日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Structure-based design of an opioid receptor modulator for enhanced morphine analgesia

基于结构的阿片受体调节剂设计及其在增强吗啡镇痛中的应用

Wang, Yue; Luo, Ping; Xu, Haiyan; Zhan, Li; Sakamoto, Kensuke; Li, Mingyu; Wang, Jing; Huang, Xi-Ping; Zhou, Jianhui; Liu, Tao; Suo, Yanrui; Fan, Wenjia; He, Xinheng; Xu, Youwei; Cai, Yongjie; Wang, Chao; Zhao, Yuxi; Dai, Antao; Lai, Yali; Yuan, Qingning; Hu, Wen; Wu, Kai; Yang, Dehua; Cheng, Xi; Lu, Xiaojie; Krumm, Brian; Kenakin, Terry; Zhang, Jian; Roth, Bryan L; Gao, Zhaobing; Xu, H Eric; Zhuang, Youwen

Large Library Docking for Polypharmacology

用于多药理学的大型库对接

Wu, Yujin; Vigneron, Seth; Braz, Joao; Srinivasan, Karthik; Fink, Elissa A; Huang, Xi-Ping; Xu, Xinyu; Huebner, Harald; Kim, Joseph Y; Wang, Jing; Pfeiffer, Tara; Sakamoto, Kensuke; Radchenko, Dmytro S; Rodriguiz, Ramona M; Moroz, Yurii S; Irwin, John J; Gmeiner, Peter; Billesboelle, Christian; Roth, Bryan L; Basbaum, Allan I; Manglik, Aashish; Wetsel, William C; Shoichet, Brian K

Xylazine's κ opioid agonist activity is not shared with other FDA-approved α(2)-adrenergic agonists

赛拉嗪的κ阿片受体激动剂活性与其他FDA批准的α(2)-肾上腺素能激动剂不同。

Huang, Xi-Ping; Krumm, Brian E; Bedard, Madigan L; McElligott, Zoe A; Roth, Bryan L

The selectivity implications of docking libraries with greater and lesser similarities to bio-like molecules

对接库与生物分子相似度高低的影响

Hall, Brendan W; Sakamoto, Kensuke; Huang, Xi-Ping; Irwin, John J; Shoichet, Brian K; Roth, Bryan L

A cryptic pocket in CB1 drives peripheral and functional selectivity

CB1 中的一个隐蔽口袋驱动外周和功能选择性

Rangari, Vipin Ashok; O'Brien, Evan S; Powers, Alexander S; Slivicki, Richard A; Bertels, Zachariah; Appourchaux, Kevin; Aydin, Deniz; Ramos-Gonzalez, Nokomis; Mwirigi, Juliet; Lin, Li; Mangutov, Elizaveta; Sobecks, Briana L; Awad-Agbaria, Yaseen; Uphade, Manoj B; Aguilar, Jhoan; Peddada, Teja Nikhil; Shiimura, Yuki; Huang, Xi-Ping; Folarin-Hines, Jakayla; Payne, Maria; Kalathil, Anirudh; Varga, Balazs R; Kobilka, Brian K; Pradhan, Amynah A; Cameron, Michael D; Kumar, Kaavya Krishna; Dror, Ron O; Gereau, Robert W 4th; Majumdar, Susruta

Structure-guided design of partial agonists at an opioid receptor.

基于结构的阿片受体部分激动剂设计

Varga Balazs R, Bernhard Sarah M, El Daibani Amal, Zaidi Saheem A, Lam Jordy H, Aguilar Jhoan, Appourchaux Kevin, Nazarova Antonina L, Kouvelis Alexa, Shinouchi Ryosuke, Hammond Haylee R, Eans Shainnel O, Weinreb Violetta, Margolis Elyssa B, Fay Jonathan F, Huang Xi-Ping, Pradhan Amynah, Katritch Vsevolod, McLaughlin Jay P, Majumdar Susruta, Che Tao

Total synthesis and biological activity of "carbamorphine": O-to-CH(2) replacement in the E-ring of the morphine core structure.

“卡巴吗啡”的全合成及生物活性:吗啡核心结构E环中的O-到-CH(2)取代

Akiyama Sota, Ople Rohini S, Kremsmair Alexander, Ramos-Gonzalez Nokomis, Nedungadan Thomas, Kennedy Brandon J, Appourchaux Kevin, Eans Shainnel O, Tsai Bowen A, Kraml Christina, Huang Xi-Ping, McLaughlin Jay P, Majumdar Susruta, Sarpong Richmond

Membrane Perturbations and Assay Interferences by Ivermectin Explain Its In Vitro SARS-CoV-2 Antiviral Activities and Lack of Translatability

伊维菌素引起的膜扰动和检测干扰解释了其体外抗SARS-CoV-2病毒活性及其缺乏转化性的原因

Eastman, Richard T; Rusinova, Radda; Herold, Karl F; Huang, Xi-Ping; Voss, Ty; White, Alex D; Hemmings, Hugh C Jr; Andersen, Olaf S; Dahlin, Jayme L

Differential Effects of Sodium on Agonist-Induced Conformational Transitions and Signaling at μ and κ Opioid Receptors

钠对μ和κ阿片受体激动剂诱导的构象转变和信号传导的不同影响

Kuijer, Michael Bram; Fulton, Camryn J; Albert, Talia L; Knobloch, Paloma; Wang, Jing; Krumm, Brian E; Che, Tao; Varga, Balazs R; Majumdar, Susruta; Katritch, Vsevolod; Gumpper, Ryan H; Kenakin, Terry; Huang, Xi-Ping; Roth, Bryan L

Differential effects of sodium on agonist-induced conformational transitions and signaling at μ and κ opioid receptors

钠对μ和κ阿片受体激动剂诱导的构象转变和信号传导的不同影响

Kuijer, Bram; Fulton, Camryn J; Albert, Talia L; Knobloch, Paloma M; Wang, Jing; Krumm, Brian E; Che, Tao; Varga, Balazs R; Majumdar, Susruta; Katritch, Vsevolod; Gumpper, Ryan H; Kenakin, Terry; Huang, Xi-Ping; Roth, Bryan L