日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The Landscape of Early Clinical Gene Therapies outside of Oncology

肿瘤学以外早期临床基因疗法的概况

Rittié, Laure; Athanasopoulos, Takis; Calero-Garcia, Miguel; Davies, Marie L; Dow, David J; Howe, Steven J; Morrison, Alastair; Ricciardelli, Ida; Saudemont, Aurore; Jespers, Laurent; Clay, Timothy M

Inhibition of Mitochondrial Complex I Impairs Release of α-Galactosidase by Jurkat Cells.

抑制线粒体复合物 I 会损害 Jurkat 细胞释放 α-半乳糖苷酶

Lambert Jonathan R A, Howe Steven J, Rahim Ahad A, Burke Derek G, Heales Simon J R

BMI-1 extends proliferative potential of human bronchial epithelial cells while retaining their mucociliary differentiation capacity

BMI-1可延长人支气管上皮细胞的增殖潜能,同时保留其黏液纤毛分化能力。

Munye, Mustafa M; Shoemark, Amelia; Hirst, Robert A; Delhove, Juliette M; Sharp, Tyson V; McKay, Tristan R; O'Callaghan, Christopher; Baines, Deborah L; Howe, Steven J; Hart, Stephen L

Evidence for contribution of CD4+ CD25+ regulatory T cells in maintaining immune tolerance to human factor IX following perinatal adenovirus vector delivery

证据表明,CD4+CD25+调节性T细胞在围产期腺病毒载体递送后维持对人凝血因子IX的免疫耐受中发挥作用

Nivsarkar, Megha S; Buckley, Suzanne M K; Parker, Alan L; Perocheau, Dany; McKay, Tristan R; Rahim, Ahad A; Howe, Steven J; Waddington, Simon N

Hematopoietic stem cell and gene therapy corrects primary neuropathology and behavior in mucopolysaccharidosis IIIA mice

造血干细胞和基因疗法可纠正粘多糖贮积症 IIIA 小鼠的原发性神经病理学和行为异常

Langford-Smith, Alexander; Wilkinson, Fiona L; Langford-Smith, Kia J; Holley, Rebecca J; Sergijenko, Ana; Howe, Steven J; Bennett, William R; Jones, Simon A; Wraith, Je; Merry, Catherine Lr; Wynn, Robert F; Bigger, Brian W

Insertion sites in engrafted cells cluster within a limited repertoire of genomic areas after gammaretroviral vector gene therapy

γ逆转录病毒载体基因治疗后,移植细胞中的插入位点集中在有限的基因组区域内。

Deichmann, Annette; Brugman, Martijn H; Bartholomae, Cynthia C; Schwarzwaelder, Kerstin; Verstegen, Monique M A; Howe, Steven J; Arens, Anne; Ott, Marion G; Hoelzer, Dieter; Seger, Reinhard; Grez, Manuel; Hacein-Bey-Abina, Salima; Cavazzana-Calvo, Marina; Fischer, Alain; Paruzynski, Anna; Gabriel, Richard; Glimm, Hanno; Abel, Ulrich; Cattoglio, Claudia; Mavilio, Fulvio; Cassani, Barbara; Aiuti, Alessandro; Dunbar, Cynthia E; Baum, Christopher; Gaspar, H Bobby; Thrasher, Adrian J; von Kalle, Christof; Schmidt, Manfred; Wagemaker, Gerard

Perinatal gene transfer to the liver

围产期基因转移至肝脏

McKay, Tristan R; Rahim, Ahad A; Buckley, Suzanne M K; Ward, Natalie J; Chan, Jerry K Y; Howe, Steven J; Waddington, Simon N

Tolerance induction using lentiviral gene delivery delays onset and severity of collagen II arthritis.

利用慢病毒基因递送诱导耐受性可延缓 II 型胶原关节炎的发病和严重程度

Gjertsson Inger, Laurie Karen L, Devitt James, Howe Steven J, Thrasher Adrian J, Holmdahl Rikard, Gustafsson Kenth

Vector integration is nonrandom and clustered and influences the fate of lymphopoiesis in SCID-X1 gene therapy

载体整合是非随机的、聚集性的,并影响SCID-X1基因治疗中淋巴细胞生成的命运。

Deichmann, Annette; Hacein-Bey-Abina, Salima; Schmidt, Manfred; Garrigue, Alexandrine; Brugman, Martijn H; Hu, Jingqiong; Glimm, Hanno; Gyapay, Gabor; Prum, Bernard; Fraser, Christopher C; Fischer, Nicolas; Schwarzwaelder, Kerstin; Siegler, Maria-Luise; de Ridder, Dick; Pike-Overzet, Karin; Howe, Steven J; Thrasher, Adrian J; Wagemaker, Gerard; Abel, Ulrich; Staal, Frank J T; Delabesse, Eric; Villeval, Jean-Luc; Aronow, Bruce; Hue, Christophe; Prinz, Claudia; Wissler, Manuela; Klanke, Chuck; Weissenbach, Jean; Alexander, Ian; Fischer, Alain; von Kalle, Christof; Cavazzana-Calvo, Marina