日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Additive Effects of Dorzagliatin and Glucagon-Like Peptide 1 Receptor Agonism in a Novel Mouse Model of GCK-MODY and in Obese db/db Mice.

多扎格列汀和胰高血糖素样肽 1 受体激动剂在 GCK-MODY 新型小鼠模型和肥胖 db/db 小鼠中的叠加效应。

Salazar Shadai, Delgadillo-Silva Luis Fernando, Carapeto Priscila, Kenfaoui Mohamed Mourad, Dakessian Karen, Melhem Rana, Provencher-Girard Audrey, Ostinelli Giada, Turgeon Julie, Kaci Imane, Migneault Francis, Huising Mark O, Hébert Marie-Josée, Chaker-Margot Malik, Rutter Guy A

β Cell Gαs signaling is critical for physiological and pharmacological enhancement of insulin secretion

β细胞Gαs信号传导对于生理和药理学上增强胰岛素分泌至关重要。

Capozzi, Megan E; Bouslov, David; Sargsyan, Ashot; Chan, Michelle Y; Chen, Alex; Gray, Sarah M; Viloria, Katrina; Bareja, Akshay; Douros, Jonathan D; Lewandowski, Sophie L; Tong, Jason Cl; Hasib, Annie; Cuozzo, Federica; Ross, Elizabeth C; Foster, Matthew W; Weinstein, Lee S; Hussain, Mehboob A; Merrins, Matthew J; Willard, Francis S; Huising, Mark O; Sloop, Kyle W; Hodson, David J; D'Alessio, David A; Campbell, Jonathan E

Heterogeneity in the coordination of delta cells with beta cells is driven by both paracrine signals and low-density Cx36 gap junctions

δ细胞与β细胞协调性的异质性是由旁分泌信号和低密度Cx36间隙连接共同驱动的。

Pourhosseinzadeh, Mohammad S; Huang, Jessica L; Shin, Donghan; Hart, Ryan G; Framroze, Luhaiza Y; Guillen, Jaresley V; Sanchez, Joel; Tirado, Ramir V; Unanwa, Kelechi; Huising, Mark O

Free fatty acid receptor 4 agonists stimulate insulin secretion via different mechanisms in mouse versus human islets

游离脂肪酸受体4激动剂通过不同的机制刺激小鼠和人胰岛的胰岛素分泌。

Reininger, Laura; Rehman, Muhammad; Bouabcha, Amélia; Ferragne, Sarah; Tremblay, Caroline; Ethier, Mélanie; Kimple, Michelle E; Ghislain, Julien; Huising, Mark O; Poitout, Vincent

Somatostatin Receptors Shape Insulin and Glucagon Output within the Pancreatic Islet through Direct and Paracrine Effects

生长抑素受体通过直接和旁分泌作用调节胰岛内胰岛素和胰高血糖素的输出。

Hart, Ryan G; Lee, Jordan J; Zhai, Karen; Lee, Sharlene; Chauhan, Rashita; Hosseini, Aidean; Nguyen, Austin D; Huising, Mark O

Sex-dependent additive effects of dorzagliatin and incretin on insulin secretion in a novel mouse model of GCK-MODY.

在新型 GCK-MODY 小鼠模型中,多扎格列汀和肠促胰岛素对胰岛素分泌的性别依赖性叠加效应

Salazar Shadai, Delgadillo-Silva Luis Fernando, Carapeto Priscila, Dakessian Karen, Melhem Rana, Provencher-Girard Audrey, Ostinelli Giada, Turgeon Julie, Kaci Imane, Migneault Francis, Huising Mark O, Hébert Marie-Josée, Rutter Guy A

An Intraislet Paracrine Signaling Pathway That Enables Glucagon to Stimulate Pancreatic β-Cells

胰岛内旁分泌信号通路使胰高血糖素能够刺激胰岛β细胞

Caicedo, Alejandro; Huising, Mark O; Wess, Jürgen

Editorial: The pancreatic islet - a multifaceted hub of inter-cellular communication

社论:胰岛——细胞间通讯的多功能枢纽

Zhang, Quan; Huising, Mark O; Da Silva Xavier, Gabriela; Hauge-Evans, Astrid C

Chromatin accessibility differences between alpha, beta, and delta cells identifies common and cell type-specific enhancers

α、β 和 δ 细胞之间染色质可及性的差异揭示了共同的和细胞类型特异性的增强子

Mawla, Alex M; van der Meulen, Talitha; Huising, Mark O

IAPP-induced beta cell stress recapitulates the islet transcriptome in type 2 diabetes

IAPP诱导的β细胞应激可重现2型糖尿病中的胰岛转录组

Blencowe, Montgomery; Furterer, Allison; Wang, Qing; Gao, Fuying; Rosenberger, Madeline; Pei, Lina; Nomoto, Hiroshi; Mawla, Alex M; Huising, Mark O; Coppola, Giovanni; Yang, Xia; Butler, Peter C; Gurlo, Tatyana