日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

One-Carbon Metabolism Inhibition Depletes Purines and Results in Profound and Prolonged Ewing Sarcoma Growth Suppression

一碳代谢抑制会消耗嘌呤,从而导致尤文氏肉瘤生长受到显著且持久的抑制。

Zirpoli, Sara; Copperman, Noah; Patel, Shrey; Forrest, Alexander; Hou, Zhanjun; Matherly, Larry H; Loeb, David M; Di Cristofano, Antonio

Determination of the pyrrolo[2,3-d] pyrimidine antifolate AGF94 from a preclinical murine study using a simple UHPLC-MS/MS assay

利用简便的超高效液相色谱-串联质谱法(UHPLC-MS/MS)测定临床前小鼠研究中的吡咯并[2,3-d]嘧啶类抗叶酸AGF94。

Metz, Tryston T; Ashe, Rachel C; Duncan, Alexis C; Wilner, Ethan C; Schmidt, Keith T; Gudmundsson, Kristbjorn O; Hou, Zhanjun; Gangjee, Aleem; Matherly, Larry H; Kozlov, Serguei V; Figg, William D

Inhibition Of One-Carbon Metabolism In Ewing Sarcoma Results In Profound And Prolonged Growth Suppression Associated With Purine Depletion

抑制尤文氏肉瘤中的一碳代谢会导致嘌呤耗竭,从而造成显著且持久的生长抑制。

Zirpoli, Sara; Copperman, Noah; Patel, Shrey; Forrest, Alexander; Hou, Zhanjun; Matherly, Larry H; Loeb, David M; Di Cristofano, Antonio

Enhancing anti-AML activity of venetoclax by isoflavone ME-344 through suppression of OXPHOS and/or purine biosynthesis in vitro

异黄酮ME-344通过抑制体外氧化磷酸化和/或嘌呤生物合成增强维奈托克的抗急性髓系白血病活性

Hurrish, Katie H; Su, Yongwei; Patel, Shraddha; Ramage, Cassandra L; Zhao, Jianlei; Temby, Brianna R; Carter, Jenna L; Edwards, Holly; Buck, Steven A; Wiley, Sandra E; Hüttemann, Maik; Polin, Lisa; Kushner, Juiwanna; Dzinic, Sijana H; White, Kathryn; Bao, Xun; Li, Jing; Yang, Jay; Boerner, Julie; Hou, Zhanjun; Al-Atrash, Gheath; Konoplev, Sergej N; Busquets, Jonathan; Tiziani, Stefano; Matherly, Larry H; Taub, Jeffrey W; Konopleva, Marina; Ge, Yubin; Baran, Natalia

BRCA Status Dictates Wnt Responsiveness in Epithelial Ovarian Cancer.

BRCA 状态决定上皮性卵巢癌对 Wnt 信号通路的反应性

Chehade Hussein, Gogoi Radhika, Adzibolosu Nicholas K, Galoforo Sandra, Fehmi Rouba-Ali, Kheil Mira, Fox Alexandra, Kim Seongho, Rattan Ramandeep, Hou Zhanjun, Morris Robert T, Matherly Larry H, Mor Gil, Alvero Ayesha B

Role of Mitochondrial and Cytosolic Folylpolyglutamate Synthetase in One-Carbon Metabolism and Antitumor Efficacy of Mitochondrial-Targeted Antifolates

线粒体和胞质叶酸多聚谷氨酸合成酶在单碳代谢中的作用及线粒体靶向抗叶酸药物的抗肿瘤疗效

O'Connor, Carrie; Schneider, Mathew; Katinas, Jade M; Nayeen, Md Junayed; Shah, Khushbu; Magdum, Tejashree; Sharma, Abhishekh; Kim, Seongho; Bao, Xun; Li, Jing; Dann, Charles E; Gangjee, Aleem; Matherly, Larry H; Hou, Zhanjun

Structural Characterization of 5-Substituted Pyrrolo[3,2-d]pyrimidine Antifolate Inhibitors in Complex with Human Serine Hydroxymethyl Transferase 2

5-取代吡咯并[3,2-d]嘧啶类抗叶酸抑制剂与人丝氨酸羟甲基转移酶2复合物的结构表征

Katinas, Jade M; Nayeen, Md Junayed; Schneider, Mathew; Shah, Khushbu; Fifer, Alexandra N; Klapper, Lily M; Sharma, Abhishekh; Thalluri, Kishore; Van Nieuwenhze, Michael S; Hou, Zhanjun; Gangjee, Aleem; Matherly, Larry H; Dann, Charles E 3rd

Biology and therapeutic applications of the proton-coupled folate transporter

质子偶联叶酸转运体的生物学和治疗应用

Matherly, Larry H; Schneider, Mathew; Gangjee, Aleem; Hou, Zhanjun

Folate Transport and One-Carbon Metabolism in Targeted Therapies of Epithelial Ovarian Cancer

叶酸转运和一碳代谢在卵巢上皮癌靶向治疗中的作用

Wallace-Povirk, Adrianne; Hou, Zhanjun; Nayeen, Md Junayed; Gangjee, Aleem; Matherly, Larry H

Therapeutic Targeting of Mitochondrial One-Carbon Metabolism in Cancer

癌症中线粒体一碳代谢的治疗靶点

Dekhne, Aamod S; Hou, Zhanjun; Gangjee, Aleem; Matherly, Larry H