日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

CREB5 regulates stem cell-like transcriptional programs to enhance tumor progression in prostate cancer

CREB5 调控干细胞样转录程序,从而促进前列腺癌的肿瘤进展

Makovec, Allison; Phoenix, John T; Bergom, Hannah E; Boytim, Ella; Gustafson, Ava P; Deacon, Aiden; Tape, Sydney; Ali, Atef; Ludwig, Megan; Pitzen, Samuel P; Moline, David; Richter, Camden; Longie, Hudson; Su, Mei-Chi; Jena, Sampreeti; Likasitwatanakul, Pornlada; Drake, Justin M; Huang, R Stephanie; Hahn, William C; Rennhack, Jonathan P; Dehm, Scott M; Kregel, Steven; Antonarakis, Emmanuel S; Hwang, Justin

Germline-Somatic Interactions in BRCA-Associated Cancers: Unique Molecular Profiles and Clinical Outcomes Linking ATM to TP53 Synthetic Essentiality

BRCA相关癌症中的种系-体细胞相互作用:独特的分子特征和临床结果将ATM与TP53合成必需性联系起来

Arafa, Ali T; Yadav, Siddhartha; Marshall, Catherine H; Mauer, Elizabeth; Huang, Minxuan; Yilma, Binyam; van der Pol, Ymke; Fragkogianni, Stamatina; Teslow, Emily A; Kellen, Samuel; Boytim, Ella; Luo, Christine; Ludwig, Megan; Zhang, Weijie; Jayaraj, Arockia; Armstrong, Deborah K; Isaacs, William B; Drake, Justin M; Nguyen, Hai Dang; Huang, R Stephanie; Chao, Calvin Y; Lou, Emil; Dehm, Scott M; Couch, Fergus J; Hwang, Justin H; Antonarakis, Emmanuel S

Comparative transcriptomics reveals a mixed basal, club, and hillock epithelial cell identity in castration-resistant prostate cancer

比较转录组学揭示去势抵抗性前列腺癌中混合的基底细胞、棒状细胞和丘状细胞上皮细胞特性

Pitzen, Samuel P; Rudenick, Amber N; Qiu, Yinjie; Zhang, Weijie; Munro, Sarah A; McCluskey, Braedan M; Forster, Colleen; Bergom, Hannah E; Ali, Atef; Boytim, Ella; Lafin, John T; Linder, Simon; Ismail, Mazlina; Devlies, Wout; Sessions, Conner J; Claessens, Frank; Joniau, Steven; Attard, Gerhardt; Zwart, Wilbert; Nelson, Peter S; Corey, Eva; Wang, Yuzhuo; Lang, Joshua M; Beltran, Himisha; Strand, Douglas; Antonarakis, Emmanuel S; Hwang, Justin; Murugan, Paari; Huang, R Stephanie; Dehm, Scott M

Combined XPO1 Inhibition and Parthenolide Treatment Can Be Efficacious in Treating Triple-Negative Breast Cancer

XPO1抑制剂联合帕特诺苷治疗可有效治疗三阴性乳腺癌

Paulson, Amy L; Elmorsi, Radwa M; Lee, Adam M; Huang, R Stephanie

Novel Mixed Cancer-Cell Models Designed to Capture Inter-Patient Tumor Heterogeneity for Accurate Evaluation of Drug Combinations

新型混合癌细胞模型旨在捕捉患者间肿瘤异质性,从而准确评估药物组合

Jena, Sampreeti; Kim, Daniel C; Lee, Adam M; Zhang, Weijie; Zhan, Kevin; Elmorsi, Radwa M; Li, Yingming; Dehm, Scott M; Huang, R Stephanie

Novel mixed cancer-cell models designed to capture inter-patient tumor heterogeneity for accurate evaluation of drug combinations

新型混合癌细胞模型旨在捕捉患者间肿瘤异质性,从而准确评估药物组合

Jena, Sampreeti; Kim, Daniel; Lee, Adam M; Zhang, Weijie; Zhan, Kevin; Li, Yingming; Dehm, Scott M; Huang, R Stephanie

Heterogeneous therapy-resistant cancer cells have distinct and exploitable drug sensitivity profiles.

异质性耐药癌细胞具有独特的、可利用的药物敏感性特征

Busch Gianna T, Boe Ryan H, Li Jingxin, Gruener Robert F, Arnett Miles J, Ravindran Pavithran T, Herlyn Meenhard, Huang R Stephanie, Raj Arjun

Integration of Pan-Cancer Cell Line and Single-Cell Transcriptomic Profiles Enables Inference of Therapeutic Vulnerabilities in Heterogeneous Tumors

整合泛癌细胞系和单细胞转录组谱分析,可推断异质性肿瘤的治疗弱点

Zhang, Weijie; Maeser, Danielle; Lee, Adam; Huang, Yingbo; Gruener, Robert F; Abdelbar, Israa G; Jena, Sampreeti; Patel, Anand G; Huang, R Stephanie

A review of computational methods for predicting cancer drug response at the single-cell level through integration with bulk RNAseq data

本文综述了通过整合批量RNA测序数据,在单细胞水平上预测癌症药物反应的计算方法。

Maeser, Danielle; Zhang, Weijie; Huang, Yingbo; Huang, R Stephanie

Computer-aided drug discovery strategies for novel therapeutics for prostate cancer leveraging next-generating sequencing data

利用新一代测序数据进行前列腺癌新型疗法的计算机辅助药物发现策略

Zhang, Weijie; Huang, R Stephanie