Formation of Pmel17 amyloid is regulated by juxtamembrane metalloproteinase cleavage, and the resulting C-terminal fragment is a substrate for gamma-secretase.

Pmel17 淀粉样蛋白的形成受近膜金属蛋白酶切割的调控，产生的 C 端片段是 γ-分泌酶的底物