日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

MTA-cooperative PRMT5 inhibitors from cofactor-directed DNA-encoded library screens.

通过辅因子导向的DNA编码文库筛选得到的MTA协同PRMT5抑制剂

Andersson Jan, Cowland Sanne, Vestergaard Mikkel, Yang Yajing, Liu Siyuan, Fang Xie, Mukund Susmith, Ghimire-Rijal Sudipa, Carter Chris, Chung Grace, Jacso Tomas, Sarvary Ian, Hughes Paul E, Gouliaev Alex, Payton Marc, Belmontes Brian, Caenepeel Sean, Franch Thomas, Glad Sanne, Husemoen Birgitte, Nielsen Søren Jensby

From DNA-Encoded Library Screening to AM-9747: An MTA-Cooperative PRMT5 Inhibitor with Potent Oral In Vivo Efficacy.

从 DNA 编码文库筛选到 AM-9747:一种具有强效口服体内疗效的 MTA 协同 PRMT5 抑制剂

Sarvary Ian, Vestergaard Mikkel, Moretti Loris, Andersson Jan, Peiró Cadahía Jorge, Cowland Sanne, Flagstad Thomas, Franch Thomas, Gouliaev Alex, Husemoen Gitte, Jacso Tomas, Kronborg Titi, Kuropatnicka Aleksandra, Nadali Anna, Madsen Mads, Nielsen So Ren, Pii David, Ryborg So Ren, Soede Camillia, Allen Jennifer R, Bourbeau Matthew, Li Kexue, Liu Qingyian, Lo Mei-Chu, Madoux Franck, Mardirossian Narbe, Moriguchi Jodi, Ngo Rachel, Peng Chi-Chi, Pettus Liping, Tamayo Nuria, Wang Paul, Kapoor Rajiv, Belmontes Brian, Caenepeel Sean, Hughes Paul, Liu Siyuan, Slemmons Katherine K, Yang Yajing, Xie Fang, Ghimire-Rijal Sudipa, Mukund Susmith, Glad Sanne

Tropical peat composition may provide a negative feedback on fire occurrence and severity

热带泥炭的组成成分可能对火灾的发生和严重程度产生负反馈作用。

Crawford, Alastair J; Belcher, Claire M; New, Stacey; Gallego-Sala, Angela; Swindles, Graeme T; Page, Susan; Blyakharchuk, Tatiana A; Cadillo-Quiroz, Hinsby; Charman, Dan J; Gałka, Mariusz; Hughes, Paul D M; Lähteenoja, Outi; Mauquoy, Dmitri; Roland, Thomas P; Väliranta, Minna

SUMO-dependent transcriptional repression by Sox2 inhibits the proliferation of neural stem cells

Sox2介导的SUMO依赖性转录抑制抑制神经干细胞的增殖

Elisa Marelli ,Jaime Hughes ,Paul J Scotting

Image Phenotyping of Preterm-Born Children Using Hyperpolarized (129)Xe Lung Magnetic Resonance Imaging and Multiple-Breath Washout

利用超极化(129)Xe肺磁共振成像和多次呼吸冲洗法对早产儿进行图像表型分析

Chan, Ho-Fung; Smith, Laurie J; Biancardi, Alberto M; Bray, Jody; Marshall, Helen; Hughes, Paul J C; Collier, Guilhem J; Rao, Madhwesha; Norquay, Graham; Swift, Andrew J; Hart, Kylie; Cousins, Michael; Watkins, W John; Wild, Jim M; Kotecha, Sailesh

Correction: Combined inhibition of BCL-2 and MCL-1 overcomes BAX deficiency-mediated resistance of TP53-mutant acute myeloid leukemia to individual BH3 mimetics

更正:BCL-2 和 MCL-1 的联合抑制可克服 TP53 突变型急性髓系白血病对单一 BH3 模拟物的 BAX 缺陷介导的耐药性。

Carter, Bing Z; Mak, Po Yee; Tao, Wenjing; Ayoub, Edward; Ostermann, Lauren B; Huang, Xuelin; Loghavi, Sanam; Boettcher, Steffen; Nishida, Yuki; Ruvolo, Vivian; Hughes, Paul E; Morrow, Phuong K; Haferlach, Torsten; Kornblau, Steven; Muftuoglu, Muharrem; Andreeff, Michael

Inhibiting N-glycan processing increases the antibody binding affinity and effector function of human natural killer cells

抑制N-糖基化加工可提高抗体结合亲和力和人自然杀伤细胞的效应功能。

Maria Carolina Rodriguez Benavente ,Harrison B Hughes ,Paul G Kremer ,Ganesh P Subedi ,Adam W Barb

PhysVENeT: a physiologically-informed deep learning-based framework for the synthesis of 3D hyperpolarized gas MRI ventilation

PhysVENeT:一种基于生理信息的深度学习框架,用于合成三维超极化气体磁共振成像通气。

Astley, Joshua R; Biancardi, Alberto M; Marshall, Helen; Smith, Laurie J; Hughes, Paul J C; Collier, Guilhem J; Saunders, Laura C; Norquay, Graham; Tofan, Malina-Maria; Hatton, Matthew Q; Hughes, Rod; Wild, Jim M; Tahir, Bilal A

A Dual-Channel Deep Learning Approach for Lung Cavity Estimation From Hyperpolarized Gas and Proton MRI

基于超极化气体和质子磁共振成像的双通道深度学习肺腔估计方法

Astley, Joshua R; Biancardi, Alberto M; Marshall, Helen; Hughes, Paul J C; Collier, Guilhem J; Smith, Laurie J; Eaden, James A; Hughes, Rod; Wild, Jim M; Tahir, Bilal A

Implementable Deep Learning for Multi-sequence Proton MRI Lung Segmentation: A Multi-center, Multi-vendor, and Multi-disease Study

可实施的深度学习在多序列质子磁共振肺部分割中的应用:一项多中心、多厂商、多疾病研究

Astley, Joshua R; Biancardi, Alberto M; Hughes, Paul J C; Marshall, Helen; Collier, Guilhem J; Chan, Ho-Fung; Saunders, Laura C; Smith, Laurie J; Brook, Martin L; Thompson, Roger; Rowland-Jones, Sarah; Skeoch, Sarah; Bianchi, Stephen M; Hatton, Matthew Q; Rahman, Najib M; Ho, Ling-Pei; Brightling, Chris E; Wain, Louise V; Singapuri, Amisha; Evans, Rachael A; Moss, Alastair J; McCann, Gerry P; Neubauer, Stefan; Raman, Betty; Wild, Jim M; Tahir, Bilal A