日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Regime shift to extensive valley glaciations over High Mountain Asia during the Early-Middle Pleistocene

早-中更新世时期,高山亚洲地区冰川作用逐渐增强,形成广泛的山谷冰川。

Yan, Qing; Owen, Lewis A; Wei, Ting; Hughes, Philip D; Kong, Xiaohan; Jiang, Nanxuan; Zhang, Jinzhe; Zhang, Zhongshi; Wang, Huijun

Selective targeting of Plasmodium falciparum Hsp90 disrupts the 26S proteasome.

选择性靶向恶性疟原虫 Hsp90 可破坏 26S 蛋白酶体

Mansfield Christopher R, Quan Baiyi, Chirgwin Michael E, Eduful Benjamin, Hughes Philip F, Neveu Gaëlle, Sylvester Kayla, Ryan Daniel H, Kafsack Björn F C, Haystead Timothy A J, Leahy James W, Fitzgerald Michael C, Derbyshire Emily R

Transforming Growth Factor-β-Activated Kinase 1 (TAK1) Alleviates Inflammatory Joint Pain in Osteoarthritis and Gouty Arthritis Preclinical Models.

转化生长因子-β激活激酶1(TAK1)可缓解骨关节炎和痛风性关节炎临床前模型中的炎症性关节疼痛

Freeze Robert, Hughes Philip, Haystead Timothy, Scarneo Scott

Investigation of SARS-CoV-2 individual proteins reveals the in vitro and in vivo immunogenicity of membrane protein.

对 SARS-CoV-2 单个蛋白质的研究揭示了膜蛋白的体外和体内免疫原性

Haystead Timothy, Lee Eric, Cho Kirstin, Gullickson Gail, Hughes Philip, Krafsur Greta, Freeze Robert, Scarneo Scott

Delineation of the distinct inflammatory signaling roles of TAK1 and JAK1/3 in the CIA model of rheumatoid arthritis

在类风湿性关节炎的CIA模型中,阐明TAK1和JAK1/3在炎症信号传导中的不同作用

Freeze, Robert; Yang, Kelly W; Haystead, Timothy; Hughes, Philip; Scarneo, Scott

Combination of a novel heat shock protein 90-targeted photodynamic therapy with PD-1/PD-L1 blockade induces potent systemic antitumor efficacy and abscopal effect against breast cancers

新型靶向热休克蛋白90的光动力疗法与PD-1/PD-L1阻断疗法相结合,可诱导强效的全身抗肿瘤疗效和对乳腺癌的远隔效应。

Kaneko, Kensuke; Acharya, Chaitanya R; Nagata, Hiroshi; Yang, Xiao; Hartman, Zachary Conrad; Hobeika, Amy; Hughes, Philip F; Haystead, Timothy A J; Morse, Michael A; Lyerly, Herbert Kim; Osada, Takuya

HSP90-Specific nIR Probe Identifies Aggressive Prostate Cancers: Translation from Preclinical Models to a Human Phase I Study.

HSP90 特异性近红外探针可识别侵袭性前列腺癌:从临床前模型到人体 I 期研究的转化

Osada Takuya, Crosby Erika J, Kaneko Kensuke, Snyder Joshua C, Ginzel Joshua D, Acharya Chaitanya R, Yang Xiao-Yi, Polascik Thomas J, Spasojevic Ivan, Nelson Rendon C, Hobeika Amy, Hartman Zachary C, Neckers Leonard M, Rogatko Andre, Hughes Philip F, Huang Jiaoti, Morse Michael A, Haystead Timothy, Lyerly H Kim

Development and Efficacy of an Orally Bioavailable Selective TAK1 Inhibitor for the Treatment of Inflammatory Arthritis.

开发和评估口服生物利用度高的选择性TAK1抑制剂治疗炎症性关节炎的疗效

Scarneo Scott, Hughes Philip, Freeze Robert, Yang Kelly, Totzke Juliane, Haystead Timothy

Understanding the sources of errors in ex vivo Hsp90 molecular imaging for rapid-on-site breast cancer diagnosis

了解体外 Hsp90 分子成像在快速现场乳腺癌诊断中的误差来源

Wang, Roujia; Alvarez, Daniel A; Crouch, Brian T; Pilani, Aditi; Lam, Christopher; Zhu, Caigang; Hughes, Philip; Katz, David; Haystead, Timothy; Ramanujam, Nirmala

Targeting therapy-resistant prostate cancer via a direct inhibitor of the human heat shock transcription factor 1

利用人类热休克转录因子1的直接抑制剂靶向治疗耐药性前列腺癌

Dong, Bushu; Jaeger, Alex M; Hughes, Philip F; Loiselle, David R; Hauck, J Spencer; Fu, Yao; Haystead, Timothy A; Huang, Jiaoti; Thiele, Dennis J