日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Selective targeting of Plasmodium falciparum Hsp90 disrupts the 26S proteasome.

选择性靶向恶性疟原虫 Hsp90 可破坏 26S 蛋白酶体

Mansfield Christopher R, Quan Baiyi, Chirgwin Michael E, Eduful Benjamin, Hughes Philip F, Neveu Gaëlle, Sylvester Kayla, Ryan Daniel H, Kafsack Björn F C, Haystead Timothy A J, Leahy James W, Fitzgerald Michael C, Derbyshire Emily R

Combination of a novel heat shock protein 90-targeted photodynamic therapy with PD-1/PD-L1 blockade induces potent systemic antitumor efficacy and abscopal effect against breast cancers

新型靶向热休克蛋白90的光动力疗法与PD-1/PD-L1阻断疗法相结合,可诱导强效的全身抗肿瘤疗效和对乳腺癌的远隔效应。

Kaneko, Kensuke; Acharya, Chaitanya R; Nagata, Hiroshi; Yang, Xiao; Hartman, Zachary Conrad; Hobeika, Amy; Hughes, Philip F; Haystead, Timothy A J; Morse, Michael A; Lyerly, Herbert Kim; Osada, Takuya

HSP90-Specific nIR Probe Identifies Aggressive Prostate Cancers: Translation from Preclinical Models to a Human Phase I Study.

HSP90 特异性近红外探针可识别侵袭性前列腺癌:从临床前模型到人体 I 期研究的转化

Osada Takuya, Crosby Erika J, Kaneko Kensuke, Snyder Joshua C, Ginzel Joshua D, Acharya Chaitanya R, Yang Xiao-Yi, Polascik Thomas J, Spasojevic Ivan, Nelson Rendon C, Hobeika Amy, Hartman Zachary C, Neckers Leonard M, Rogatko Andre, Hughes Philip F, Huang Jiaoti, Morse Michael A, Haystead Timothy, Lyerly H Kim

Targeting therapy-resistant prostate cancer via a direct inhibitor of the human heat shock transcription factor 1

利用人类热休克转录因子1的直接抑制剂靶向治疗耐药性前列腺癌

Dong, Bushu; Jaeger, Alex M; Hughes, Philip F; Loiselle, David R; Hauck, J Spencer; Fu, Yao; Haystead, Timothy A; Huang, Jiaoti; Thiele, Dennis J

A highly selective inhibitor of interleukin-1 receptor-associated kinases 1/4 (IRAK-1/4) delineates the distinct signaling roles of IRAK-1/4 and the TAK1 kinase.

白细胞介素-1受体相关激酶1/4(IRAK-1/4)的高选择性抑制剂阐明了IRAK-1/4和TAK1激酶不同的信号传导作用

Scarneo Scott A, Hughes Philip F, Yang Kelly W, Carlson David A, Gurbani Deepak, Westover Kenneth D, Haystead Timothy A J

An inducible heat shock protein 70 small molecule inhibitor demonstrates anti-dengue virus activity, validating Hsp70 as a host antiviral target

一种可诱导型热休克蛋白70小分子抑制剂显示出抗登革病毒活性,证实了Hsp70是宿主抗病毒靶点。

Howe, Matthew K; Speer, Brittany L; Hughes, Philip F; Loiselle, David R; Vasudevan, Subhash; Haystead, Timothy A J

Identification of an allosteric small-molecule inhibitor selective for the inducible form of heat shock protein 70

鉴定出一种对诱导型热休克蛋白70具有选择性的变构小分子抑制剂

Howe, Matthew K; Bodoor, Khaldon; Carlson, David A; Hughes, Philip F; Alwarawrah, Yazan; Loiselle, David R; Jaeger, Alex M; Darr, David B; Jordan, Jamie L; Hunter, Lucas M; Molzberger, Eileen T; Gobillot, Theodore A; Thiele, Dennis J; Brodsky, Jeffrey L; Spector, Neil L; Haystead, Timothy A J

Optical and radioiodinated tethered Hsp90 inhibitors reveal selective internalization of ectopic Hsp90 in malignant breast tumor cells

光学和放射性碘标记的Hsp90抑制剂揭示了恶性乳腺肿瘤细胞中异位表达的Hsp90的选择性内化。

Barrott, Jared J; Hughes, Philip F; Osada, Takuya; Yang, Xiao-Yi; Hartman, Zachary C; Loiselle, David R; Spector, Neil L; Neckers, Len; Rajaram, Narasimhan; Hu, Fangyao; Ramanujam, Nimmi; Vaidyanathan, Ganesan; Zalutsky, Michael R; Lyerly, H Kim; Haystead, Timothy A