日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Advances in BRET probes for intracellular target engagement studies

用于细胞内靶标结合研究的BRET探针的进展

Capener, Jacob L; Schwalm, Martin P; Vasta, James D; Michaud, Ani; Teske, Kelly A; Marsiglia, William M; Huber, Kilian V M; Dar, Arvin C; Knapp, Stefan; Axtman, Alison D; Robers, Matthew B

Phenomics-Based Discovery of Novel Orthosteric Choline Kinase Inhibitors

基于表型组学的新型正构胆碱激酶抑制剂的发现

Bauer, Ludwig G; Ward, Jennifer A; Díaz-Sáez, Laura; Sundström, Yvonne; Tolvanen, Tuomas; Alarcón Barrera, Juan Carlos; Kostidis, Sarantos; Rogers, Catherine M; Panagakou, Ioanna; Singh, Usha; Rothweiler, Elisabeth M; Gonzalez Orta, Alejandro; Kaniskan, H Ümit; Hu, Jianping; Jin, Jian; Sievers, Sonja; Waldmann, Herbert; Giera, Martin; Sundström, Michael; Berg, Louise; Huber, Kilian V M

A BRET biosensor for measuring uncompetitive engagement of PRMT5 complexes in cells.

一种用于测量细胞中 PRMT5 复合物非竞争性结合的 BRET 生物传感器。

Rothweiler Elisabeth M, Michaud Ani, Stefaniak Jakub, Singh Usha, Mikulsky Brynwood B, Vasta James D, Beck Michael T, Wilkinson Jennifer, Ward Jennifer A, Rogers Catherine M, Balıkçı Esra, Tranberg-Jensen Jeppe, Hansen Jesper S, Loppnau Peter, Whitty Adrian, Brennan Paul E, Tonge Peter J, Robers Matthew B, Huber Kilian V M

Drug repurposing in amyotrophic lateral sclerosis (ALS)

肌萎缩侧索硬化症(ALS)的药物再利用

Carroll, Emily; Scaber, Jakub; Huber, Kilian V M; Brennan, Paul E; Thompson, Alexander G; Turner, Martin R; Talbot, Kevin

Toward target 2035: EUbOPEN - a public-private partnership to enable & unlock biology in the open

迈向2035年目标:EUbOPEN——一项旨在促进和开放生物学的公私合作项目

Tredup, Claudia; Ackloo, Suzanne; Beck, Hartmut; Brown, Peter J; Bullock, Alex N; Ciulli, Alessio; Dikic, Ivan; Edfeldt, Kristina; Edwards, Aled M; Elkins, Jonathan M; Farin, Henner F; Fon, Edward A; Gstaiger, Matthias; Günther, Judith; Gustavsson, Anna-Lena; Häberle, Sandra; Isigkeit, Laura; Huber, Kilian V M; Kotschy, Andras; Krämer, Oliver; Leach, Andrew R; Marsden, Brian D; Matsui, Hisanori; Merk, Daniel; Montel, Florian; Mulder, Monique P C; Müller, Susanne; Owen, Dafydd R; Proschak, Ewgenij; Röhm, Sandra; Stolz, Alexandra; Sundström, Michael; von Delft, Frank; Willson, Timothy M; Arrowsmith, Cheryl H; Knapp, Stefan

Bisphosphonates Trigger Anti-Ageing Effects Across Multiple Cell Types and Protect Against Senescence

双膦酸盐在多种细胞类型中引发抗衰老作用并防止细胞衰老。

Lu, Jinsen; Rao, Srinivasa Rao; Knowles, Helen; Zhan, Haoqun; Gamez, Beatriz; Platt, Eleanor; Frost, Lucy R; Allen, Tiffany-Jayne; Marshall, Gayle; Huber, Kilian V M; Bauer, Ludwig G; Vendrell, Iolanda; Kessler, Benedikt; Horne, Anne; Reid, Ian R; Bountra, Chas; Kirkland, James L; Khosla, Sundeep; Hal Ebetino, F; Roldan, Emilio; Russell, R Graham G; Edwards, James R

Paralogue-Selective Degradation of the Lysine Acetyltransferase EP300

赖氨酸乙酰转移酶EP300的旁系同源选择性降解

Chen, Xuemin; Crawford, McKenna C; Xiong, Ying; Shaik, Anver Basha; Suazo, Kiall F; Bauer, Ludwig G; Penikalapati, Manini S; Williams, Joycelyn H; Huber, Kilian V M; Andressen, Thorkell; Swenson, Rolf E; Meier, Jordan L

Covalent Inhibitors of KEAP1 with Exquisite Selectivity.

具有极高选择性的KEAP1共价抑制剂

Fejes Imre, Markacz Piroska, Tatai Janos, Rudas Monika, Dunkel Petra, Gyuris Mario, Nyerges Miklos, Provost Nicolas, Duvivier Valérie, Delerive Philippe, Martiny Virginie, Bristiel Alexandra, Vidal Brice, Richardson William, Rothweiler Elisabeth M, Tranberg-Jensen Jeppe, Manning Charlotte E, Sweeney Melissa N, Chalk Rod, Huber Kilian V M, Bullock Alex N, Herner Andras, Seedorf Klaus, Vinson Cedric, Weber Csaba, Kotschy Andras

Cyclic peptides target the aromatic cage of a PHD-finger reader domain to modulate epigenetic protein function

环状肽靶向PHD指状结构域的芳香笼,从而调节表观遗传蛋白功能。

Coleman, Oliver D; Macdonald, Jessica; Thomson, Ben; Ward, Jennifer A; Stubbs, Christopher J; McAllister, Tom E; Clark, Shane; Amin, Siddique; Cao, Yimang; Abboud, Martine I; Zhang, Yijia; Sanganee, Hitesh; Huber, Kilian V M; Claridge, Tim D W; Kawamura, Akane

Fragment Screening Reveals Starting Points for Rational Design of Galactokinase 1 Inhibitors to Treat Classic Galactosemia

片段筛选揭示了合理设计半乳糖激酶 1 抑制剂治疗经典型半乳糖血症的起点。

Mackinnon, Sabrina R; Krojer, Tobias; Foster, William R; Diaz-Saez, Laura; Tang, Manshu; Huber, Kilian V M; von Delft, Frank; Lai, Kent; Brennan, Paul E; Arruda Bezerra, Gustavo; Yue, Wyatt W