Hukema相关文献与解析，生知库 | 链接生命科学的每一步

Hormonal adaptations to weight loss: Responses to an oral glucose load 4 weeks after obesity surgery and low-energy diet

体重减轻后的激素适应：肥胖手术和低能量饮食后4周口服葡萄糖负荷试验的反应

Fanni, Giovanni; Hukema, Fleur; Hetty, Susanne; Mathioudaki, Argyri; Sundbom, Magnus; Risérus, Ulf; Kullberg, Joel; Pereira, Maria J; Ahlström, Håkan; Eriksson, Jan W

代谢

Effects of cafeteria diet and caloric restriction on pituitary hormones and metabolic phenotype in male Wistar rats

高热量饮食和热量限制对雄性Wistar大鼠垂体激素和代谢表型的影响

期刊:Endocrine

影响因子:2.9

doi:10.1007/s12020-025-04448-9

Kagios, Christakis; Hetty, Susanne; Hukema, Fleur; Fanni, Giovanni; Roman, Erika; Eriksson, Jan W

Short antisense oligonucleotides alleviate the pleiotropic toxicity of RNA harboring expanded CGG repeats

短反义寡核苷酸可减轻含有扩增 CGG 重复序列的 RNA 的多效性毒性

期刊:Nature Communications

影响因子:14.7

doi:10.1038/s41467-021-21021-w

Magdalena Derbis, Emre Kul, Daria Niewiadomska, Michał Sekrecki, Agnieszka Piasecka, Katarzyna Taylor, Renate K Hukema, Oliver Stork, Krzysztof Sobczak

Neuropathology of FMR1-premutation carriers presenting with dementia and neuropsychiatric symptoms

FMR1基因前突变携带者出现痴呆和神经精神症状的神经病理学研究

期刊:Brain Communications

影响因子:4.5

doi:10.1093/braincomms/fcab007

Dijkstra, Anke A; Haify, Saif N; Verwey, Niek A; Prins, Niels D; van der Toorn, Esmay C; Rozemuller, Annemieke J M; Bugiani, Marianna; den Dunnen, Wilfred F A; Todd, Peter K; Charlet-Berguerand, Nicolas; Willemsen, Rob; Hukema, Renate K; Hoozemans, Jeroen J M

发表日期：2021

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Inducible expression of human C9ORF72 36x G(4)C(2) hexanucleotide repeats is sufficient to cause RAN translation and rapid muscular atrophy in mice

人源C9ORF72 36x G(4)C(2)六核苷酸重复序列的诱导表达足以引起小鼠RAN翻译和快速肌肉萎缩。

期刊:Disease Models & Mechanisms

影响因子:3.3

doi:10.1242/dmm.044842

Riemslagh, F W; van der Toorn, E C; Verhagen, R F M; Maas, A; Bosman, L W J; Hukema, R K; Willemsen, R

RAN

发表日期：2021

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Small molecule 1a reduces FMRpolyG-mediated toxicity in in vitro and in vivo models for FMR1 premutation.

小分子 1a 可降低 FMRpolyG 介导的 FMR1 前突变体外和体内模型的毒性

期刊:Human Molecular Genetics

影响因子:3.2

doi:10.1093/hmg/ddab143

Haify Saif N, Buijsen Ronald A M, Verwegen Lucas, Severijnen Lies-Anne W F M, de Boer Helen, Boumeester Valerie, Monshouwer Roos, Yang Wang-Yong, Cameron Michael D, Willemsen Rob, Disney Matthew D, Hukema Renate K

毒理研究

发表日期：2021

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Lack of a Clear Behavioral Phenotype in an Inducible FXTAS Mouse Model Despite the Presence of Neuronal FMRpolyG-Positive Aggregates

尽管存在神经元 FMRpolyG 阳性聚集体，但可诱导的 FXTAS 小鼠模型中缺乏明确的行为表型

期刊:Frontiers in Molecular Biosciences

影响因子:3.9

doi:10.3389/fmolb.2020.599101

Saif N Haify, Ruchira S D Mankoe, Valerie Boumeester, Esmay C van der Toorn, Rob F M Verhagen, Rob Willemsen, Renate K Hukema, Laurens W J Bosman

Astroglial-targeted expression of the fragile X CGG repeat premutation in mice yields RAN translation, motor deficits and possible evidence for cell-to-cell propagation of FXTAS pathology

小鼠中脆性 X CGG 重复前突变的星形胶质细胞靶向表达产生 RAN 翻译、运动障碍以及 FXTAS 病理细胞间传播的可能证据

期刊:Acta Neuropathologica Communications

影响因子:6.2

doi:10.1186/s40478-019-0677-7

H Jürgen Wenzel, Karl D Murray, Saif N Haify, Michael R Hunsaker, Jared J Schwartzer, Kyoungmi Kim, Albert R La Spada, Bryce L Sopher, Paul J Hagerman, Christopher Raske, Lies-Anne W F M Severijnen, Rob Willemsen, Renate K Hukema, Robert F Berman

Reduction of Fmr1 mRNA Levels Rescues Pathological Features in Cortical Neurons in a Model of FXTAS

在FXTAS模型中，降低Fmr1 mRNA水平可挽救皮层神经元的病理特征。

期刊:Molecular Therapy-Nucleic Acids

影响因子:6.1

doi:10.1016/j.omtn.2019.09.018

Drozd, Malgorzata; Delhaye, Sébastien; Maurin, Thomas; Castagnola, Sara; Grossi, Mauro; Brau, Frédéric; Jarjat, Marielle; Willemsen, Rob; Capovilla, Maria; Hukema, Renate K; Lalli, Enzo; Bardoni, Barbara

神经科学

发表日期：2019

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Modelling fragile X-associated neuropsychiatric disorders in young inducible 90CGG premutation mice

在年轻的可诱导90CGG前突变小鼠中模拟脆性X染色体相关神经精神疾病

Hormonal adaptations to weight loss: Responses to an oral glucose load 4 weeks after obesity surgery and low-energy diet

体重减轻后的激素适应：肥胖手术和低能量饮食后4周口服葡萄糖负荷试验的反应

Effects of cafeteria diet and caloric restriction on pituitary hormones and metabolic phenotype in male Wistar rats

高热量饮食和热量限制对雄性Wistar大鼠垂体激素和代谢表型的影响

Short antisense oligonucleotides alleviate the pleiotropic toxicity of RNA harboring expanded CGG repeats

短反义寡核苷酸可减轻含有扩增 CGG 重复序列的 RNA 的多效性毒性

Neuropathology of FMR1-premutation carriers presenting with dementia and neuropsychiatric symptoms

FMR1基因前突变携带者出现痴呆和神经精神症状的神经病理学研究

Inducible expression of human C9ORF72 36x G(4)C(2) hexanucleotide repeats is sufficient to cause RAN translation and rapid muscular atrophy in mice

人源C9ORF72 36x G(4)C(2)六核苷酸重复序列的诱导表达足以引起小鼠RAN翻译和快速肌肉萎缩。

Small molecule 1a reduces FMRpolyG-mediated toxicity in in vitro and in vivo models for FMR1 premutation.

小分子 1a 可降低 FMRpolyG 介导的 FMR1 前突变体外和体内模型的毒性

Lack of a Clear Behavioral Phenotype in an Inducible FXTAS Mouse Model Despite the Presence of Neuronal FMRpolyG-Positive Aggregates

尽管存在神经元 FMRpolyG 阳性聚集体，但可诱导的 FXTAS 小鼠模型中缺乏明确的行为表型

Astroglial-targeted expression of the fragile X CGG repeat premutation in mice yields RAN translation, motor deficits and possible evidence for cell-to-cell propagation of FXTAS pathology

小鼠中脆性 X CGG 重复前突变的星形胶质细胞靶向表达产生 RAN 翻译、运动障碍以及 FXTAS 病理细胞间传播的可能证据

Reduction of Fmr1 mRNA Levels Rescues Pathological Features in Cortical Neurons in a Model of FXTAS

在FXTAS模型中，降低Fmr1 mRNA水平可挽救皮层神经元的病理特征。