日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Loss of Early Growth Response Protein 1 in the Liver Leads to Hepatic Lipid Accumulation Driven by an Imbalance Between Fatty Acid β-Oxidation and Oxidative Phosphorylation.

肝脏中早期生长反应蛋白 1 的缺失导致肝脏脂质积累,这是由于脂肪酸 β-氧化和氧化磷酸化之间的不平衡所致。

Verzijl Cristy R C, Struik Dicky, Gerding Albert, Eilers Roos E, Thomas Rachel E, Koster Mirjam, Langelaar-Makkinje Miriam, Smit Marieke, Huijkman Nicolette, Havinga Rick, Kloosterhuis Niels, Bloks Vincent W, Wolters Justina C, de Boer Jan Freark, van de Sluis Bart, Bakker Barbara M, Jonker Johan W

SMC Abca1 and Abcg1 Deficiency Enhances Urinary Bladder Distension but Not Atherosclerosis

SMC Abca1 和 Abcg1 缺乏会加剧膀胱扩张,但不会导致动脉粥样硬化。

Halmos, Benedek; La Rose, Anouk M; Methorst, Daisey; Groenen, Anouk G; Nakládal, Dalibor; Bazioti, Venetia; Koster, Mirjam H; Kloosterhuis, Niels J; Buiten, Azuwerus van; Schouten, Elisabeth M; Huijkman, Nicolette C A; Langelaar-Makkinje, Miriam; Bongiovanni, Laura; De Neck, Simon M; de Bruin, Alain; Buikema, Hendrik; Deelman, Leo E; van den Heuvel, Marius C; Kuipers, Folkert; de Jong, Igle Jan; Sluimer, Judith C; Jørgensen, Helle F; Henning, Robert H; Westerterp, Marit

Loss of hepatic SMLR1 causes hepatosteatosis and protects against atherosclerosis due to decreased hepatic VLDL secretion

肝脏SMLR1的缺失会导致肝脂肪变性,但由于肝脏VLDL分泌减少,因此可以预防动脉粥样硬化。

van Zwol, Willemien; Rimbert, Antoine; Wolters, Justina C; Smit, Marieke; Bloks, Vincent W; Kloosterhuis, Niels J; Huijkman, Nicolette C A; Koster, Mirjam H; Tharehalli, Umesh; de Neck, Simon M; Bournez, Colin; Fuh, Marceline M; Kuipers, Jeroen; Rajan, Sujith; de Bruin, Alain; Ginsberg, Henry N; van Westen, Gerard J P; Hussain, M Mahmood; Scheja, Ludger; Heeren, Joerg; Zimmerman, Philip; van de Sluis, Bart; Kuivenhoven, Jan Albert

Personalised modelling of clinical heterogeneity between medium-chain acyl-CoA dehydrogenase patients

中链酰基辅酶 A 脱氢酶患者临床异质性的个性化建模

Christoff Odendaal #, Emmalie A Jager #, Anne-Claire M F Martines, Marcel A Vieira-Lara, Nicolette C A Huijkman, Ligia A Kiyuna, Albert Gerding, Justina C Wolters, Rebecca Heiner-Fokkema, Karen van Eunen, Terry G J Derks, Barbara M Bakker

Selective Hepatic Cbs Knockout Aggravates Liver Damage, Endothelial Dysfunction and ROS Stress in Mice Fed a Western Diet

选择性肝脏 Cbs 敲除加重西方饮食喂养小鼠的肝损伤、内皮功能障碍和 ROS 应激

Sebastiaan Lambooy, Andries Heida, Christian Joschko, Dalibor Nakladal, Azuwerus van Buiten, Niels Kloosterhuis, Nicolette Huijkman, Albert Gerding, Bart van de Sluis, Robert Henning, Leo Deelman

Homozygous whole body Cbs knockout in adult mice features minimal pathology during ageing despite severe homocysteinemia

成年小鼠全身纯合 Cbs 敲除后,尽管患有严重的同型半胱氨酸血症,但在衰老过程中病理变化很小

D Nakladal, S P H Lambooy, S Mišúth, D Čepcová, C P Joschko, A van Buiten, M Goris, F Hoogstra-Berends, N J Kloosterhuis, N Huijkman, B van de Sluis, G F Diercks, J H Buikema, R H Henning, L E Deelman

Butyrate oxidation attenuates the butyrate-induced improvement of insulin sensitivity in myotubes

丁酸氧化减弱了丁酸诱导的肌管胰岛素敏感性的改善

Melany Rios-Morales, Marcel A Vieira-Lara, Esther Homan, Miriam Langelaar-Makkinje, Albert Gerding, Zhuang Li, Nicolette Huijkman, Patrick C N Rensen, Justina C Wolters, Dirk-Jan Reijngoud, Barbara M Bakker

Mice with a deficiency in Peroxisomal Membrane Protein 4 (PXMP4) display mild changes in hepatic lipid metabolism

过氧化物酶体膜蛋白 4 (PXMP4) 缺乏的小鼠肝脏脂质代谢出现轻微变化

Maaike Blankestijn, Vincent W Bloks, Dicky Struik, Nicolette Huijkman, Niels Kloosterhuis, Justina C Wolters, Ronald J A Wanders, Frédéric M Vaz, Markus Islinger, Folkert Kuipers, Bart van de Sluis, Albert K Groen, Henkjan J Verkade, Johan W Jonker

Modeling Phenotypic Heterogeneity of Glycogen Storage Disease Type 1a Liver Disease in Mice by Somatic CRISPR/CRISPR-associated protein 9-Mediated Gene Editing

利用体细胞 CRISPR/CRISPR 相关蛋白 9 介导的基因编辑技术构建小鼠 1a 型糖原贮积症肝病表型异质性模型

Rutten, Martijn G S; Derks, Terry G J; Huijkman, Nicolette C A; Bos, Trijnie; Kloosterhuis, Niels J; van de Kolk, Kees C W A; Wolters, Justina C; Koster, Mirjam H; Bongiovanni, Laura; Thomas, Rachel E; de Bruin, Alain; van de Sluis, Bart; Oosterveer, Maaike H

Taking One Step Back in Familial Hypercholesterolemia: STAP1 Does Not Alter Plasma LDL (Low-Density Lipoprotein) Cholesterol in Mice and Humans

家族性高胆固醇血症的回顾:STAP1 不会改变小鼠和人类血浆中的 LDL(低密度脂蛋白)胆固醇

Natalia Loaiza #, Merel L Hartgers #, Laurens F Reeskamp, Jan-Willem Balder, Antoine Rimbert, Venetia Bazioti, Justina C Wolters, Maaike Winkelmeijer, Hans P G Jansen, Geesje M Dallinga-Thie, Andrea Volta, Nicolette Huijkman, Marieke Smit, Niels Kloosterhuis, Mirjam Koster, Arthur F Svendsen, Bart v