Optimized rAAV8 targeting acinar KLF4 ameliorates fibrosis in chronic pancreatitis via exosomes-enriched let-7s suppressing pancreatic stellate cells activation.
优化的 rAAV8 靶向腺泡 KLF4，通过富含 let-7 的外泌体抑制胰腺星状细胞活化，从而改善慢性胰腺炎的纤维化
期刊:Molecular Therapy
影响因子:12
doi:10.1016/j.ymthe.2024.06.030
Zhao Yating, Feng Yongpu, Sun Fengyuan, Li Lei, Chen Jiayu, Song Yingxiao, Zhu Wenbo, Hu Xiulin, Li Zhaoshen, Kong Fanyang, Du Yiqi, Kong Xiangyu
