FoxO3a、GSK-3β 和 β-catenin 来促进实验性糖尿病期间的血管完整性

Chong Zhao Zhong, Hou Jinling, Shang Yan Chen, Wang Shaohui, Maiese Kenneth

Oxidative stress: Biomarkers and novel therapeutic pathways

氧化应激:生物标志物和新型治疗途径

Maiese, Kenneth; Chong, Zhao Zhong; Hou, Jinling; Shang, Yan Chen

Wnt1, FoxO3a, and NF-kappaB oversee microglial integrity and activation during oxidant stress.

Wnt1、FoxO3a 和 NF-kappaB 在氧化应激期间负责小胶质细胞的完整性和激活

Shang Yan Chen, Chong Zhao Zhong, Hou Jinling, Maiese Kenneth

FOXO3a governs early and late apoptotic endothelial programs during elevated glucose through mitochondrial and caspase signaling.

FOXO3a 通过线粒体和 caspase 信号传导,在高血糖期间控制内皮细胞的早期和晚期凋亡程序

Hou Jinling, Chong Zhao Zhong, Shang Yan Chen, Maiese Kenneth

Diabetes mellitus: channeling care through cellular discovery

糖尿病:通过细胞发现引导治疗

Maiese, Kenneth; Shang, Yan Chen; Chong, Zhao Zhong; Hou, Jinling

Early apoptotic vascular signaling is determined by Sirt1 through nuclear shuttling, forkhead trafficking, bad, and mitochondrial caspase activation.

早期凋亡血管信号传导由 Sirt1 通过核穿梭、叉头运输、坏死因子和线粒体半胱天冬酶激活来决定

Hou Jinling, Chong Zhao Zhong, Shang Yan Chen, Maiese Kenneth

Wnt1 neuroprotection translates into improved neurological function during oxidant stress and cerebral ischemia through AKT1 and mitochondrial apoptotic pathways.

Wnt1 神经保护作用通过 AKT1 和线粒体凋亡途径,在氧化应激和脑缺血期间改善神经功能

Chong Zhao Zhong, Shang Yan Chen, Hou Jinling, Maiese Kenneth

The forkhead transcription factor FOXO3a controls microglial inflammatory activation and eventual apoptotic injury through caspase 3.

叉头转录因子 FOXO3a 通过 caspase 3 控制小胶质细胞的炎症激活和最终的细胞凋亡损伤

Shang Yan Chen, Chong Zhao Zhong, Hou Jinling, Maiese Kenneth