日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Suppression of Huntington's Disease Somatic Instability by Transcriptional Repression and Direct CAG Repeat Binding.

通过转录抑制和直接 CAG 重复序列结合抑制亨廷顿病体细胞不稳定性。

Mathews Ella W, Coffey Sydney R, Gärtner Annette, Belgrad Jillian, Bragg Robert M, O'Reilly Daniel, Cantle Jeffrey P, McHugh Cassandra, Summers Ashley, Fentz Joachim, Schwagarus Tom, Cornelius Antje, Lingos Ioannis, Burch Zoe, Kovalenko Marina, Andrew Marissa A, Bennett C Frank, Kordasiewicz Holly B, Marchionini Deanna M, Wilkinson Hilary, Vogt Thomas F, Beuzer Paolo, Pinto Ricardo M, Khvorova Anastasia, Howland David, Wheeler Vanessa C, Carroll Jeffrey B

Blocking somatic repeat expansion and lowering huntingtin via RNA interference synergize to prevent Huntington's disease pathogenesis in mice

通过RNA干扰抑制体细胞重复序列扩增和降低亨廷顿蛋白水平可协同预防小鼠亨廷顿病的发病机制。

Belgrad, Jillian; Summers, Ashley; Landles, Christian; Greene, Jonathan R; Hildebrand, Samuel; Knox, Emily; Sapp, Ellen; Yamada, Nozomi; Furgal, Raymond; Miller, Rachael; Osborne, Georgina F; Chase, Kathryn; Luu, Eric; Freedman, Jason; Bramato, Brianna; McHugh, Nicholas; Benoit, Vicky; O'Reilly, Daniel; Greer, Paul; Bates, Gillian P; Vogt, Thomas F; Lee, Ramee; Howland, David; DiFiglia, Marian; Aronin, Neil; Khvorova, Anastasia

Exon 1-targeting miRNA reduces the pathogenic exon 1 HTT protein in Huntington's disease models

靶向外显子1的miRNA可降低亨廷顿病模型中致病性外显子1 HTT蛋白的表达。

Sogorb-Gonzalez, Marina; Landles, Christian; Caron, Nicholas S; Stam, Anouk; Osborne, Georgina; Hayden, Michael R; Howland, David; van Deventer, Sander; Bates, Gillian P; Vallès, Astrid; Evers, Melvin

Development of novel bioassays to detect soluble and aggregated Huntingtin proteins on three technology platforms

在三种技术平台上开发用于检测可溶性和聚集性亨廷顿蛋白的新型生物测定方法

Landles, Christian; Milton, Rebecca E; Jean, Alexandre; McLarnon, Stuart; McAteer, Sean J; Taxy, Bridget A; Osborne, Georgina F; Zhang, Chuangchuang; Duan, Wenzhen; Howland, David; Bates, Gillian P

Promotion of somatic CAG repeat expansion by Fan1 knock-out in Huntington's disease knock-in mice is blocked by Mlh1 knock-out

在亨廷顿病敲入小鼠中,Fan1 敲除促进体细胞 CAG 重复序列扩增的现象可被 Mlh1 敲除阻断。

Loupe, Jacob M; Pinto, Ricardo Mouro; Kim, Kyung-Hee; Gillis, Tammy; Mysore, Jayalakshmi S; Andrew, Marissa A; Kovalenko, Marina; Murtha, Ryan; Seong, IhnSik; Gusella, James F; Kwak, Seung; Howland, David; Lee, Ramee; Lee, Jong-Min; Wheeler, Vanessa C; MacDonald, Marcy E

Transcriptional Assessment of Striatal mRNAs as Valid Biomarkers of Disease Progression in Three Mouse Models of Huntington's Disease

纹状体mRNA转录组评估作为亨廷顿病三种小鼠模型疾病进展的有效生物标志物

Ghavami, Afshin; Olsen, Michael; Kwan, Mei; Beltran, Jose; Shea, John; Ramboz, Sylvie; Duan, Wenzhen; Lavery, Daniel; Howland, David; Park, Larry C

Extensive Expression Analysis of Htt Transcripts in Brain Regions from the zQ175 HD Mouse Model Using a QuantiGene Multiplex Assay

利用 QuantiGene 多重检测法对 zQ175 HD 小鼠模型脑区中 Htt 转录本进行广泛的表达分析

Papadopoulou, Aikaterini S; Gomez-Paredes, Casandra; Mason, Michael A; Taxy, Bridget A; Howland, David; Bates, Gillian P

Phenotype onset in Huntington's disease knock-in mice is correlated with the incomplete splicing of the mutant huntingtin gene.

亨廷顿病基因敲入小鼠的表型出现与突变亨廷顿基因的不完全剪接有关

Franich Nicholas R, Hickey Miriam A, Zhu Chunni, Osborne Georgina F, Ali Nadira, Chu Tiffany, Bove Nicholas H, Lemesre Vincent, Lerner Renata P, Zeitlin Scott O, Howland David, Neueder Andreas, Landles Christian, Bates Gillian P, Chesselet Marie-Francoise

Time-Restricted Feeding Improves Circadian Dysfunction as well as Motor Symptoms in the Q175 Mouse Model of Huntington's Disease

限时喂食可改善亨廷顿病Q175小鼠模型的昼夜节律紊乱和运动症状

Wang, Huei-Bin; Loh, Dawn H; Whittaker, Daniel S; Cutler, Tamara; Howland, David; Colwell, Christopher S

MicroRNA signatures of endogenous Huntingtin CAG repeat expansion in mice

小鼠内源性亨廷顿蛋白CAG重复序列扩增的microRNA特征

Langfelder, Peter; Gao, Fuying; Wang, Nan; Howland, David; Kwak, Seung; Vogt, Thomas F; Aaronson, Jeffrey S; Rosinski, Jim; Coppola, Giovanni; Horvath, Steve; Yang, X William