日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

IRE1α Is a Therapeutic Target for Cystic Fibrosis Airway Inflammation

IRE1α 是囊性纤维化气道炎症的治疗靶点

Emily A Hull-Ryde, John T Minges, Mary E B Martino, Takafumi Kato, Jacqueline L Norris-Drouin, Carla M P Ribeiro

XBP1S Regulates MUC5B in a Promoter Variant-Dependent Pathway in Idiopathic Pulmonary Fibrosis Airway Epithelia

XBP1S通过启动子变异依赖性通路调控特发性肺纤维化气道上皮细胞中的MUC5B。

Chen, Gang; Ribeiro, Carla M P; Sun, Ling; Okuda, Kenichi; Kato, Takafumi; Gilmore, Rodney C; Martino, Mary B; Dang, Hong; Abzhanova, Aiman; Lin, Jennifer M; Hull-Ryde, Emily A; Volmer, Allison S; Randell, Scott H; Livraghi-Butrico, Alessandra; Deng, Yingfeng; Scherer, Philipp E; Stripp, Barry R; O'Neal, Wanda K; Boucher, Richard C

Identification of small molecule inhibitors that block the Toxoplasma gondii rhoptry kinase ROP18

鉴定能阻断弓形虫顶端复合体激酶 ROP18 的小分子抑制剂

Simpson, Catherine; Jones, Nathaniel G; Hull-Ryde, Emily A; Kireev, Dmitri; Stashko, Michael; Tang, Keliang; Janetka, Jim; Wildman, Scott A; Zuercher, William J; Schapira, Matthieu; Hui, Raymond; Janzen, William; Sibley, L David

High-throughput screening identifies small molecules that enhance the pharmacological effects of oligonucleotides

高通量筛选可鉴定出能增强寡核苷酸药理作用的小分子。

Yang, B; Ming, X; Cao, C; Laing, B; Yuan, A; Porter, M A; Hull-Ryde, E A; Maddry, J; Suto, M; Janzen, W P; Juliano, R L

Development of a High-Throughput Screening Assay to Identify Inhibitors of the Lipid Kinase PIP5K1C

开发高通量筛选检测方法以鉴定脂质激酶 PIP5K1C 的抑制剂

Brittany D Wright, Catherine Simpson, Michael Stashko, Dmitri Kireev, Emily A Hull-Ryde, Mark J Zylka, William P Janzen

Filtration improves the performance of a high-throughput screen for anti-mycobacterial compounds

过滤可提高抗分枝杆菌化合物高通量筛选的性能

Nancy Cheng, Melissa A Porter, Lloyd W Frick, Yvonne Nguyen, Jennifer D Hayden, Ellen F Young, Miriam S Braunstein, Emily A Hull-Ryde, William P Janzen

Development of a Novel Screening Strategy Designed to Discover a New Class of HIV Drugs

开发一种新型筛选策略,旨在发现一类新型 HIV 药物

Nancy Cheng, Sook-Kyung Lee, P Scott Donover, Mel Reichman, Celia A Schiffer, Emily A Hull-Ryde, Ronald Swanstrom, William P Janzen

UNC569, a novel small-molecule mer inhibitor with efficacy against acute lymphoblastic leukemia in vitro and in vivo

UNC569,一种新型小分子抑制剂,在体内外均具有抗急性淋巴细胞白血病的疗效

Sandra Christoph, Deborah Deryckere, Jennifer Schlegel, J Kimble Frazer, Lance A Batchelor, Alesia Y Trakhimets, Susan Sather, Debra M Hunter, Christopher T Cummings, Jing Liu, Chao Yang, Dmitri Kireev, Catherine Simpson, Jacqueline Norris-Drouin, Emily A Hull-Ryde, William P Janzen, Gary L Johnson,

A sensitive assay using a native protein substrate for screening HIV-1 maturation inhibitors targeting the protease cleavage site between the matrix and capsid

使用天然蛋白质底物进行敏感检测,以筛选基质和衣壳之间的蛋白酶裂解位点为目标的 HIV-1 成熟抑制剂

Sook-Kyung Lee, Nancy Cheng, Emily Hull-Ryde, Marc Potempa, Celia A Schiffer, William Janzen, Ronald Swanstrom

Orally active adenosine A(1) receptor agonists with antinociceptive effects in mice

口服腺苷A(1)受体激动剂对小鼠具有抗伤害作用

Ilia Korboukh, Emily A Hull-Ryde, Joseph E Rittiner, Amarjit S Randhawa, Jennifer Coleman, Brendan J Fitzpatrick, Vincent Setola, William P Janzen, Stephen V Frye, Mark J Zylka, Jian Jin