日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Assessment of clinical and neuroimaging efficacy of treatment targeting tau pathology in mild cognitive impairment and mild to moderate Alzheimer's disease with hydromethylthionine mesylate using external control data

利用外部对照数据评估以甲磺酸氢甲基硫氨酸为靶点治疗轻度认知障碍和轻度至中度阿尔茨海默病中tau蛋白病理的临床和神经影像学疗效

Schelter, Bjoern O; Shiells, Helen; Lo, Serena; Nazlee, Nafeesa; Evans, Emily; Bentham, Peter; Gauthier, Serge; Zetterberg, Henrik; Wilcock, Gordon K; Froelich, Lutz; Burns, Alistair; MacSweeney, Emer; Ballard, Clive; Yu, Jin-Tai; Choon, Tay Siew; Asvatourian, Vahe; Muehlemann, Natalia; Priel, Jan; Kook, Karin; Sullivan, Tenecia; Downie, Diane; Miller, Sonya; Pringle, Carol; Storey, John M D; Baddeley, Tom; Harrington, Charles R; Staff, Roger; Sandu, Anca-Larisa; Hull, Claire; Stefanacci, Richard; Wischik, Claude M

Clinical, imaging and blood biomarker outcomes in a Phase 3 clinical trial of tau aggregation inhibitor hydromethylthionine mesylate in mild cognitive impairment and mild to moderate dementia due to Alzheimer's disease

一项针对轻度认知障碍和阿尔茨海默病引起的轻度至中度痴呆的tau蛋白聚集抑制剂甲磺酸氢甲基硫氨酸的3期临床试验的临床、影像学和血液生物标志物结果

Wischik, Claude M; Stefanacci, Richard; Bentham, Peter; Gauthier, Serge; Zetterberg, Henrik; Wilcock, Gordon K; Froelich, Lutz; Burns, Alistair; MacSweeney, Emer; Ballard, Clive; Yu, Jin-Tai; Choon, Tay Siew; Asvatourian, Vahe; Muehlemann, Natalia; Priel, Jan; Kook, Karin; Sullivan, Tenecia; Downie, Diane; Miller, Sonya; Pringle, Carol; Storey, John M D; Baddeley, Tom; Harrington, Charles R; Penny, Lewis K; Arastoo, Mohammad; Staff, Roger; Sandu, Anca-Larisa; Shiells, Helen; Lo, Serena; Nazlee, Nafeesa; Evans, Emily; Hull, Claire; Schelter, Bjoern O

Hydromethylthionine sustains truncated tau-dependent inflammation-lowering effects in mouse brain.

氢甲基硫氨酸在小鼠脑中维持截短的 tau 依赖性炎症降低作用

Santos Renato X, Lee Sophie H, Lofthouse Richard, Melis Valeria, Robinson Lianne, Leith Michael, Dreesen Eline, Armstrong Paul, Vorley Thomas, Goatman Elizabeth A, Hull Claire, Riedel Gernot, Wischik Claude M, Harrington Charles R

Exploring the Anti-Hypoxaemia Effect of Hydromethylthionine: A Prospective Study of Phase 3 Clinical Trial Participants

探索氢甲基硫氨酸的抗低氧血症作用:一项针对3期临床试验参与者的前瞻性研究

Arastoo, Mohammad; Mazanetz, Michael P; Miller, Sonya; Shiells, Helen; Hull, Claire; Robinson, Keith; Storey, John M D; Harrington, Charles R; Wischik, Claude M

Apolipoprotein E loss of function: Influence on murine brain markers of physiology and pathology

载脂蛋白E功能丧失:对小鼠脑生理和病理标志物的影响

Buchanan, Heather; Hull, Claire; Cacho Barraza, Maria; Delibegovic, Mirela; Platt, Bettina

Co-production of 11α-hydroxyprogesterone and ethanol using recombinant yeast expressing fungal steroid hydroxylases

利用表达真菌甾醇羟化酶的重组酵母共生产11α-羟孕酮和乙醇

Hull, Claire M; Warrilow, Andrew G S; Rolley, Nicola J; Price, Claire L; Donnison, Iain S; Kelly, Diane E; Kelly, Steven L

Co-production of bioethanol and probiotic yeast biomass from agricultural feedstock: application of the rural biorefinery concept

利用农业原料联产生物乙醇和益生菌酵母生物质:农村生物炼制概念的应用

Hull, Claire M; Loveridge, E Joel; Donnison, Iain S; Kelly, Diane E; Kelly, Steven L

Combined exome and whole-genome sequencing identifies mutations in ARMC4 as a cause of primary ciliary dyskinesia with defects in the outer dynein arm

外显子组和全基因组测序联合鉴定出 ARMC4 突变是原发性纤毛运动障碍的病因,该病因伴有外动力蛋白臂缺陷

Alexandros Onoufriadis, Amelia Shoemark, Mustafa M Munye, Chela T James, Miriam Schmidts, Mitali Patel, Elisabeth M Rosser, Chiara Bacchelli, Philip L Beales, Peter J Scambler, Stephen L Hart, Jeannette E Danke-Roelse, John J Sloper, Sarah Hull, Claire Hogg, Richard D Emes, Gerard Pals, Anthony T Mo