日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Structure-Based Development of Ultra-Broad-Spectrum 3C-Like Protease Inhibitors

基于结构的超广谱3C样蛋白酶抑制剂的开发

期刊:Advanced Science
影响因子:14.1
doi:10.1002/advs.202512342
Su, Haixia; Nie, Tianqing; Chen, Guofeng; Xiong, Muya; Zhang, Yumin; Wu, Guoqing; You, Mengyuan; Xie, Hang; He, Jian; Xiong, Yanchao; Hu, Hangchen; Zhao, Wenfeng; Li, Minjun; Xiao, Gengfu; Zhang, Leike; Xu, Yechun
发表日期：2026
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Fusion Strategy of DNA-Encoded Libraries Drives Discovery of Allosteric Inhibitors of SARS-CoV‑2 RdRp

DNA编码文库的融合策略推动了SARS-CoV-2 RNA依赖性RNA聚合酶（RdRp）变构抑制剂的发现。

期刊:JACS Au
影响因子:8.7
doi:10.1021/jacsau.5c01698
Li, Linjie; Wang, Xudong; Ding, Peiqi; Shen, Xuanjing; Hu, Hangchen; Wang, Xiaoxi; Jin, Rui; Wu, Xinyuan; Zhang, Yiwei; Lu, Weiwei; Yue, Jinfeng; Xu, H Eric; Yin, Wanchao; Xu, Yechun; Lu, Xiaojie
SARS-CoV-2
发表日期：2026
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De novo design of protein condensation inhibitors by targeting an allosteric site of cGAS.

通过靶向 cGAS 的变构位点，从头设计蛋白质缩合抑制剂

期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-025-60297-0
Zhao Wenfeng, Chen Guofeng, He Jian, Shen Xiaofang, Xiong Muya, Xiong Liwei, Qi Zhihao, Xie Hang, Li Wanchen, Li Jiameng, Dou Huixia, Hu Hangchen, Su Haixia, Shao Qiang, Li Minjun, Sun Hongbin, Xu Yechun
免疫/内分泌
发表日期：2025
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Structure-based design of potent and selective inhibitors targeting RIPK3 for eliminating on-target toxicity in vitro.

基于结构的高效选择性RIPK3抑制剂设计，可消除体外靶向毒性

期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-025-59432-8
Su Haixia, Chen Guofeng, Xie Hang, Li Wanchen, Xiong Muya, He Jian, Hu Hangchen, Zhao Wenfeng, Shao Qiang, Li Minjun, Zhao Qiang, Xu Yechun
信号转导
发表日期：2025
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Covalent DNA-Encoded Library Workflow Drives Discovery of SARS-CoV-2 Nonstructural Protein Inhibitors

共价DNA编码文库工作流程推动SARS-CoV-2非结构蛋白抑制剂的发现

期刊:Journal of the American Chemical Society
影响因子:15.6
doi:10.1021/jacs.4c12992
Wang, Xudong; Xiong, Liwei; Zhu, Ying; Liu, Sixiu; Zhao, Wenfeng; Wu, Xinyuan; Seydimemet, Mengnisa; Li, Linjie; Ding, Peiqi; Lin, Xian; Liu, Jiaxiang; Wang, Xuan; Duan, Zhiqiang; Lu, Weiwei; Suo, Yanrui; Cui, Mengqing; Yue, Jinfeng; Jin, Rui; Zheng, Mingyue; Xu, Yechun; Mei, Lianghe; Hu, Hangchen; Lu, Xiaojie
SARS-CoV-2
发表日期：2024
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Chemical Space Profiling of SARS-CoV-2 PL(pro) Using DNA-Encoded Focused Libraries

利用DNA编码的聚焦文库对SARS-CoV-2 PL(pro)进行化学空间分析

期刊:ACS Medicinal Chemistry Letters
影响因子:4
doi:10.1021/acsmedchemlett.4c00069
Wang, Xudong; Zhu, Ying; Zhao, Qingyi; Lu, Weiwei; Xu, Yechun; Hu, Hangchen; Lu, Xiaojie
SARS-CoV-2
发表日期：2024
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Unraveling the catalytic mechanism of SARS-CoV-2 papain-like protease with allosteric modulation of C270 mutation using multiscale computational approaches

利用多尺度计算方法揭示SARS-CoV-2木瓜蛋白酶样蛋白酶的催化机制及其对C270突变的变构调节作用

期刊:Chemical Science
影响因子:7.4
doi:10.1039/d3sc00166k
Shao, Qiang; Xiong, Muya; Li, Jiameng; Hu, Hangchen; Su, Haixia; Xu, Yechun
SARS-CoV-2
发表日期：2023
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Identification of Cysteine 270 as a Novel Site for Allosteric Modulators of SARS-CoV-2 Papain-Like Protease

鉴定半胱氨酸270为SARS-CoV-2木瓜蛋白酶样蛋白酶变构调节剂的新位点

期刊:Angewandte Chemie-International Edition
影响因子:16.9
doi:10.1002/anie.202212378
Hu, Hangchen; Wang, Qian; Su, Haixia; Shao, Qiang; Zhao, Wenfeng; Chen, Guofeng; Li, Minjun; Xu, Yechun
SARS-CoV-2
发表日期：2022
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