日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Cell-type-specific alternative splicing in the brain and kidney of a Setbp1S858R Schinzel-Giedion syndrome mouse

Setbp1S858R Schinzel-Giedion综合征小鼠脑和肾脏中细胞类型特异性选择性剪接

Soelter, Tabea M; Jones, Emma F; Howton, Timothy C; Crumley, Anthony B; Wilk, Elizabeth J; Lasseigne, Brittany N

Macrophage Accumulation and Cyst Expansion in Pkd2 , Ift88 , and Double Mutant Mouse Models

Pkd2、Ift88 和双突变小鼠模型中的巨噬细胞聚集和囊肿扩张

Li, Zhang; Hombal, Raksha P; Wang, Jun; Cherakara, Sreelakshmi; Howton, Timothy C; Zimmerman, Kurt A; Collawn, James F; Andersen, Reagan S; Haycraft, Courtney J; Croyle, Mandy J; Parant, John M; Lasseigne, Brittany N; Yoder, Bradley K

Identifying and exploiting combinatorial synthetic lethality by characterizing adaptive kinome rewiring of EGFRvIII-driven glioblastoma

通过表征 EGFRvIII 驱动的胶质母细胞瘤的适应性激酶组重编程,识别和利用组合合成致死性

Lin, Benjamin; Shelton, Abigail K; Smithberger, Erin; Ziebro, Julia; Skinner, Kasey R; Bash, Ryan E; Kirkman, Richard; Stamper, Allie; Butler, Madison; Flores, Alex; Angus, Steven P; East, Michael P; Cloughesy, Timothy F; Nathanson, David A; Berens, Michael E; Sarkaria, Jann N; Binder, Zev A; O'Rourke, Donald M; Howton, Timothy C; Lasseigne, Brittany N; Willey, Christopher D; Johnson, Gary L; Hjelmeland, Anita B; Furnari, Frank B; Miller, C Ryan

Evaluation of altered cell-cell communication between glia and neurons in the hippocampus of 3xTg-AD mice at two time points

在两个时间点评估3xTg-AD小鼠海马中神经胶质细胞和神经元之间细胞间通讯的改变

Soelter, Tabea M; Howton, Timothy C; Wilk, Elizabeth J; Whitlock, Jordan H; Clark, Amanda D; Birnbaum, Allison; Patterson, Dalton C; Cortes, Constanza J; Lasseigne, Brittany N

Muscle Ultrasound: A Novel Noninvasive Tool for Early Detection of Developing Insulin Resistance and Lower Muscle Mass in Obesity

肌肉超声:一种用于早期检测肥胖患者胰岛素抵抗和肌肉量减少的新型无创工具

Soliman, Steven B; Chugh, Olivia K; Leuteneker, Jacob E; Tuska, Becca; Ye, Wen; Zhang, Tao; Rode, Thomas; Howton, Suzette M; Buras, Eric D; Horowitz, Jeffrey F

Altered glia-neuron communication in Alzheimer's Disease affects WNT, p53, and NFkB Signaling determined by snRNA-seq

阿尔茨海默病中神经胶质细胞与神经元通讯的改变会影响WNT、p53和NF-κB信号通路,这一发现已通过snRNA-seq技术证实。

Soelter, Tabea M; Howton, Timothy C; Clark, Amanda D; Oza, Vishal H; Lasseigne, Brittany N

Long-read RNA sequencing identifies region- and sex-specific C57BL/6J mouse brain mRNA isoform expression and usage

长读长RNA测序鉴定出C57BL/6J小鼠脑组织中区域和性别特异性的mRNA亚型表达和使用情况

Jones, Emma F; Howton, Timothy C; Flanary, Victoria L; Clark, Amanda D; Lasseigne, Brittany N

Signature reversion of three disease-associated gene signatures prioritizes cancer drug repurposing candidates

三种疾病相关基因特征的逆转优先考虑癌症药物再利用候选药物

Jennifer L Fisher, Elizabeth J Wilk, Vishal H Oza, Sam E Gary, Timothy C Howton, Victoria L Flanary, Amanda D Clark, Anita B Hjelmeland, Brittany N Lasseigne

Altered Glia-Neuron Communication in Alzheimer's Disease Affects WNT, p53, and NFkB Signaling Determined by snRNA-seq

阿尔茨海默病中神经胶质细胞-神经元通讯的改变会影响WNT、p53和NF-κB信号通路,该结果通过snRNA-seq技术确定。

Soelter, Tabea M; Howton, Timothy C; Clark, Amanda D; Oza, Vishal H; Lasseigne, Brittany N

Prioritized polycystic kidney disease drug targets and repurposing candidates from pre-cystic and cystic mouse Pkd2 model gene expression reversion

优先考虑多囊肾病药物靶点,并从囊前期和囊性小鼠 Pkd2 模型基因表达逆转中筛选出再利用候选药物

Wilk, Elizabeth J; Howton, Timothy C; Fisher, Jennifer L; Oza, Vishal H; Brownlee, Ryan T; McPherson, Kasi C; Cleary, Hannah L; Yoder, Bradley K; George, James F; Mrug, Michal; Lasseigne, Brittany N