Amide-to-ester substitution as a stable alternative to N-methylation for increasing membrane permeability in cyclic peptides.
酰胺到酯的取代是提高环肽膜渗透性的稳定替代方法，可替代 N-甲基化
期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-023-36978-z
Hosono Yuki, Uchida Satoshi, Shinkai Moe, Townsend Chad E, Kelly Colin N, Naylor Matthew R, Lee Hsiau-Wei, Kanamitsu Kayoko, Ishii Mayumi, Ueki Ryosuke, Ueda Takumi, Takeuchi Koh, Sugita Masatake, Akiyama Yutaka, Lokey Scott R, Morimoto Jumpei, Sando Shinsuke
