日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

CTC1-STN1-TEN1 controls DNA break repair pathway choice via DNA end resection blockade

CTC1-STN1-TEN1 通过阻断 DNA 末端切除来控制 DNA 断裂修复途径的选择

Rogers, Cody M; Kaur, Hardeep; Swift, Michelle L; Raina, Vivek B; Zhou, Shuo; Kawale, Ajinkya S; Syed, Shahrez; Kelly, Korilynn G; Jasper, Angela M; Salunkhe, Sameer; Kwon, Youngho; Wang, Jeffrey; Shabestari, Aida Badamchi; Daley, James M; Sacks, Adam; Gaczynska, Maria E; Osmulski, Pawel A; Rawal, Yashpal; Tomimatsu, Nozomi; Gayther, Simon A; Lawrenson, Kate; Burma, Sandeep; Wasmuth, Elizabeth V; Olsen, Shaun K; Zhao, Weixing; Hromas, Robert; Libich, David S; Mazin, Alexander V; Zhou, Daohong; Greene, Eric C; Chowdhury, Dipanjan; Sung, Patrick

CD36-mediated endocytosis of proteolysis-targeting chimeras.

CD36介导的靶向蛋白水解嵌合体的内吞作用

Wang Zhengyu, Pan Bo-Syong, Manne Rajesh Kumar, Chen Jungang, Lv Dongwen, Wang Minmin, Tran Phuc, Weldemichael Tsigereda, Yan Wei, Zhou Hongfei, Martinez Gloria M, Shao Jingwei, Hsu Che-Chia, Hromas Robert, Zhou Daohong, Qin Zhiqiang, Lin Hui-Kuan, Li Hong-Yu

First in human phase 1 study of DT2216, a selective BCL-xL degrader, in patients with relapsed/refractory solid malignancies

DT2216(一种选择性 BCL-xL 降解剂)在复发/难治性实体恶性肿瘤患者中的首次人体 I 期研究

Mahadevan, Daruka; Barve, Minal; Mahalingam, Devalingam; Parekh, Jay; Kurman, Michael; Strauss, James; Tremaine, Larry; Hromas, Robert; Sills, Joshua; McCulloch, John; Harkey, John; Suberg, Stacy; Zimmerman, Lisa; Zheng, Guangrong; Zhou, Daohong

A BCL-xL/BCL-2 PROTAC effectively clears senescent cells in the liver and reduces MASH-driven hepatocellular carcinoma in mice

BCL-xL/BCL-2 PROTAC 能有效清除肝脏中的衰老细胞,并减少小鼠体内 MASH 驱动的肝细胞癌。

Yang, Yang; Jn-Simon, Natacha; He, Yonghan; Sun, Chunbao; Zhang, Peiyi; Hu, Wanyi; Tian, Tian; Zeng, Huadong; Basha, Sreenivasulu; Huerta, Araceli S; Sun, Lu-Zhe; Yin, Xian-Ming; Hromas, Robert; Zheng, Guangrong; Pi, Liya; Zhou, Daohong

Epigenetic silencing of DNA sensing pathway by FOXM1 blocks stress ligand-dependent antitumor immunity and immune memory.

FOXM1 通过表观遗传沉默 DNA 感知通路,阻断应激配体依赖的抗肿瘤免疫和免疫记忆

Timilsina Santosh, Huang Jian Yu, Abdelfattah Nourhan, Medina Daisy, Singh Deepika, Abdulsahib Shahad, Subbarayalu Panneerdoss, Do Trong Phat, Venkata Prabhakar Pitta, Nirzhor Saif, Prochnau Jack, Bhandari Mukund, Zheng Siyuan, Chen Yidong, Huang Gang, Mukherjee Neelam, Hromas Robert, Sung Patrick, Kaklamani Virginia, Vadlamudi Ratna, Zhang Nu, Rao Manjeet K

Colibactin Exerts Androgen-dependent and -independent Effects on Prostate Cancer

大肠杆菌素对前列腺癌具有雄激素依赖性和非依赖性作用

Agrawal, Raag; Al-Hiyari, Sarah; Hugh-White, Rupert; Hromas, Robert; Patel, Yash; Williamson, Elizabeth A; Mootor, Mohammed F E; Gonzalez, Alfredo; Fu, Jianmin; Haas, Roni; Jordan, Madison; Wickes, Brian L; Mohammed, Ghouse; Tian, Mao; Doris, Molly J; Jobin, Christian; Wernke, Kevin M; Pan, Yu; Yamaguchi, Takafumi N; Herzon, Seth B; Boutros, Paul C; Liss, Michael A

Distinct roles of the two BRCA2 DNA-binding domains in DNA damage repair and replication fork preservation.

BRCA2 的两个 DNA 结合域在 DNA 损伤修复和复制叉保存中发挥着不同的作用

Neal Francisco E, Li Wenjing, Uhrig Mollie E, Katz Jeffrey N, Syed Shahrez, Sharma Neelam, Dutta Arijit, Burma Sandeep, Hromas Robert, Mazin Alexander V, Dray Eloise, Libich David S, Olsen Shaun K, Wasmuth Elizabeth V, Zhao Weixing, Sørensen Claus S, Wiese Claudia, Kwon Youngho, Sung Patrick

Erratum: Phase II Trial of the PARP Inhibitor, Niraparib, in BAP1 and Other DNA Damage Response Pathway-Deficient Neoplasms

更正:PARP抑制剂尼拉帕尼治疗BAP1和其他DNA损伤反应通路缺陷型肿瘤的II期试验

George, Thomas J; Lee, Ji-Hyun; DeRemer, David L; Hosein, Peter J; Staal, Steven; Markham, Merry Jennifer; Jones, Dennie; Daily, Karen C; Chatzkel, Jonathan A; Ramnaraign, Brian H; Close, Julia L; Ezenwajiaku, Nkiruka; Murphy, Martina C; Allegra, Carmen J; Rogers, Sherise; Zhang, Zhongyue; Li, Derek; Srinivasan, Gayathri; Shaheen, Montaser; Hromas, Robert

The DNA Repair Component EEPD1 Regulates Actin Polymerization

DNA修复组分EEPD1调控肌动蛋白聚合

Hromas, Robert; Kirby, Austin; Carrillo, Andrew; Jasiwal, Aruna; Kong, Kimi; Tran, Manh Tien; Arris, Dominic; Williamson, Elizabeth A

Promotion of DNA end resection by BRCA1-BARD1 in homologous recombination.

BRCA1-BARD1在同源重组中促进DNA末端切除

Salunkhe Sameer, Daley James M, Kaur Hardeep, Tomimatsu Nozomi, Xue Chaoyou, Raina Vivek B, Jasper Angela M, Rogers Cody M, Li Wenjing, Zhou Shuo, Mojidra Rahul, Kwon Youngho, Fang Qingming, Ji Jae-Hoon, Badamchi Shabestari Aida, Fitzgerald O'Taveon, Dinh Hoang, Mukherjee Bipasha, Habib Amyn A, Hromas Robert, Mazin Alexander V, Wasmuth Elizabeth V, Olsen Shaun K, Libich David S, Zhou Daohong, Zhao Weixing, Greene Eric C, Burma Sandeep, Sung Patrick