日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling

一项针对122341名欧洲血统患者的主要焦虑症的全基因组关联研究,发现了58个基因位点,并强调了GABA能信号传导的作用。

Strom, Nora I; Verhulst, Brad; Bacanu, Silviu-Alin; Cheesman, Rosa; Purves, Kirstin L; Gedik, Hüseyin; Mitchell, Brittany L; Kwong, Alex S; Faucon, Annika B; Singh, Kritika; Medland, Sarah; Colodro-Conde, Lucia; Krebs, Kristi; Hoffmann, Per; Herms, Stefan; Gehlen, Jan; Ripke, Stephan; Awasthi, Swapnil; Palviainen, Teemu; Tasanko, Elisa M; Peterson, Roseann E; Adkins, Daniel E; Shabalin, Andrey A; Adams, Mark J; Iveson, Matthew H; Campbell, Archie; Thomas, Laurent F; Winsvold, Bendik S; Drange, Ole Kristian; Børte, Sigrid; Ter Kuile, Abigail R; Naamanka, Joonas; Nguyen, Tan-Hoang; Meier, Sandra M; Corfield, Elizabeth C; Hannigan, Laurie; Levey, Daniel F; Czamara, Darina; Weber, Heike; Choi, Karmel W; Pistis, Giorgio; Couvy-Duchesne, Baptiste; Van der Auwera, Sandra; Teumer, Alexander; Karlsson, Robert; Garcia-Argibay, Miguel; Lee, Donghyung; Wang, Rujia; Bjerkeset, Ottar; Stordal, Eystein; Bäckman, Julia; Salum, Giovanni A; Zai, Clement C; Kennedy, James L; Zai, Gwyneth; Tiwari, Arun K; Heilmann-Heimbach, Stefanie; Schmidt, Börge; Kaprio, Jaakko; Kennedy, Martin M; Boden, Joseph; Havdahl, Alexandra; Middeldorp, Christel M; Lopes, Fabiana L; Akula, Nirmala; McMahon, Francis J; Binder, Elisabeth B; Fehm, Lydia; Ströhle, Andreas; Castelao, Enrique; Tiemeier, Henning; Stein, Dan J; Whiteman, David; Olsen, Catherine; Fuller, Zachary; Wang, Xin; Wray, Naomi R; Byrne, Enda M; Lewis, Glyn; Timpson, Nicholas J; Davis, Lea K; Hickie, Ian B; Gillespie, Nathan A; Milani, Lili; Schumacher, Johannes; Woldbye, David P; Forstner, Andreas J; Nöthen, Markus M; Hovatta, Iiris; Horwood, John; Copeland, William E; Maes, Hermine H; McIntosh, Andrew M; Andreassen, Ole A; Zwart, John-Anker; Mors, Ole; Børglum, Anders D; Mortensen, Preben B; Ask, Helga; Reichborn-Kjennerud, Ted; Najman, Jackob M; Stein, Murray B; Gelernter, Joel; Milaneschi, Yuri; Penninx, Brenda W; Boomsma, Dorret I; Maron, Eduard; Erhardt-Lehmann, Angelika; Rück, Christian; Kircher, Tilo T; Melzig, Christiane A; Alpers, Georg W; Arolt, Volker; Domschke, Katharina; Smoller, Jordan W; Preisig, Martin; Martin, Nicholas G; Lupton, Michelle K; Luik, Annemarie I; Reif, Andreas; Grabe, Hans J; Larsson, Henrik; Magnusson, Patrik K; Oldehinkel, Albertine J; Hartman, Catharina A; Breen, Gerome; Docherty, Anna R; Coon, Hilary; Conrad, Rupert; Lehto, Kelli; Deckert, Jürgen; Eley, Thalia C; Mattheisen, Manuel; Hettema, John M

The Microbiota Shapes Central Nervous System Myelination in Early Life

微生物群在生命早期影响中枢神经系统的髓鞘形成

Lynch, Caoimhe M K; Knox, Emily G; Soong, Daniel; Bastiaanssen, Thomaz F S; Trontti, Kalevi; Tofani, Gabriel S S; Ivaschuk, Sophia; Collins, Michael K; Arafa, Donia; Nagpal, Jatin; Hovatta, Iiris; Lyons, David A; Clarke, Gerard; Cryan, John F

Predicting cardiovascular morbidity and mortality with SCORE2 (OP) and Framingham risk estimates in combination with indicators of biological ageing

结合 SCORE2 (OP) 和 Framingham 风险评估以及生物衰老指标预测心血管疾病发病率和死亡率

Tirkkonen, Anna; Mak, Jonathan K L; Eriksson, Johan G; Halonen, Pauliina; Jylhävä, Juulia; Hägg, Sara; Enroth, Linda; Raitanen, Jani; Hovatta, Iiris; Jääskeläinen, Tuija; Koskinen, Seppo; Haapanen, Markus J; von Bonsdorff, Mikaela B; Kananen, Laura

Distinct Genetic Risk Profile in Aortic Stenosis Compared With Coronary Artery Disease

主动脉瓣狭窄与冠状动脉疾病的遗传风险特征存在显著差异

Trenkwalder, Teresa; Maj, Carlo; Al-Kassou, Baravan; Debiec, Radoslaw; Doppler, Stefanie A; Musameh, Muntaser D; Nelson, Christopher P; Dasmeh, Pouria; Grover, Sandeep; Knoll, Katharina; Naamanka, Joonas; Mordi, Ify R; Braund, Peter S; Dreßen, Martina; Lahm, Harald; Wirth, Felix; Baldus, Stephan; Kelm, Malte; von Scheidt, Moritz; Krefting, Johannes; Ellinghaus, David; Small, Aeron M; Peloso, Gina M; Natarajan, Pradeep; Thanassoulis, George; Engert, James C; Dufresne, Line; Franke, Andre; Görg, Siegfried; Laudes, Matthias; Nowak-Göttl, Ulrike; Vaht, Mariliis; Metspalu, Andres; Stoll, Monika; Berger, Klaus; Pellegrini, Costanza; Kastrati, Adnan; Hengstenberg, Christian; Lang, Chim C; Kessler, Thorsten; Hovatta, Iiris; Nickenig, Georg; Nöthen, Markus M; Krane, Markus; Schunkert, Heribert; Samani, Nilesh J; Schumacher, Johannes; Kals, Mart; Reigo, Anu; Teder-Laving, Maris; Gehlen, Jan; Webb, Thomas R; Giel, Ann-Sophie; Koebbe, Laura L; Feirer, Nina; Billmann, Maximilian; Srinivasan, Sundar; Zimmer, Sebastian; Palmer, Colin N A; Li, Ling; Yang, Chuhua; Borisov, Oleg; Adam, Matti; Veulemans, Verena; Joner, Michael; Xhepa, Erion

Genetic contribution to microglial activation in schizophrenia

遗传因素对精神分裂症小胶质细胞活化的贡献

Marja Koskuvi, Elina Pörsti, Tristen Hewitt, Noora Räsänen, Ying-Chieh Wu, Kalevi Trontti, Amanda McQuade, Shringaa Kalyanaraman, Ilkka Ojansuu, Olli Vaurio, Tyrone D Cannon, Jouko Lönnqvist, Sebastian Therman, Jaana Suvisaari, Jaakko Kaprio, Mathew Blurton-Jones, Iiris Hovatta, Markku Lähteenvuo, T

Human iPSC-derived pericyte-like cells carrying APP Swedish mutation overproduce beta-amyloid and induce cerebral amyloid angiopathy-like changes

携带 APP 瑞典突变的人类 iPSC 衍生的周细胞样细胞会过量产生 β-淀粉样蛋白并诱发脑淀粉样血管病样改变

Ying-Chieh Wu, Šárka Lehtonen, Kalevi Trontti, Riitta Kauppinen, Pinja Kettunen, Ville Leinonen, Markku Laakso, Johanna Kuusisto, Mikko Hiltunen, Iiris Hovatta, Kristine Freude, Hiramani Dhungana, Jari Koistinaho, Taisia Rolova

Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling

一项针对122341名欧洲血统患者的主要焦虑症的全基因组关联研究,发现了58个基因位点,并强调了GABA能信号传导的作用。

Strom, Nora I; Verhulst, Brad; Bacanu, Silviu-Alin; Cheesman, Rosa; Purves, Kirstin L; Gedik, Hüseyin; Mitchell, Brittany L; Kwong, Alex S; Faucon, Annika B; Singh, Kritika; Medland, Sarah; Colodro-Conde, Lucia; Krebs, Kristi; Hoffmann, Per; Herms, Stefan; Gehlen, Jan; Ripke, Stephan; Awasthi, Swapnil; Palviainen, Teemu; Tasanko, Elisa M; Peterson, Roseann E; Adkins, Daniel E; Shabalin, Andrey A; Adams, Mark J; Iveson, Matthew H; Campbell, Archie; Thomas, Laurent F; Winsvold, Bendik S; Drange, Ole Kristian; Børte, Sigrid; Ter Kuile, Abigail R; Nguyen, Tan-Hoang; Meier, Sandra M; Corfield, Elizabeth C; Hannigan, Laurie; Levey, Daniel F; Czamara, Darina; Weber, Heike; Choi, Karmel W; Pistis, Giorgio; Couvy-Duchesne, Baptiste; Van der Auwera, Sandra; Teumer, Alexander; Karlsson, Robert; Garcia-Argibay, Miguel; Lee, Donghyung; Wang, Rujia; Bjerkeset, Ottar; Stordal, Eystein; Bäckmann, Julia; Salum, Giovanni A; Zai, Clement C; Kennedy, James L; Zai, Gwyneth; Tiwari, Arun K; Heilmann-Heimbach, Stefanie; Schmidt, Börge; Kaprio, Jaakko; Kennedy, Martin M; Boden, Joseph; Havdahl, Alexandra; Middeldorp, Christel M; Lopes, Fabiana L; Akula, Nirmala; McMahon, Francis J; Binder, Elisabeth B; Fehm, Lydia; Ströhle, Andreas; Castelao, Enrique; Tiemeier, Henning; Stein, Dan J; Whiteman, David; Olsen, Catherine; Fuller, Zachary; Wang, Xin; Wray, Naomi R; Byrne, Enda M; Lewis, Glyn; Timpson, Nicholas J; Davis, Lea K; Hickie, Ian B; Gillespie, Nathan A; Milani, Lili; Schumacher, Johannes; Woldbye, David P; Forstner, Andreas J; Nöthen, Markus M; Hovatta, Iiris; Horwood, John; Copeland, William E; Maes, Hermine H; McIntosh, Andrew M; Andreassen, Ole A; Zwart, John-Anker; Mors, Ole; Børglum, Anders D; Mortensen, Preben B; Ask, Helga; Reichborn-Kjennerud, Ted; Najman, Jackob M; Stein, Murray B; Gelernter, Joel; Milaneschi, Yuri; Penninx, Brenda W; Boomsma, Dorret I; Maron, Eduard; Erhardt-Lehmann, Angelika; Rück, Christian; Kircher, Tilo T; Melzig, Christiane A; Alpers, Georg W; Arolt, Volker; Domschke, Katharina; Smoller, Jordan W; Preisig, Martin; Martin, Nicholas G; Lupton, Michelle K; Luik, Annemarie I; Reif, Andreas; Grabe, Hans J; Larsson, Henrik; Magnusson, Patrik K; Oldehinkel, Albertine J; Hartman, Catharina A; Breen, Gerome; Docherty, Anna R; Coon, Hilary; Conrad, Rupert; Lehto, Kelli; Deckert, Jürgen; Eley, Thalia C; Mattheisen, Manuel; Hettema, John M

Node of Ranvier remodeling in chronic psychosocial stress and anxiety

慢性社会心理压力和焦虑症中的郎飞氏结重塑

Maija-Kreetta Koskinen #, Mikaela Laine #, Ali Abdollahzadeh, Adrien Gigliotta, Giulia Mazzini, Sarah Journée, Varpu Alenius, Kalevi Trontti, Jussi Tohka, Petri Hyytiä, Alejandra Sierra, Iiris Hovatta

Expression patterns of NKCC1 in neurons and non-neuronal cells during cortico-hippocampal development

皮质海马发育过程中 NKCC1 在神经元和非神经元细胞中的表达模式

Samu N Kurki, Pavel Uvarov, Alexey S Pospelov, Kalevi Trontti, Antje K Hübner, Rakenduvadhana Srinivasan, Masahiko Watanabe, Iiris Hovatta, Christian A Hübner, Kai Kaila, Mari A Virtanen

Gene expression profiling reveals a role of immune system and inflammation in innate and stress-induced anxiety-like behavior

基因表达谱揭示了免疫系统和炎症在先天和压力引起的焦虑样行为中的作用

Adrien Gigliotta, Kalevi Trontti, Juho Väänänen, Iiris Hovatta