日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Impact of KRAS-G12 Mutations on the KRAS-GTP Bound Conformational Dynamics: Structure, Free Energy Barriers and Drugging Pockets

KRAS-G12突变对KRAS-GTP结合构象动力学的影响:结构、自由能垒和药物结合口袋

Hu, Zheyao; Sha, Zigan; Martí, Jordi; Guo, Shu-Juan; Tao, Sheng-Ce

Sensitive and specific affinity purification-mass spectrometry assisted by PafA-mediated proximity labeling.

灵敏且特异的亲和纯化-质谱法,借助 PafA 介导的邻近标记。

Luo Shihan, Xie Lijuan, Yang Lin, Hu Zheyao, Wang Lei, Wang Yueqin, Li Qingqing, Guo Shujuan, Tao Shengce, Jiang Hewei

Isomer-sourced structure iteration methods for in silico development of inhibitors: Inducing GTP-bound NRAS-Q61 oncogenic mutations to an "off-like" state

基于异构体的结构迭代方法用于抑制剂的计算机辅助开发:诱导 GTP 结合的 NRAS-Q61 致癌突变进入“关闭样”状态

Hu, Zheyao; Martí, Jordi

Discovering and Targeting Dynamic Drugging Pockets of Oncogenic Proteins: The Role of Magnesium in Conformational Changes of the G12D Mutated Kirsten Rat Sarcoma-Guanosine Diphosphate Complex

发现并靶向致癌蛋白的动态药物结合位点:镁在G12D突变型Kirsten大鼠肉瘤-鸟苷二磷酸复合物构象变化中的作用

Hu, Zheyao; Marti, Jordi

In Silico Drug Design of Benzothiadiazine Derivatives Interacting with Phospholipid Cell Membranes

利用计算机辅助设计与磷脂细胞膜相互作用的苯并噻二嗪衍生物

Hu, Zheyao; Marti, Jordi