日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Cytosolic calcium regulates hepatic mitochondrial oxidation, intrahepatic lipolysis, and gluconeogenesis via CAMKII activation.

胞质钙通过 CAMKII 激活调节肝线粒体氧化、肝内脂肪分解和糖异生

期刊:Cell Metabolism
影响因子:30.9
doi:10.1016/j.cmet.2024.07.016
LaMoia Traci E, Hubbard Brandon T, Guerra Mateus T, Nasiri Ali, Sakuma Ikki, Kahn Mario, Zhang Dongyan, Goodman Russell P, Nathanson Michael H, Sancak Yasemin, Perelis Mark, Mootha Vamsi K, Shulman Gerald I
线粒体
发表日期：2024
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SGLT2 inhibition alters substrate utilization and mitochondrial redox in healthy and failing rat hearts

SGLT2抑制剂可改变健康和衰竭大鼠心脏的底物利用率和线粒体氧化还原状态

期刊:Journal of Clinical Investigation
影响因子:13.6
doi:10.1172/JCI176708
Goedeke, Leigh; Ma, Yina; Gaspar, Rafael C; Nasiri, Ali; Lee, Jieun; Zhang, Dongyan; Galsgaard, Katrine Douglas; Hu, Xiaoyue; Zhang, Jiasheng; Guerrera, Nicole; Li, Xiruo; LaMoia, Traci; Hubbard, Brandon T; Haedersdal, Sofie; Wu, Xiaohong; Stack, John; Dufour, Sylvie; Butrico, Gina Marie; Kahn, Mario; Perry, Rachel J; Cline, Gary W; Young, Lawrence H; Shulman, Gerald I
SGLT2
线粒体
Rat
发表日期：2024
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Small molecule inhibition of glycogen synthase I reduces muscle glycogen content and improves biomarkers in a mouse model of Pompe disease.

小分子抑制糖原合成酶 I 可降低庞贝氏症小鼠模型的肌肉糖原含量并改善生物标志物

期刊:American Journal of Physiology-Endocrinology and Metabolism
影响因子:3.1
doi:10.1152/ajpendo.00175.2024
Gaspar Rafael Calais, Sakuma Ikki, Nasiri Ali, Hubbard Brandon T, LaMoia Traci E, Leitner Brooks P, Tep Samnang, Xi Yannan, Green Eric M, Ullman Julie C, Petersen Kitt Falk, Shulman Gerald I
信号转导
Mouse
发表日期：2024
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Distinct subcellular localisation of intramyocellular lipids and reduced PKCε/PKCθ activity preserve muscle insulin sensitivity in exercise-trained mice

肌细胞内脂质的独特亚细胞定位和降低的 PKCε/PKCθ 活性可维持运动训练小鼠的肌肉胰岛素敏感性

期刊:Diabetologia
影响因子:10.2
doi:10.1007/s00125-022-05838-8
Gaspar, Rafael C; Lyu, Kun; Hubbard, Brandon T; Leitner, Brooks P; Luukkonen, Panu K; Hirabara, Sandro M; Sakuma, Ikki; Nasiri, Ali; Zhang, Dongyan; Kahn, Mario; Cline, Gary W; Pauli, José Rodrigo; Perry, Rachel J; Petersen, Kitt F; Shulman, Gerald I
PKCε
细胞生物学
PKC
免疫/内分泌
发表日期：2023
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Metformin, phenformin, and galegine inhibit complex IV activity and reduce glycerol-derived gluconeogenesis

二甲双胍、苯乙双胍和加利根抑制复合物IV活性，从而降低甘油衍生的糖异生作用。

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.2122287119
LaMoia, Traci E; Butrico, Gina M; Kalpage, Hasini A; Goedeke, Leigh; Hubbard, Brandon T; Vatner, Daniel F; Gaspar, Rafael C; Zhang, Xian-Man; Cline, Gary W; Nakahara, Keita; Woo, Seungwan; Shimada, Atsuhiro; Hüttemann, Maik; Shulman, Gerald I
发表日期：2022
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