日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Hide and seek: targeting nuclear receptor PXR with inhibitors and PROTACs to improve drug efficacy and safety

捉迷藏：利用抑制剂和PROTAC靶向核受体PXR以提高药物疗效和安全性

期刊:Expert Opinion on Therapeutic Targets
影响因子:4.4
doi:10.1080/14728222.2026.2639693
Huber, Andrew D; Chen, Taosheng
信号转导
发表日期：2026
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First-in-Class Small Molecule Degrader of Pregnane X Receptor Enhances Chemotherapy Efficacy.

首创的小分子孕烷X受体降解剂增强化疗疗效

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.4c01926
Huber Andrew D, Jung Young-Hwan, Li Yongtao, Lin Wenwei, Wu Jing, Poudel Shyaron, Carrigan Annalise G, Mishra Ashutosh, High Anthony A, Chen Taosheng
其它
发表日期：2024
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A new mode of inhibition

一种新的抑制模式

期刊:Elife
影响因子:6.4
doi:10.7554/eLife.101446
Huber, Andrew D; Chen, Taosheng
发表日期：2024
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PROTAC-mediated activation, rather than degradation, of a nuclear receptor reveals complex ligand-receptor interaction network.

PROTAC介导的核受体激活（而非降解）揭示了复杂的配体-受体相互作用网络

期刊:Structure
影响因子:4.3
doi:10.1016/j.str.2024.09.016
Huber Andrew D, Lin Wenwei, Poudel Shyaron, Miller Darcie J, Chen Taosheng
其它
发表日期：2024
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Regulation of Nuclear Receptors PXR and CAR by Small Molecules and Signal Crosstalk: Roles in Drug Metabolism and Beyond

小分子对核受体PXR和CAR的调控及信号串扰：在药物代谢及其他领域的作用

期刊:Drug Metabolism and Disposition
影响因子:4
doi:10.1124/dmd.122.000858
Poudel, Shyaron; Huber, Andrew D; Chen, Taosheng
信号转导
代谢
发表日期：2023
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Novel Hepatitis B Virus Capsid-Targeting Antiviral That Aggregates Core Particles and Inhibits Nuclear Entry of Viral Cores

一种新型的乙型肝炎病毒衣壳靶向抗病毒药物，可聚集核心颗粒并抑制病毒核心进入细胞核

期刊:ACS Infectious Diseases
影响因子:3.8
doi:10.1021/acsinfecdis.8b00235
Huber, Andrew D; Pineda, Dallas L; Liu, Dandan; Boschert, Kelsey N; Gres, Anna T; Wolf, Jennifer J; Coonrod, Emily M; Tang, Jing; Laughlin, Thomas G; Yang, Qiongying; Puray-Chavez, Maritza N; Ji, Juan; Singh, Kamalendra; Kirby, Karen A; Wang, Zhengqiang; Sarafianos, Stefan G
微生物学
细胞生物学
肝炎
发表日期：2019
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A 2-Hydroxyisoquinoline-1,3-Dione Active-Site RNase H Inhibitor Binds in Multiple Modes to HIV-1 Reverse Transcriptase

2-羟基异喹啉-1,3-二酮活性位点RNase H抑制剂以多种模式与HIV-1逆转录酶结合

期刊:Antimicrobial Agents and Chemotherapy
影响因子:4.5
doi:10.1128/AAC.01351-17
Kirby, Karen A; Myshakina, Nataliya A; Christen, Martin T; Chen, Yue-Lei; Schmidt, Hilary A; Huber, Andrew D; Xi, Zhaoyong; Kim, Seongmi; Rao, Rohit K; Kramer, Skyler T; Yang, Qiongying; Singh, Kamalendra; Parniak, Michael A; Wang, Zhengqiang; Ishima, Rieko; Sarafianos, Stefan G
HIV
微生物学
发表日期：2017
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3-Hydroxypyrimidine-2,4-Diones as Novel Hepatitis B Virus Antivirals Targeting the Viral Ribonuclease H

3-羟基嘧啶-2,4-二酮类化合物作为新型乙型肝炎病毒抗病毒药物，靶向病毒核糖核酸酶H

期刊:Antimicrobial Agents and Chemotherapy
影响因子:4.5
doi:10.1128/AAC.00245-17
Huber, Andrew D; Michailidis, Eleftherios; Tang, Jing; Puray-Chavez, Maritza N; Boftsi, Maria; Wolf, Jennifer J; Boschert, Kelsey N; Sheridan, Megan A; Leslie, Maxwell D; Kirby, Karen A; Singh, Kamalendra; Mitsuya, Hiroaki; Parniak, Michael A; Wang, Zhengqiang; Sarafianos, Stefan G
微生物学
肝炎
发表日期：2017
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Sympathoexcitation in ANG II-salt hypertension involves reduced SK channel function in the hypothalamic paraventricular nucleus

血管紧张素Ⅱ-盐性高血压中的交感神经兴奋涉及下丘脑室旁核中 SK 通道功能的降低

期刊:American Journal of Physiology-Heart and Circulatory Physiology
影响因子:4.1
doi:10.1152/ajpheart.00832.2014
Robert A Larson, Le Gui, Michael J Huber, Andrew D Chapp, Jianhua Zhu, Lila P LaGrange, Zhiying Shan, Qing-Hui Chen
心血管
神经
高血压
发表日期：2015
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SAMHD1 has differential impact on the efficacies of HIV nucleoside reverse transcriptase inhibitors

SAMHD1对HIV核苷类逆转录酶抑制剂的疗效有差异性影响

期刊:Antimicrobial Agents and Chemotherapy
影响因子:4.5
doi:10.1128/AAC.02745-14
Huber, Andrew D; Michailidis, Eleftherios; Schultz, Megan L; Ong, Yee T; Bloch, Nicolin; Puray-Chavez, Maritza N; Leslie, Maxwell D; Ji, Juan; Lucas, Anthony D; Kirby, Karen A; Landau, Nathaniel R; Sarafianos, Stefan G
HIV
SAMHD1
微生物学
发表日期：2014
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