日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The Alzheimer's disease-linked protease BACE2 cleaves VEGFR3 and modulates its signaling

阿尔茨海默病相关蛋白酶 BACE2 可裂解 VEGFR3 并调节其信号传导

Andree Schmidt, Brian Hrupka, Frauke van Bebber, Sanjay Sunil Kumar, Xiao Feng, Sarah K Tschirner, Marlene Aßfalg, Stephan A Müller, Laura Sophie Hilger, Laura I Hofmann, Martina Pigoni, Georg Jocher, Iryna Voytyuk, Emily L Self, Mana Ito, Kana Hyakkoku, Akimasa Yoshimura, Naotaka Horiguchi, Regina

BACE inhibitor treatment of mice induces hyperactivity in a Seizure-related gene 6 family dependent manner without altering learning and memory

BACE 抑制剂治疗小鼠会以癫痫相关基因 6 家族依赖的方式诱发过度活跃,而不会改变学习和记忆

A Nash, H J M Gijsen, B J Hrupka, K S-L Teng, S F Lichtenthaler, H Takeshima, J M Gunnersen, K M Munro

Seizure protein 6 and its homolog seizure 6-like protein are physiological substrates of BACE1 in neurons

癫痫蛋白 6 及其同源物癫痫 6 样蛋白是神经元中 BACE1 的生理底物

Martina Pigoni, Johanna Wanngren, Peer-Hendrik Kuhn, Kathryn M Munro, Jenny M Gunnersen, Hiroshi Takeshima, Regina Feederle, Iryna Voytyuk, Bart De Strooper, Mikail D Levasseur, Brian J Hrupka, Stephan A Müller, Stefan F Lichtenthaler

N-aryl piperazine metabotropic glutamate receptor 5 positive allosteric modulators possess efficacy in preclinical models of NMDA hypofunction and cognitive enhancement

N-芳基哌嗪类代谢型谷氨酸受体5正向变构调节剂在NMDA功能减退和认知增强的临床前模型中具有疗效。

Gregory, K J; Herman, E J; Ramsey, A J; Hammond, A S; Byun, N E; Stauffer, S R; Manka, J T; Jadhav, S; Bridges, T M; Weaver, C D; Niswender, C M; Steckler, T; Drinkenburg, W H; Ahnaou, A; Lavreysen, H; Macdonald, G J; Bartolomé, J M; Mackie, C; Hrupka, B J; Caron, M G; Daigle, T L; Lindsley, C W; Conn, P J; Jones, C K