文献库，生知库 | 链接生命科学的每一步

Winer, Daniel A; Du, Huixun; Kim, JangKeun; Chang, Veronica; Burke, Marissa; Winer, Shawn; Costes, Sylvain V; Frippiat, Jean-Pol; Sams, Clarence; Paul, Amber M; Wu, Honglu; Ullrich, Oliver; Baatout, Sarah; Beheshti, Afshin; Mason, Christopher E; Choukér, Alexander; Crucian, Brian E

免疫/内分泌

发表日期：2026

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Efficacy and Safety of Efdamrofusp Alfa with Personalized Dosing Intervals in Neovascular Age-Related Macular Degeneration: A Phase II Trial

采用个性化给药间隔的 Efdamrofusp Alfa 治疗新生血管性年龄相关性黄斑变性的疗效和安全性：一项 II 期试验

期刊:Ophthalmology Science

影响因子:4.6

doi:10.1016/j.xops.2025.100913

Li, Tong; Yang, Shiqi; Liu, Qinghuai; Song, Yanping; Tong, Jianping; Wei, Wenbin; Chen, Weiqi; Dai, Hong; Wang, Wei; Wu, Miaoqin; Zhou, Guohong; Xiao, Xuan; Zhang, Jinglin; Zhu, Rongrong; Li, Haoyu; Wang, Yafang; Chen, Xiaoyu; Lu, Shujie; Du, Haiwei; Han-Zhang, Han; Hao, Jilong; Li, Chaopeng; Wen, Ying; Zhang, Jie; Sun, Junran; Jia, Huixun; Sun, Xiaodong

发表日期：2026

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Intravitreal Gene Therapy with LX102-C01 in Neovascular Age-Related Macular Degeneration: A Phase I Dose-Escalation Study of 12-Month Safety and Efficacy Outcomes

LX102-C01玻璃体内基因治疗新生血管性年龄相关性黄斑变性：一项为期12个月的I期剂量递增安全性和有效性研究

期刊:Ophthalmology Science

影响因子:4.6

doi:10.1016/j.xops.2025.100970

Sun, Junran; Shen, Mengxi; Chen, Jieqiong; Wu, Yidong; Zhou, Yanping; Feng, Jingyang; Cheng, Yuxuan; Jia, Huixun; Yang, Xiaolu; Gong, YuanYuan; Liu, Yang; Wang, Hong; Wang, Ruikang K; Rosenfeld, Philip J; Li, Tong; Wang, Fenghua; Sun, Xiaodong

基因治疗

发表日期：2026

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Clinical and Molecular Characteristics of Foveal Sparing Phenotype in Chinese Patients With Inherited Retinal Diseases

中国遗传性视网膜疾病患者黄斑保留表型的临床和分子特征

期刊:Translational Vision Science & Technology

影响因子:2.6

doi:10.1167/tvst.15.2.18

Wang, Zilin; Li, Tong; Chen, Jieqiong; Sun, Yiqing; Jia, Huixun; Sun, Junran; Sun, Xiaodong

发表日期：2026

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Advanced Bayesian kernel machine regression for large-scale exposome studies: Making the impossible possible

用于大规模暴露组研究的高级贝叶斯核机器回归：化不可能为可能

期刊:

影响因子:

doi:10.1016/j.xinn.2025.101248

Guo, Yi; Jia, Huixun; Peng, Ziwei; Xu, Xinming; Zhang, Zhicheng; Pan, Keyu; Zhou, Yuqin; Kan, Haidong; Wu, Zhenyu; Liu, Cong

发表日期：2026

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Climate warming may undermine sleep duration and quality in repeated-measure study of 23 million records

气候变暖可能损害睡眠时长和质量，一项对2300万条记录的重复测量研究表明了这一点。

期刊:Nature Communications

影响因子:15.7

doi:10.1038/s41467-025-57781-y

Li, Anni; Luo, Huihuan; Zhu, Yixiang; Zhang, Zheqi; Liu, Binbin; Kan, Haidong; Jia, Huixun; Wu, Zhenyu; Guo, Yutao; Chen, Renjie

发表日期：2025

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Enhancing clinical documentation with voice processing and large language models: a study on the LAOS system

利用语音处理和大型语言模型增强临床文档：LAOS系统研究

期刊:npj Digital Medicine

影响因子:15.1

doi:10.1038/s41746-025-02170-4

Xu, Yupeng; Jia, Huixun; Wang, Maolin; Feng, Jie; Xu, Xun; Wang, Haiyan; Chen, Jieqiong; Zheng, Zheng; Yang, Xiaoyan; Shen, Yue; Wang, Jian; Zhuang, Chenyi; Wei, Peng; Guo, Ruocheng; Zhao, Xiangyu; Fan, Junxiang; Sun, Xiaodong

发表日期：2025

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Molecular marker discovery and detection for blinding eye disease

致盲性眼病的分子标记发现与检测

期刊:Journal of Nanobiotechnology

影响因子:12.6

doi:10.1186/s12951-025-03627-0

Gao, Shunxiang; Guo, Dongling; Huang, Peirong; Yin, Ning; Jia, Huixun; Li, Shengjie; Sun, Xiaodong; Zhu, Xiangjia

发表日期：2025

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Amyloid-β-driven Alzheimer's disease reshapes the colonic immune system in mice

淀粉样蛋白β驱动的阿尔茨海默病会重塑小鼠的结肠免疫系统。

期刊:Cell Reports

影响因子:7.5

doi:10.1016/j.celrep.2025.116109

Priya Makhijani ，Taylor R Valentino ，Max Manwaring-Mueller ，Rohini Emani ，Wei-Chieh Mu ，Carlos Galicia Aguirre ，Christopher Ryan Tan ，Anand Rane ，Kenneth A Wilson ，Alexander Kifle ，Nan Chen ，Huixun Du ，Fei Wu ，Jenny Hong Yu Ng ，Benjamin D Ambrose ，Prasanna Vadhana Ashok Kumaar ，Saad Khan ，Shawn Winer ，Chao Wang ，Arthur Mortha ，David Furman ，Birgit Schilling ，Lisa M Ellerby ，Olga L Rojas ，Julie K Andersen ，Daniel A Winer

免疫/内分泌

发表日期：2025

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Substrate stiffness dictates unique doxorubicin-induced senescence-associated secretory phenotypes and transcriptomic signatures in human pulmonary fibroblasts.

基质硬度决定了人类肺成纤维细胞中独特的阿霉素诱导衰老相关分泌表型和转录组特征

期刊:Geroscience

影响因子:5.4

doi:10.1007/s11357-025-01507-x

Du Huixun, Rose Jacob P, Bons Joanna, Guo Li, Valentino Taylor R, Wu Fei, Burton Jordan B, Basisty Nathan, Manwaring-Mueller Max, Makhijani Priya, Chen Nan, Chang Veronica, Winer Shawn, Campisi Judith, Furman David, Nagy Andras, Schilling Birgit, Winer Daniel A

Astroimmunology: the effects of spaceflight and its associated stressors on the immune system

太空免疫学：太空飞行及其相关应激因素对免疫系统的影响

Efficacy and Safety of Efdamrofusp Alfa with Personalized Dosing Intervals in Neovascular Age-Related Macular Degeneration: A Phase II Trial

采用个性化给药间隔的 Efdamrofusp Alfa 治疗新生血管性年龄相关性黄斑变性的疗效和安全性：一项 II 期试验

Intravitreal Gene Therapy with LX102-C01 in Neovascular Age-Related Macular Degeneration: A Phase I Dose-Escalation Study of 12-Month Safety and Efficacy Outcomes

LX102-C01玻璃体内基因治疗新生血管性年龄相关性黄斑变性：一项为期12个月的I期剂量递增安全性和有效性研究

Clinical and Molecular Characteristics of Foveal Sparing Phenotype in Chinese Patients With Inherited Retinal Diseases

中国遗传性视网膜疾病患者黄斑保留表型的临床和分子特征

Advanced Bayesian kernel machine regression for large-scale exposome studies: Making the impossible possible

用于大规模暴露组研究的高级贝叶斯核机器回归：化不可能为可能

Climate warming may undermine sleep duration and quality in repeated-measure study of 23 million records

气候变暖可能损害睡眠时长和质量，一项对2300万条记录的重复测量研究表明了这一点。

Enhancing clinical documentation with voice processing and large language models: a study on the LAOS system

利用语音处理和大型语言模型增强临床文档：LAOS系统研究

Molecular marker discovery and detection for blinding eye disease

致盲性眼病的分子标记发现与检测

Amyloid-β-driven Alzheimer's disease reshapes the colonic immune system in mice

淀粉样蛋白β驱动的阿尔茨海默病会重塑小鼠的结肠免疫系统。

Substrate stiffness dictates unique doxorubicin-induced senescence-associated secretory phenotypes and transcriptomic signatures in human pulmonary fibroblasts.

基质硬度决定了人类肺成纤维细胞中独特的阿霉素诱导衰老相关分泌表型和转录组特征