日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Development of clinically viable non-muscle myosin II small molecule inhibitors.

开发具有临床应用价值的非肌肉肌球蛋白 II 小分子抑制剂

Radnai Laszlo, Young Erica J, Kikuti Carlos, Toth Katalin, Zhou Minghai, Hafenbreidel Madalyn, Stremel Rebecca F, Lin Li, Pasetto Paolo, Jin Xiaomin, Patel Aagam, Conlon Michael, Briggs Sherri B, Heidsieck Leïla, Sweeney H Lee, Sellers James, Krieger-Burke Teresa, Martin William H, Sisco Jay, Young Steven, Pearson Paul, Rumbaugh Gavin, Araldi Gian Luca, Duddy Steven K, Cameron Michael D, Surman Matthew, Houdusse Anne, Griffin Patrick R, Kamenecka Theodore M, Miller Courtney A

Hypertrophic cardiomyopathy mutations Y115H and E497D disrupt the folded-back state of human β-cardiac myosin allosterically

肥厚型心肌病突变Y115H和E497D通过变构作用破坏人β-心肌肌球蛋白的折叠状态。

Nandwani, Neha; Bhowmik, Debanjan; Glaser, Camille; Childers, Matthew Carter; Goluguri, Rama Reddy; Dawood, Aminah; Regnier, Michael; Houdusse, Anne; Spudich, James A; Ruppel, Kathleen M

Coupling between the lever arm and active site via an N-terminal extension tunes force sensitivity in the myosin-1 family

肌球蛋白-1家族中,杠杆臂与活性位点之间通过N端延伸的耦合作用调节力敏感性。

Rathbone, Harry W; Houdusse, Anne

Modulation of Filopodial Myosin Function.

丝状伪足肌球蛋白功能的调节

Crawford Amy, Schwartz Jessica K, Hall Emerson, Houdusse Anne, Titus Margaret A

Aficamten is a small-molecule cardiac myosin inhibitor designed to treat hypertrophic cardiomyopathy

Aficamten是一种小分子心肌肌球蛋白抑制剂,旨在治疗肥厚型心肌病。

Hartman, James J; Hwee, Darren T; Robert-Paganin, Julien; Chuang, Chihyuan; Chin, Eva R; Edell, Samantha; Lee, Ken H; Madhvani, Roshni; Paliwal, Preeti; Pernier, Julien; Sarkar, Saswata Sankar; Schaletzky, Julia; Schauer, Kristine; Taheri, Khanha D; Wang, Jingying; Wehri, Eddie; Wu, Yangsong; Houdusse, Anne; Morgan, Bradley P; Malik, Fady I

Reassessing the unifying hypothesis for hypercontractility caused by myosin mutations in hypertrophic cardiomyopathy

重新评估肥厚型心肌病中肌球蛋白突变引起的过度收缩的统一假说

Spudich, James A; Nandwani, Neha; Robert-Paganin, Julien; Houdusse, Anne; Ruppel, Kathleen M

Uncovering the Relationship Between Genes and Phenotypes Beyond the Gut in Microvillus Inclusion Disease

揭示微绒毛包涵体病中肠道以外的基因与表型之间的关系

Sun, Mingyue; Pylypenko, Olena; Zhou, Zhe; Xu, Mingqian; Li, Qinghong; Houdusse, Anne; van IJzendoorn, Sven C D

A weak coupling mechanism for the early steps of the recovery stroke of myosin VI: A free energy simulation and string method analysis

肌球蛋白VI恢复冲程早期步骤的弱耦合机制:自由能模拟和弦方法分析

Blanc, Florian E C; Houdusse, Anne; Cecchini, Marco

Development of Clinically Viable Non-Muscle Myosin II Small Molecule Inhibitors with Broad Therapeutic Potential

开发具有广泛治疗潜力的临床可行的非肌肉肌球蛋白II小分子抑制剂

Radnai, Laszlo; Young, Erica J; Kikuti, Carlos; Hafenbreidel, Madalyn; Stremel, Rebecca F; Lin, Li; Toth, Katalin; Pasetto, Paolo; Jin, Xiaomin; Patel, Aagam; Conlon, Michael; Briggs, Sherri; Heidsieck, Leïla; Sweeney, H Lee; Sellers, James; Krieger-Burke, Teresa; Martin, William H; Sisco, Jay; Young, Steven; Pearson, Paul; Rumbaugh, Gavin; Araldi, Gian Luca; Duddy, Steven K; Cameron, Michael D; Surman, Matthew; Houdusse, Anne; Griffin, Patrick R; Kamenecka, Theodore M; Miller, Courtney A

Nucleotide-free structures of KIF20A illuminate atypical mechanochemistry in this kinesin-6

KIF20A 的无核苷酸结构揭示了这种驱动蛋白-6 中非典型的机械化学性质。

Ranaivoson, Fanomezana Moutse; Crozet, Vincent; Benoit, Matthieu P M H; Abdalla Mohammed Khalid, Amna; Kikuti, Carlos; Sirkia, Helena; El Marjou, Ahmed; Miserey-Lenkei, Stéphanie; Asenjo, Ana B; Sosa, Hernando; Schmidt, Christoph F; Rosenfeld, Steven S; Houdusse, Anne