日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Structural basis for activation and conformational plasticity of the GluA4 AMPA receptor

GluA4 AMPA受体激活和构象可塑性的结构基础

Hale, W D; Wang, Haobo; Huganir, Richard L; Twomey, Edward C

Dysregulated GluA2-Y876 phosphorylation contributes to loss of synaptic upscaling in GRIP1 mutant mice with reduced sociability and increased repetitive behavior

GluA2-Y876磷酸化失调导致GRIP1突变小鼠突触上调功能丧失,并伴有社交能力下降和重复行为增加。

Han, Mei; Tan, Han L; Mejías, Rebeca; Chiu, Shu-Ling; Kim, Juhyun; Huganir, Richard L; Wang, Tao

The ionotropic AMPA receptor contributes to autoimmunity via altered regulatory T cell differentiation.

离子型 AMPA 受体通过改变调节性 T 细胞分化而导致自身免疫性疾病。

Mitchell-Flack Marisa, Higgins Makenzie, Zheng Ying, Tam Ada, Goldschmidt Hana, Nishio Hiroshi, Liu Bian, Cherry Christopher M, Patatanian Michael, Blosser Richard, Mun Sung Soo, Suru Aditya, Huganir Richard, Yu Hong, Pardoll Drew

DELTA: a method for brain-wide measurement of synaptic protein turnover reveals localized plasticity during learning.

DELTA:一种用于测量全脑突触蛋白周转率的方法,揭示了学习过程中的局部可塑性

Mohar Boaz, Michel Gabriela, Wang Yi-Zhi, Hernandez Veronica, Grimm Jonathan B, Park Jin-Yong, Patel Ronak, Clarke Morgan, Brown Timothy A, Bergmann Cornelius, Gebis Kamil K, Wilen Anika P, Liu Bian, Johnson Richard, Graves Austin, Tchumatchenko Tatjana, Savas Jeffrey N, Fornasiero Eugenio F, Huganir Richard L, Tillberg Paul W, Lavis Luke D, Svoboda Karel, Spruston Nelson

Structure of transmembrane AMPA receptor regulatory protein subunit γ2

跨膜AMPA受体调节蛋白亚基γ2的结构

Hale, W Dylan; Romero, Alejandra Montaño; Koylass, Nicholas; Warrick, Collin R; Qiu, Zhaozhu; Huganir, Richard L; Twomey, Edward C

Dissociation of SYNGAP1 enzymatic and structural roles: Intrinsic excitability and seizure susceptibility

SYNGAP1酶促作用和结构作用的分离:内在兴奋性和癫痫易感性

Brill, Julia; Clarke, Blaise; Hong, Ingie; Huganir, Richard L

Transcriptional signatures of hippocampal tau pathology in primary age-related tauopathy and Alzheimer's disease.

原发性年龄相关性 tau 蛋白病和阿尔茨海默病中海马 tau 蛋白病理的转录特征

Stein-O'Brien Genevieve L, Palaganas Ryan, Meyer Ernest M, Redding-Ochoa Javier, Pletnikova Olga, Guo Haidan, Bell William R, Troncoso Juan C, Huganir Richard L, Morris Meaghan

Loss of the proton-activated chloride channel in neurons impairs AMPA receptor endocytosis and LTD via endosomal hyper-acidification.

神经元中质子激活氯离子通道的缺失会通过内体过度酸化损害 AMPA 受体内吞作用和 LTD

Chen Kevin H, Yang Junhua, Liu Bian, Jiang Chaohua, Koylass Nicholas, Zhang Zhe, Sun Shuying, Huganir Richard, Qiu Zhaozhu

Dissociation of SYNGAP1 Enzymatic and Structural Roles: Intrinsic Excitability and Seizure Susceptibility

SYNGAP1酶促作用和结构作用的分离:内在兴奋性和癫痫易感性

Brill, Julia; Clarke, Blaise; Hong, Ingie; Huganir, Richard L

CRISPR-mediated transcriptional activation as a mutation-independent therapeutic strategy for SYNGAP1-related intellectual disability

CRISPR介导的转录激活作为一种不依赖于突变的SYNGAP1相关智力障碍治疗策略

Sichlinger, Laura; Reilly, Molly B; Arora, Sakshi; Zhang, Shuo; Marotta, Nicolas; Rodríguez-Acevedo, Kiara L; Hooks, Marisol; Czarnecki, Kyle S; Winter, Julia J; Waxman, Elisa A; Dungan, Lea V; Hong, Ingie; Araki, Yoichi; Johnson, Richard; Huganir, Richard L; Pavani, Giulia; French, Deborah L; Davidson, Beverly L; Prosser, Benjamin L; Heller, Elizabeth A